Photodynamic activity of water-soluble phthalocyanine zinc(II) complexes against pathogenic microorganisms

Mantareva, Vanya; Kussovski, Vesselin; Ангелов, Иван; Borisova, Ekaterina; Avramov, L.; Schnurpfeil, Günter; Wöhrle, Dieter

doi:10.1016/j.bmc.2007.04.069

Cited by 116 publications

(94 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The reduction relative to the control group was lower (< 0.18 log) than that found by Mantareva et al [28]. This group treated biofilms with tetrakis-(3-methylpyridyloxy)-and tetrakis-(4-sulfophenoxy)-phthalocyanine zinc(II) at a concentration of 1.5 and 6 μM in the dark and observed cytotoxic effects with a reduction of less than 0.50 log for the microorganisms C. albicans, Staphylococcus aureus, and Escherichia coli.…”

Section: Discussioncontrasting

confidence: 70%

“…The photosensitizer used in the present work was a cationic nanostructure of zinc 2,9,16,23-tetrakis(phenylthio)-29H,31H-phthalocyanine (ZnPc) irradiation by a laser with photodynamic activity on biofilms formed by Candida spp., T. mucoides, and K. ohmeri. The analysis of the efficiency of cationic and anionic ZnPc irradiated by argon-pumped dye laser system (60 J cm -2 ) on C. albicans planktonic culture was carried out by Mantareva et al [28]. The cationic ZnPc was more efficient than anionic ZnPc, with total reduction of 10 6 -10 8 cells/ml of C. albicans compared to a 1-2 log reduction of cells, respectively, which is due to the fact that cationic phthalocyanines exhibit better adhesion to the cellular membrane [29].…”

Section: Yeastsmentioning

confidence: 99%

“…They are characterized by far-red wavelength absorption (> 670 nm), long triplet lifetime (∼1 ms), high quantum yields of singlet oxygens (> 0.2), and low dark toxicity [28][29][30]. The main advantage in the use of phthalocyanine as photosensitizer is the fact that this family of dyes could act by the two classical PDI mechanisms of radical production (type I) or singlet oxygen (type II) [31].…”

Section: Introductionmentioning

confidence: 99%

“…The charge of the photosensitizer is an important factor in determining its effective photodynamic action and whether cells uptake it. Gram-negative bacteria and fungi are resistant to anionic and neutral phthalocyanines [28,29]. In this study, the photodynamic action of a nanostructured formulation cationic zinc 2,9,16,23-tetrakis (phenylthio)-29H,31H-phthalocyanine (ZnPc) was used for inactivating biofilms of different Candida species, T. mucoides, and K. ohmeri.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Photodynamic inactivation of biofilms formed by Candida spp., Trichosporon mucoides, and Kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29H, 31H-phthalocyanine (ZnPc)

et al. 2012

View full text Add to dashboard Cite

Kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29H, 31H-phthalocyanine (ZnPc) LASERS IN MEDICAL SCIENCE, LONDON, v. 27, n. 6, pp. 1205-1212, NOV, 2012 ). The biofilm cells were scraped off the well wall, homogenized, and seeded onto Sabouraud dextrose agar plates that were then incubated at 37°C for 48 h. Efficient PDI of biofilms was verified by counting colony-forming units (CFU/ml), and the data were submitted to analysis of variance and the Tukey test (p<0.05).All biofilms studied were susceptible to PDI with statistically significant differences. The strains of Candida genus were more resistant to PDI than emerging pathogens T. mucoides and K. ohmeri. A mean reduction of 0.45 log was achieved for Candida spp. biofilms, and a reduction of 0.85 and 0.84, were achieved for biofilms formed by T. mucoides and K. ohmeri, respectively. Therefore, PDI by treatment with nanostructured formulations cationic zinc 2,9,16,23-tetrakis (phenylthio)-29H, 31H-phthalocyanine (ZnPc) and a laser reduced the number of cells in the biofilms formed by strains of C. albicans and non-Candida albicans as well the emerging pathogens T. mucoides and K. ohmeri.

show abstract

Section: Discussioncontrasting

confidence: 70%

Section: Yeastsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Photodynamic inactivation of biofilms formed by Candida spp., Trichosporon mucoides, and Kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29H, 31H-phthalocyanine (ZnPc)

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Photoinactivation ability of some phthalocyanine derivatives was investigated in works by other authors -disulphonated zinc phthalocyanine [15], disulphonated aluminium phthalocyanine [16][17][18] and (N-methylpyridyloxy)zinc phthalocyanine [12,15,19]. In our study, we compare their effect in comparison with other phthalocyanine compounds.…”

Section: Discussionmentioning

confidence: 99%

In vitro antimicrobial activity of light-activated phthalocyanines

et al. 2013

View full text Add to dashboard Cite

Photoactive Dye‐Loaded Polymer Materials: A New Cutting Edge for Antibacterial Photodynamic Therapy

Elian,

Méallet,

Versace

2024

Adv Funct Materials

View full text Add to dashboard Cite

Healthcare‐associated infections remain a significant health concern, particularly with the emergence of antibiotic resistance. While these antibiotics have saved countless lives, their overuse reduces their efficacy promoting the emergence of multidrug‐resistant (MDR) bacteria. This prompts researchers to explore new alternatives for treating bacteria proliferation. In this context, antibacterial photodynamic therapy (aPDT) has emerged as a promising approach for treating localized infections. It utilizes reactive oxygen species (ROS) as oxidative stress agents, thereby minimizing the risk of developing MDR. The success of aPDT significantly hinges on the careful selection of photosensitizers (PSs) and polymer matrices for the synthesis of polymer‐based photoactive materials. Various light‐absorbing PSs are therefore designed for enhancing ROS production and antimicrobial efficacy. By incorporating PSs into polymer matrices, these materials can harness the light power to generate ROS, destroying bacterial cells upon irradiation. This review aims to provide a comprehensive overview of advancements in this field, specifically focusing on the use of polymer‐based materials. The mechanism of the four main ROS generated in aPDT, the methods used for their detection, and their mode of action against bacteria has been outlined. The recent improvement in polymer‐based aPDT materials and their antibacterial efficacy have been also addressed.

show abstract

Photodynamic activity of water-soluble phthalocyanine zinc(II) complexes against pathogenic microorganisms

Cited by 116 publications

References 26 publications

Photodynamic inactivation of biofilms formed by Candida spp., Trichosporon mucoides, and Kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29H, 31H-phthalocyanine (ZnPc)

Photodynamic inactivation of biofilms formed by Candida spp., Trichosporon mucoides, and Kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29H, 31H-phthalocyanine (ZnPc)

In vitro antimicrobial activity of light-activated phthalocyanines

Photoactive Dye‐Loaded Polymer Materials: A New Cutting Edge for Antibacterial Photodynamic Therapy

Contact Info

Product

Resources

About