Photocleavage of pDNA by bis-imidazolidino and bis-thioureido proflavines

Cisárikováa, Alžbeta; Abaffy, Pavel; Imrich, Ján; Paulíková, Helena

doi:10.1515/acs-2015-0017

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…After irradiation, cell death was induced by oxidative damage to the lysosomal and mitochondrial membranes. The signs of necrosis, apoptosis and autophagy, which were observed all indicate that photodynamic antitumor therapy with derivatives 11a–e leads to multiple cell death types (Cisáriková et al ., , ).…”

Section: Proflavine Ureas and Thioureas As Novel Acridine Anticancer mentioning

confidence: 99%

A review on acridinylthioureas and its derivatives: biological and cytotoxic activity

2017

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Acridines possess two characteristics that have led many researchers to consider the agents interesting targets for future development as potential farmacophores: the planar acridine skeleton, which is able to intercalate into DNA, and the intense fluorescence of the agents. This review offers a study of the multifunctional character of acridines and the synthesis of novel acridine derivatives, with particular focus being placed on isothiocyanates and their congeners, e.g. thioureas, isothioureas, quaternary ammonium salts and platinum/gold conjugates. The review provides an overview of the structure, spectral properties, DNA binding and biological activity of acridinylthiourea congeners. These acridinylthiourea derivatives display significant cytotoxic activities against different types of cancer cell lines at micromolar concentrations. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Proflavine Ureas and Thioureas As Novel Acridine Anticancer mentioning

confidence: 99%

A review on acridinylthioureas and its derivatives: biological and cytotoxic activity

2017

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A Review on Acridines as Antiproliferative Agents

Aparna

Rajagopal

Varakumar

et al. 2022

MRMC

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Acridine derivatives have been thoroughly investigated and discovered to have multitarget qualities, inhibiting topoisomerase enzymes that regulate topological changes in DNA and interfering with DNA's vital biological function. This article discusses current progress in the realm of novel 9-substituted acridine heterocyclic compounds, including the structure and structure–activity connection of the most promising molecules. The IC50 values of the new compounds against several human cancer cell lines will also be presented in the publication. The review also looks into the inhibition of topoisomerase by polycyclic aromatic compounds. Background: Acridine rings can be found in molecules used in many different areas, including industry and medicine. Nowadays, acridines with anti-bacterial activity are of research interest due to decreasing bacterial resistance. Some acridine derivatives showed antimalarial or antiviral activity. Acridine derivatives were also investigated for anti-tumor activity due to the interaction with topoisomerase II and DNA base pairs. Considering these possible uses of acridine derivatives, this work was made to overview of all significant structure performances for the specific action of these compounds. Objective: To review the activity of acridines as anti-proliferative agents. Design: This review is designed as acridines acting as topoisomerase I and II inhibitors/ poison, Acridines on the G-quadraplux interaction, Acridines with metal complexes, Acridines with quinacrine scaffold, Acridines with sulphur moiety. Conclusion: Although introduced in the 19th century, acridine derivatives are still of scientific interest. In this review, acridine derivatives with various biological activities (antiparasitic, antiviral, anti-bacterial, and antiproliferative) and their structure-activity relationship analyses are presented. Although several mechanisms of their action are known, the only important are discussed here. It can be concluded that the dominant mechanisms are DNA intercalation and interaction with enzymes.

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Photocleavage of pDNA by bis-imidazolidino and bis-thioureido proflavines

Cited by 2 publications

References 13 publications

A review on acridinylthioureas and its derivatives: biological and cytotoxic activity

A review on acridinylthioureas and its derivatives: biological and cytotoxic activity

A Review on Acridines as Antiproliferative Agents

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