Photochemical fate of pharmaceuticals in the environment: Naproxen, diclofenac, clofibric acid, and ibuprofen

Packer, Jennifer L.; Werner, Jeffrey J.; Latch, Douglas E.; McNeill, Kristopher; Arnold, William A.

doi:10.1007/s00027-003-0671-8

Cited by 394 publications

(227 citation statements)

References 46 publications

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“…The degradation of DCF has been investigated both under direct photolysis [26][27][28][29] and by TiO 2 photocatalysis. [13,[30][31][32][33][34] Existing studies describing photolysis either in the laboratory or in the natural environment using sunlight have reported direct photolysis as the main depletion mechanism for DCF.…”

Section: Introductionmentioning

confidence: 99%

Photolysis and TiO2-catalysed degradation of diclofenac in surface and drinking water using circulating batch photoreactors

Kanakaraju¹,

Cherie²,

Motti³

et al. 2014

Environ. Chem.

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Environmental context. Diclofenac, a common non-steroidal anti-inflammatory drug, is not completely removed from surface and drinking water by conventional treatment methods. Consequently, this drug is present in the aquatic environment and has been subsequently linked to toxic effects on organisms. We show that photolysis and TiO 2 -catalysed degradation in circulating batch reactors efficiently results in diclofenac removal under a variety of conditions. These photochemical methods thus may lead to more effective water treatment processes.Abstract. The occurrence of diclofenac (DCF) as an emerging pollutant in surface waters and drinking water has been attributed to elevated global consumption and the inability of sewage treatment plants to remove DCF. In this study, DCF spiked drinking water and river water was subjected to photolysis and TiO 2 photocatalytic treatments in a circulating laboratory-scale (immersion-well) and a demonstration-scale loop reactor (Laboclean). The operational parameters for the immersion-well reactor were optimised as follows: TiO 2 P25 loading, 0.1 g L À1 ; natural pH, 6.2; initial concentration, 30 mg L À1 ; water type, distilled water. Complete DCF removal was realised within 15 min under the optimised conditions using the immersion-well reactor. Sunlight-mediated photochemical degradation required a prolonged exposure period of up to 360 min for complete DCF removal. DCF in distilled and drinking water was efficiently degraded in the larger Laboclean reactor. Differences were, however, observed based on their pseudo-first-order rate constants, which implies that the water matrix has an effect on the degradation rate. Six major photoproducts, 2-(8-chloro-9H-carbazol-1-yl)acetic acid, 2-(8-hydroxy-9H-carbazol-1-yl)acetic acid, 2,6-dichloro-N-o-tolylbenzenamine, 2-(phenylamino)benzaldehyde, 1-chloromethyl-9H-carbazole and 1-methyl-9H-carbazole, generated from TiO 2 photocatalysis of DCF were identified by liquid chromatography-mass spectrometry (LCMS) and Fourier transform-ion cyclotron resonance-mass spectrometry (FT-ICR-MS). This work has shown that photocatalytic degradation kinetics of DCF are dependent on both the geometry of the photoreactor and the nature of the water matrices.

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Section: Introductionmentioning

confidence: 99%

Photolysis and TiO2-catalysed degradation of diclofenac in surface and drinking water using circulating batch photoreactors

Kanakaraju¹,

Cherie²,

Motti³

et al. 2014

Environ. Chem.

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“…4 Diclofenac is considerably stable under normal environmental conditions and the most probable decomposition pathway for its onsite elimination is photodecomposition. [5][6][7][8] Investigation of the photolysis of labile environmental pharmaceutical contaminants is important in environmental chemistry because it presents basic data on their fates and persistence in natural environments exposed to sunlight action. 9 Cyclodextrins (CDs) are cyclic oligosaccharides made up of six to eight α-D-glucose units connected through glycosidic-α-1,4-bonds.…”

Section: Introductionmentioning

confidence: 99%

Photochemical characteristics of diclofenac and its photodegradation of inclusion complexes with β-cyclodextrins

Qin¹,

Yang²,

Chen³

et al. 2012

Quím. Nova

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Recebido em 3/7/11; aceito em 29/9/11; publicado na web em 6/12/11 Diclofenac is one of most frequently detected compounds in the water cycle. In this work, the effect of initial concentration, liquid inclusion complexes with β-Cyclodextrins (β-CDs) on the photodegradation of diclofenac were studied. Six phototransformation products were detected by HPLC chromatograms. UV-absorption spectra of diclofenac and phototransformation products were determined. One of the phototransformation products was identified. The degradation followed pseudo-first-order kinetics. The experiment showed that irradiation of diclofenac in the presence of β-CDs increase photodegradation rate and determined the optimal molar ratio of diclofenac to β-CDs as 1:2. The reduced photohaemolytic activity of diclofenac in the presence of β-CDs may be attributed to the sequestering and stabilizing of the radical intermediates and /or photoproducts by complexation.

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“…Des études ont évalué le comportement des composés sous irradiation solaire réelle ou simulée à partir d'expériences effectuées avec des composés dissous dans l'eau purifiée ou dans des eaux naturelles. Ces études indiquent que le diclofénac (ANDREOZZI et al, 2003;BUSER et al, 1998;PACKER et al, 2003) et le naproxen (LIN et REINHARD, 2005;PACKER et al, 2003) sont assez rapidement photolysés sous irradiation solaire et beaucoup plus rapidement dégradés que les deux estrogènes (LIN et REINHARD, 2005).…”

Section: Introductionunclassified

Cinétique de phototransformation de polluants organiques émergents en solution aqueuse diluée

Meite

Szabó

Mazellier

et al. 2010

rseau

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Les vitesses de phototransformation de quatre hormones (estradiol, éthinylestradiol, progestérone, testostérone) et de deux anti-inflammatoires non stéroïdiens (diclofénac et naproxen) ont été étudiées en milieu aqueux dilué. Les expériences de photolyse ont été réalisées sous irradiation monochromatique (254 nm) et sous irradiation polychromatique (λ > 280 nm). Les résultats expérimentaux ont montré que les rendements quantiques de photodécomposition sont faibles (entre 0,02 et 0,08) à l’exception du diclofénac (de l’ordre de 0,30). L’influence de la concentration en oxygène dissous sur les rendements quantiques de photolyse a aussi été examinée. À partir des résultats obtenus, les rendements d’élimination des composés étudiés dans les conditions de désinfection des eaux par irradiation UV à 254 nm ont été estimés.The photodecomposition of some emerging organic pollutants (4 hormones: estradiol, ethynylestradiol, progesterone, testosterone; and 2 nonsteroidal anti-inflammatory drugs: diclofenac and naproxen) has been investigated in dilute aqueous solution. The photolysis experiments were carried out under monochromatic irradiation (254 nm) and under polychromatic irradiation (λ > 280 nm). The calculated quantum yields of photodecomposition under monochromatic irradiations were low (between 0.02 and 0.08) except for diclofenac for which the value was about 0.30. The influence of oxygen concentration was also examined and the removal yields of these compounds under the conditions used for the UV-disinfection of drinking water at 254 nm were estimated

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Photochemical fate of pharmaceuticals in the environment: Naproxen, diclofenac, clofibric acid, and ibuprofen

Cited by 394 publications

References 46 publications

Photolysis and TiO2-catalysed degradation of diclofenac in surface and drinking water using circulating batch photoreactors

Photolysis and TiO2-catalysed degradation of diclofenac in surface and drinking water using circulating batch photoreactors

Photochemical characteristics of diclofenac and its photodegradation of inclusion complexes with β-cyclodextrins

Cinétique de phototransformation de polluants organiques émergents en solution aqueuse diluée

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