Photochemical properties of new bis-cyanine dye as a promising agent for in vivo imaging

Kostyukov, Alexey A.; Egorov, Anton E.; Mestergazi, Mikhail G.; Shmykova, Anna M.; Podrugina, T. A.; Borissevitch, Iouri; Shtil, Alexander А.; Кузьмин, В. А.

doi:10.1016/j.mencom.2020.07.012

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…56,57 Common organic small molecules include indocyanine green (ICG), indole IR780, IR820, IR825, cypate, porphyrin, and aggregation-induced emission luminogens (AIEgens). 58,59 Due to its good water solubility, excellent mitochondrial targeting, and excellent photothermal conversion efficiency (PCE), ICG has shown great potential in PTT, PDT, and FLI. In addition, ICG has excellent biosafety and has been approved by the US Food and Drug Administration for direct clinical imaging diagnosis.…”

Section: Molecular Pharmaceuticsmentioning

confidence: 99%

“…More importantly, small molecular photothermal agents generally have FLI function and have unique advantages in the field of bioimaging. However, biological stability of organic small molecules is poor, and they can be modified and functionalized to enhance stability while diversifying functions. , Common organic small molecules include indocyanine green (ICG), indole IR780, IR820, IR825, cypate, porphyrin, and aggregation-induced emission luminogens (AIEgens). , …”

Section: Types Of Photothermal Agents Commonly Used In Pttmentioning

confidence: 99%

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Advances of Photothermal Agents with Fluorescence Imaging/Enhancement Ability in the Field of Photothermal Therapy and Diagnosis

Yuan,

Zhou,

Wang

et al. 2024

Mol. Pharmaceutics

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Photothermal therapy (PTT) is an effective cancer treatment method. Due to its easy focusing and tunability of the irradiation light, direct and accurate local treatment can be performed in a noninvasive manner by PTT. This treatment strategy requires the use of photothermal agents to convert light energy into heat energy, thereby achieving local heating and triggering biochemical processes to kill tumor cells. As a key factor in PTT, the photothermal conversion ability of photothermal agents directly determines the efficacy of PTT. In addition, photothermal agents generally have photothermal imaging (PTI) and photoacoustic imaging (PAI) functions, which can not only guide the optimization of irradiation conditions but also achieve the integration of disease diagnosis. If the photothermal agents have function of fluorescence imaging (FLI) or fluorescence enhancement, they can not only further improve the accuracy in disease diagnosis but also accurately determine the tumor location through multimodal imaging for corresponding treatment. In this paper, we summarize recent advances in photothermal agents with FLI or fluorescence enhancement functions for PTT and tumor diagnosis. According to the different recognition sites, the application of specific targeting photothermal agents is introduced. Finally, limitations and challenges of photothermal agents with fluorescence imaging/enhancement in the field of PTT and tumor diagnosis are prospected.

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Section: Molecular Pharmaceuticsmentioning

confidence: 99%

Section: Types Of Photothermal Agents Commonly Used In Pttmentioning

confidence: 99%

Advances of Photothermal Agents with Fluorescence Imaging/Enhancement Ability in the Field of Photothermal Therapy and Diagnosis

Yuan,

Zhou,

Wang

et al. 2024

Mol. Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Specifically, this is meaningful in the field of organic chemistry and solar energy for applications such as photodynamic therapy, 1 nonlinear optics, 2 optical data storage, 3 laser materials 4,5 and solar and photovoltaic cells. 6,7 Therefore, the development of these compounds is important due to their photosensitivity, resulting from the excitation of electrons that are stimulated in the form of magnetic resonance. This is important for many vital applications.…”

Section: Introductionmentioning

confidence: 99%