Photocurable resin-silica composites with low thermal expansion for 3D printing microfluidic components onto printed circuit boards

Fei, Guanghai; Nie, Lei; Zhong, Lipeng; Shi, Qimin; Hu, Kehui; Parra‐Cabrera, Cesar; Oprins, Herman; Ameloot, Rob; Yang, Shoufeng

doi:10.1016/j.mtcomm.2022.103482

Cited by 9 publications

(9 citation statements)

References 67 publications

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“…In addition to the channel height, we believe that other variables can also influence the effectiveness of the MNP filtration for the proposed microfluidic chip. First, the MNP concentration is crucial to the dynamic range that can be tuned to fit the clinical cutoff value [ 27 , 28 ]. It is essential to obtain enough MNPs to cluster in the reaction chamber.…”

Section: Resultsmentioning

confidence: 99%

“…Both the patterned elastomer surface and the microscope slides were exposed under plasma O 2 (Expanded Plasma Cleaner PDC-002, Harrick Plasma, Ithaca, NY, USA) for 40 s. The patterned elastomer was flipped to the glass substrate and bonded with uniform pressure to all of the surfaces. The microfluidic channel was functionalized using poly(dimethylsiloxane-b-ethylene oxide) (PDMS-b-PEO) as described in detail in [ 27 ]. A permanent magnet with a disc shape (d = 15 mm, supermagnete, Webcraft GmbH, Gottmadingen, Germany) was positioned under the concentrated chamber to collect the labeled biomarkers before the MR sensor measurement.…”

Section: Methodsmentioning

confidence: 99%

“…The 3D printing process offers better reproducibility and a high throughput production of the microstructure for microfluidics [ 24 , 25 ]. Several methods for 3D printing techniques, such as selective laser sintering, the extrusion method, inkjet printing, and stereolithography (SLA), offer a broad spectrum in terms of cost, resolution, roughness, stiffness, and additive materials [ 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Labeling on a Chip of Cellular Fibronectin and Matrix Metallopeptidase-9 in Human Serum

et al. 2022

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We present a microfluidic chip for protein labeling in the human serum-based matrix. Serum is a complex sample matrix that contains a variety of proteins, and a matrix is used in many clinical tests. In this study, the device performance was tested using commercial serum samples from healthy donors spiked with the following target proteins: cellular fibronectin (c-Fn) and matrix metallopeptidase 9 (MMP9). The microfluidic molds were fabricated using micro milling on acrylic and using stereolithography (SLA) three-dimensional (3D) printing for an alternative method and comparison. A simple quality control was performed for both fabrication mold methods to inspect the channel height of the chip that plays a critical role in the labeling process. The fabricated microfluidic chip shows a good reproducibility and repeatability of the performance for the optimized channel height of 150 µm. The spiked proteins of c-Fn and MMP9 in the human serum-based matrix, were successfully labeled by the functionalized magnetic nanoparticles (MNPs). The biomarker labeling occurring in the serum was compared using a simple matrix sample: phosphate buffer. The measured signals obtained by using a magnetoresistive (MR) biochip platform showed that the labeling using the proposed microfluidic chip is in good agreement for both matrixes, i.e., the analytical performance (sensitivity) obtained with the serum, near the relevant cutoff values, is within the uncertainty of the measurements obtained with a simple and more controlled matrix: phosphate buffer. This finding is promising for stroke patient stratification where these biomarkers are found at high concentrations in the serum.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Labeling on a Chip of Cellular Fibronectin and Matrix Metallopeptidase-9 in Human Serum

et al. 2022

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“…Directly printing the "lab portion" on electronics such as printed circuit boards has been of significant interest to the biochemical and 3D printing communities. 8,83,84 The silicone-based self-supporting microfluidics introduced in section 1.2 provided a novel approach to directly align and print microfluidic channels and chambers on prefabricated sensing circuits (Fig. 3b-i).…”

Section: Integrating 3d Printed Microfluidics With Micro-sensing Arraysmentioning

confidence: 99%

3D printed microfluidics: advances in strategies, integration, and applications

Wang

McAlpine

2023

Lab Chip

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“…In recent years, 3D printing has gained popularity as a method for fabricating microfluidic devices due to its capacity to create precise, intricate structures ( Markoski et al, 2021 ; Shan et al, 2021 ; Wang A et al, 2021 ; Wang H et al, 2021 ). This method offers a wide range of material options, including metals, ceramics, and polymers such as PDMS, polycarbonate (PC), PMMA, and acrylonitrile butadiene styrene (ABS) ( Litti et al, 2021 ; Abdalkader et al, 2022 ; Fei et al, 2022 ; Li et al, 2023 ).…”

Section: Manufacturing Techniquesmentioning

confidence: 99%

Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices

Rodríguez

Andrade-Pérez

Vargas

et al. 2023

Front. Bioeng. Biotechnol.

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Microfluidics is an interdisciplinary field that encompasses both science and engineering, which aims to design and fabricate devices capable of manipulating extremely low volumes of fluids on a microscale level. The central objective of microfluidics is to provide high precision and accuracy while using minimal reagents and equipment. The benefits of this approach include greater control over experimental conditions, faster analysis, and improved experimental reproducibility. Microfluidic devices, also known as labs-on-a-chip (LOCs), have emerged as potential instruments for optimizing operations and decreasing costs in various of industries, including pharmaceutical, medical, food, and cosmetics. However, the high price of conventional prototypes for LOCs devices, generated in clean room facilities, has increased the demand for inexpensive alternatives. Polymers, paper, and hydrogels are some of the materials that can be utilized to create the inexpensive microfluidic devices covered in this article. In addition, we highlighted different manufacturing techniques, such as soft lithography, laser plotting, and 3D printing, that are suitable for creating LOCs. The selection of materials and fabrication techniques will depend on the specific requirements and applications of each individual LOC. This article aims to provide a comprehensive overview of the numerous alternatives for the development of low-cost LOCs to service industries such as pharmaceuticals, chemicals, food, and biomedicine.

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Photocurable resin-silica composites with low thermal expansion for 3D printing microfluidic components onto printed circuit boards

Cited by 9 publications

References 67 publications

Labeling on a Chip of Cellular Fibronectin and Matrix Metallopeptidase-9 in Human Serum

Labeling on a Chip of Cellular Fibronectin and Matrix Metallopeptidase-9 in Human Serum

3D printed microfluidics: advances in strategies, integration, and applications

Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices

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