Photocurable platelet rich plasma bioadhesives

Fibrillated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces

“…57 PDz composites with platelet-rich plasma (PRP) have been evaluated to improve the biocompatibility ( G ′ 80–120 kPa, AS 10–20 kPa). 27 However, the increased biocompatibility comes as a tradeoff in shelf stability, as all PRP formulations would need to be freshly prepared at the point of application. 27 Comparable to this study was the PDz composite with 350 kDa alginate which exhibited G ′ of 30 kPa and adhesion strength of 8–10 kPa against wet substrates.…”

“…27 However, the increased biocompatibility comes as a tradeoff in shelf stability, as all PRP formulations would need to be freshly prepared at the point of application. 27 Comparable to this study was the PDz composite with 350 kDa alginate which exhibited G ′ of 30 kPa and adhesion strength of 8–10 kPa against wet substrates. 40 Early attempts of mixing biopolymers, such as alginate, with PDz exhibited electrostatic crosslinking, resulting in Bingham Plastics with shear moduli approaching 1 MPa – too stiff for bioadhesives applications.…”

“…21,22 The photocured PDz composites with solute concentration of 50% or greater have adhesion strength of 5-45 kPa against wet tissue substrates. [23][24][25][26][27] The high PDz concentration leads to high cationic density and subsequently osmotic imbalance and cytotoxicity. 28,29 Hence, lower solute concentrations are desired.…”

Ultrafast gelling bioadhesive based on blood plasma and gelatin for wound closure and healing

“…In terms of clinical efficacy and acute wound care, bioinspired materials have gained much attention in the last decade [6]. Recently, Singh et al developed photocurable semisynthetic PRP-based adhesives with hemostatic and anti-inflammatory properties [7]. In another study, Eryilmaz et al investigated the synergistic effects of fibrin tissue adhesive and PRP on wound healing by studying histopathologic changes in rats.…”

Hydrophobic Bioadhesive Composites for Human Motion Detection

“…In CaproGlu, a photocurable cross-linker (aryl-diazirine) is grafted onto the surface of polycaprolactone (PCLT) polymer. Diazirine is an initiator-free covalent cross-linker that is relatively stable under ambient conditions but can be activated via voltage, heat, or UV. − In a more recent study, diazirine-based materials have also been shown to cross-link under visible light (445 nm) . However, activation at 445 nm only occurs in the presence of a catalyst and is reported to be stable in absence of one.…”