Photochemical release of nitric oxide from a regenerable, sol-gel encapsulated Ru–salen–nitrosyl complex

Abstract

Light activation leads to release of NO from a silicate sol-gel material SG-RuNO prepared from the ruthenium complex, [Ru(salen)(OH2)(NO)]+ (salen = N,N'-bis-(salicylidene)ethyl-enediaminato); after photochemical NO photolabilization, SG-RuNO can be regenerated from the spent material via the subsequent reaction with aqueous nitrite.

PAMAM dendrimers functionalized with ruthenium nitrosyl as nitric oxide carriers

“…Silica [21,22], xerogels [23][24][25], liposomes [26,27], nanoparticles [28] and dendrimers [18,29,30], are common examples of matrices that have been used as NO-releasing vehicles [17,31]. Dendrimers are attractive molecules for NO transport, once they can provide a scaffold for storing large amounts of NO on a single framework [18].…”

Chemical and photochemical properties of a ruthenium nitrosyl complex with the N-monosubstituted cyclam 1-(3-Propylammonium)-1,4,8,11-tetraazacyclotetradecane

“…Among the NO donors, ruthenium nitrosyl complexes are particularly attractive because they are stable, can be either water soluble or not, deliver NO at different rates upon activation by reduction at biologically accessible potentials and/or by light irradiation, in either solution or matrices. [14][15][16][17][18]34,[40][41][42][43][44][45][46][47][48][49] These properties can be tuned by the adequate choice of ligands. 14,18 It should be pointed out that interesting biological activities for several of these complexes have already been reported.…”

Photo-Controlled Release of NO and CO with Inorganic and Organometallic Complexes

“…This chromium nitrito complex was designed considering that Cr is an oxophilic metal, and therefore, when nitrite is a ligand, the β-cleavage of the CrO-NO bond may be more favorable than the cleavage of the Cr-ONO bond [54,55]. Changes in the absorbance spectrum when a deaerated solution of CrONO was subjected to long-term photolysis at 436 nm, did indicate the formation of the corresponding 2+ ), the product of NO 2 -aquation; however, the quantum yield was relatively small (0.0092) [17,18,21]. In contrast, when CrONO was photolyzed in aerated solutions at irradiation wavelengths (λ irr ) between 365 and 546 nm, NO was generated at substantially higher quantum yields (Φ NO up to 0.25).…”