Photodermatitis from ketoprofen with cross‐reactivity to fenofibrate and benzophenones

Abstract

The aim of this study was to evaluate the possibility of cross-reactivity between ketoprofen, fenofibrate and benzophenones because of their structural similarities. Seven patients presenting photodermatitis from ketoprofen underwent patch and photopatch tests. Ketoprofen, fenofibrate, benzophenone 3, benzophenone 10, benzophenone 4, personal medications and topical creams were tested. All patients had positive patch or photopatch tests to ketoprofen and fenofibrate, four patients had positive UVA photopatch tests to benzophenone 3, and two to benzophenone 10. Patients presenting photosensitization to ketoprofen may also have cross-reactivity to fenofibrate and some benzophenones.

Photoallergy

“…Photocontact allergy to ketoprofen seems to induce a number of photo cross-reactions to compounds with structural similarity like benzophenone-3 and the lipid-lowering agent fenofibrate (78,101,102). However, photoallergic reactions to ketoprofen also associate with structurally unrelated compounds like octocrylene (28,84).…”

Ketoprofen Allergic Reactions

“…Coz concluded that the photoallergy is due to benzophenone moiety in ketoprofen or to a closely related thiophene-phenylketone part of the tiaprofenic acid rather than their arylpropionic acid function. Sugiura study concluded that the benzoyl radical, not benzophenone is the key structure for the photosensitization of KP suprofen and tiaprofenic acid and their photocrossreactivities [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] this contradiction is due to the limitation of the speculation from the clinical data. Patients had different personal histories using several kinds of drugs.…”

Case of photosensitivity caused by fenofibrate after photosensitization to ketoprofen

“…1 PPV has traditionally been subdivided into four types (I-IV) according to the type of pigmented lesion accompanying the capillary malformation. 1 PPV has traditionally been subdivided into four types (I-IV) according to the type of pigmented lesion accompanying the capillary malformation.…”

“…1 However, this information is not widely known as much as ketoprofen. 1 However, this information is not widely known as much as ketoprofen.…”

“…3,4 Tiaprofenic acid and suprofen both have a similar structure to ketoprofen. 1,4,5 The action spectrum of ketoprofen photosensitivity is in UVA, whereas that of fenofibrate has been reported in UVA or UVB or both. 1b).…”