Photodermatitis Induced by Chlorpropamide

Abstract

Five diabetic patients developed photodermatitis following the ingestion of 250–500 mg chlorpropamide per day, from 3 weeks to 4 years after the onset of therapy. Four patients developed the rash in August and September and one in December. Four patients were treated successfully by withdrawing chlorpropamide, shielding from sunlight and administering local symptomatic therapy, while the fifth patient had to be given corticosteroids. In four patients, the skin ultimately cleared, but one patient developed a residual leukomelanoderma. In one patient the minimal erythema dose was found to be lowered a few hours after ingesting a small dose of chlorpropamide.

Hautver�nderungen bei Diabetes mellitus

“…Allergische Hautreaktionen auf Sulfonylharnstoffe können sich unter Fortsetzung der Therapie wieder zurückbilden. Sulfonylharnstoffe führen auch zu photoallergischen oder phototoxischen Reaktionen [9].Auch wenn Photo-Patch-Tests negativ sind,sollte als Konsequenz die diabetische Medikation gewechselt werden.…”