PAMAM dendrimers functionalized with ruthenium nitrosyl as nitric oxide carriers

Roveda, Antonio C.; Papa, Thiago Bueno Ruiz; Castellano, Eduardo E.; Franco, Douglas Wagner

doi:10.1016/j.ica.2013.07.009

Cited by 26 publications

(15 citation statements)

References 58 publications

(150 reference statements)

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“…The total amount and half-life (t 1/2 ) of NO release verified for 1 cm 2 of CS-RuNOisn were 49 ± 5 nmol of NO and t 1/2 = 1.65 ± 0.22 h, respectively, which were close to the values obtained for RuNOisn in solution [114]. Such results are in agreement with those of other ruthenium nitrosyl complexes, in which the chemical properties in solution were maintained after immobilization in different matrices [46,115]. Despite the total amount of NO released from the ruthenium nitrosyl (immobilized or in solution) has physiological relevance, this amount was only 2.5-3.5% of the total RuNOisn content used in the assays.…”

Section: Thiol-responsive Nitric Oxide-releasing Materialssupporting

confidence: 87%

“…Light is a noninvasive trigger that can be used for the spatiotemporal control of NO delivery, with the advantage of not strongly affecting physiological parameters, such as temperature, ionic strength, and pH [103]. In this regard, the literature describes different devices capable of NO release induced by light [47,96,97,99,[103][104][105][107][108][109][110][111][112][113][114][115].…”

Section: Thiol-responsive Nitric Oxide-releasing Materialsmentioning

confidence: 99%

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New perspectives on the reactions of metal nitrosyls with thiolates as nucleophiles

Souza

Roveda

Pereira³

et al. 2016

Coordination Chemistry Reviews

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The susceptibility of the nitrosonium ligand (NO +) of metal nitrosyls to nucleophilic attack has been reviewed. The reactions of nitroprusside with thiolate (RS −) nucleophiles (H 2 S, cysteine, glutathione, N-acetylcysteine and others) have been covered, albeit the main focus is on the reactivity of ruthenium nitrosyl ammines (trans-[Ru(NH 3) 4 (L)NO + ] n+) with cysteine and glutathione. Kinetic aspects and reaction products are discussed. Nitric oxide (NO) and nitroxyl (HNO) are the primary and main nitrogen-based products of the reactions with RS −. The final nitrogen based product N 2 O is identified and suggested as the direct product from the dimerization reaction of HNO. The accumulated data strongly suggest that the ratio of [NO]/[HNO] formed is dependent on the [RS − ]/[RSH] ratio, which can be controlled by the experimental conditions. Some aspects of thiol-responsive nitric oxide-releasing materials are also discussed.

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Section: Thiol-responsive Nitric Oxide-releasing Materialssupporting

confidence: 87%

Section: Thiol-responsive Nitric Oxide-releasing Materialsmentioning

confidence: 99%

New perspectives on the reactions of metal nitrosyls with thiolates as nucleophiles

Souza

Roveda

Pereira³

et al. 2016

Coordination Chemistry Reviews

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the case of PAMAM molecules, it is know that these molecules are extensively used to encapsulate NO species [24,25]. Moreover, PAMAM molecules have been combined with porphyrins to improve the encapsulation process and the release of NO in the drug-delivery concept.…”

Section: Resultsmentioning

confidence: 99%

Electrochemical sensor for nitric oxide using layered films composed of a polycationic dendrimer and nickel(II) phthalocyaninetetrasulfonate deposited on a carbon fiber electrode

et al. 2014

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We have developed an electrochemical sensor for nitric oxide that is based on multi-layers of nickel(II) phthalocyaninetetrasulfonate and a polyamidoamine dendrimer assembled on the surface of a carbon-fiber microelectrode. This sensor responds to nitric oxide at a working potential of 800 mV with a sensitivity of 5.54 pA μM‾ 1 which, however, depends on the dendrimer layer position deposited on the microelectrode. The limit of detection is as low as 5.5 μM at a signal-to-noise ratio of 3. The electrode exhibits good selectivity for nitric oxide over common interferents including dopamine, nitrite, hydrogen peroxide, norepinephrine, epinephrine and ascorbic acid.

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“…The utilization of ruthenium nitrosyl complexes of the type trans-[Ru(NO)(NH 3 ) 4 (L)] 3+ for the modification of PAMAM dendrimers has been explored by Franco et al [68,69]. Their motivation is based on the properties of ligands, including the ability to release NO upon oneelectron reduction or light irradiation, water solubility, low cytotoxicity, and stability in aqueous solution in the presence of oxygen [69]. Modified PAMAM dendrimers of generation 0, 2, and 3 were evaluated according to the relaxation effects of ruthenium nitrosyl dendrimers in denuded normotensive rat aortic rings (precontracted with noradrenaline).…”

Section: Dendritic Polymersmentioning

confidence: 99%

Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives

Seabra¹,

Lima²,

Calderón

2015

CTMC

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Nitric oxide (NO) is known to have dichotomous effects on cancer biology, acting as a pro- or antineoplastic agent. Low concentrations of NO are reported to promote tumor growth, whereas high NO influx acts as a potent tumor repressor, leading to cytotoxicity and apoptosis. There is increasing interest in developing NO-releasing materials as potent tumoricidal agents in which high and localized concentrations of NO may be directly released in a sustained manner to the tumor site. Nanomaterials allied to NO donors have emerged as a promising strategy in cancer treatment. In this context, this review summarizes the roles of NO in cancer biology and highlights the therapeutic potential effects of NO-releasing nanomaterials based on polymeric nanoparticles, dendritic polymers, liposomes, silica nanoparticles, metallic nanoparticles and quantum dots in combating tumor cells.

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PAMAM dendrimers functionalized with ruthenium nitrosyl as nitric oxide carriers

Cited by 26 publications

References 58 publications

New perspectives on the reactions of metal nitrosyls with thiolates as nucleophiles

New perspectives on the reactions of metal nitrosyls with thiolates as nucleophiles

Electrochemical sensor for nitric oxide using layered films composed of a polycationic dendrimer and nickel(II) phthalocyaninetetrasulfonate deposited on a carbon fiber electrode

Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives

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