Photodynamic inactivation of enveloped virus in protein plasma preparations by solid-phase fullerene-based photosensitizer

Белоусова, И. М.; Kislyakov, I. M.; Muraviova, Tatyana D.; Starodubtsev, A. M.; Kris’ko, T. K.; Селиванов, Е. А.; Sivakova, N P; Golovanova, I.S.; Volkova, S.D.; Штро, Анна А.; Zarubaev, Vladimir V.

doi:10.1016/j.pdpdt.2014.02.009

Cited by 12 publications

(14 citation statements)

References 17 publications

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“…The main application of fullerene suspensions that has been envisaged is to prevent the transmission of viral infections via plasma. 97 Using C 60 as a photosensitizer has been shown to allow full inactivation of enveloped viruses in irradiated plasma.…”

Section: Viral Inactivation Via Photosensitized Production Of Singletmentioning

confidence: 99%

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

2020

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Section: Viral Inactivation Via Photosensitized Production Of Singletmentioning

confidence: 99%

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

2020

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“…Less frequently were the following PS naphthalene derivatives (Azidonaphthalene (AzNAP); 1,5-diazidonaphthalene (DAN); 1,5-Diiodonaphthalene (DINAP), 7.6% (n = 3/39) [ 37 ], oxazolidine (JL103, JL118, JL122), 7.6% (n = 3/39) [ 33 ] and to Amotosalen derivatives (Amotosalen-HCl and Amotosalen) 5% (n = 2/39) [ 52 , 53 ] respectively. The following PS were not grouped, and individually correspond to 2.6% (n = 1/39), such as 5-aminolevulinic acid (ALA) [ 36 ], Solid phase fullerene-based PS (SPFPS) [ 38 ], Ortoquin [ 32 ], Indocyanine green (ICG) [ 50 ], rhodanine derivative (LJ001) [ 33 ], Fotoditazine [ 60 ], Hypericin (Hy) [ 58 ], Diazidobiphenyl derivative (DABIPH) [ 37 ] and benzochlorine derivative (Zn-BC-AM) [ 43 ], Methylene blue (MB) [ 41 , 49 ] and curcumin (CUR) [ 51 , 57 ]. Highlight MB and CUR which were the most frequent PS in analyzed articles.…”

Section: Resultsmentioning

confidence: 99%

“…Tungsten lamp [ 36 , 43 ], Blue LED light [ 51 , 57 ] and LED [ 41 , 45 ], were equivalent to 7.6% (n = 2/26). Finally, Double-sided panels of Edison diodes [ 38 ], Monochromatic yellow light [ 49 ], Infra-red diode lasers [ 50 ], Fluorescent lamp [ 40 ], Red light [ 55 ] and Visible light [ 58 ] were presented 3.8% (n = 1/26).…”

Section: Resultsmentioning

confidence: 99%

“…Successively, the half maximum inhibitory concentration (IC50), presented a rate of 15.3% (n = 4/26) [ 33 , 42 , 56 , 58 ]. Evaluation by titer virus reduction was equivalent to 11.4% (n = 3/26) when represented by logarithmic reduction [ 38 , 39 , 41 ], in other articles the titer virus reduction was quantified in percent, corresponding to 7.6% (n = 2/26) [ 54 , 59 ]. At last, the subsequent techniques were found only once in articles, corresponding to 3.9% (n = 1/26) for crystal violet evaluate [ 36 ], 3.9% (n = 1/26) by flow cytometry (in percent) [ 43 ], 3.9% (n = 1/26) at spot forming unit (SFU) represented by logarithmic reduction [ 52 ], 3.9% (n = 1/26) quantification of the viral genome by real-time polymerase chain reaction (qRT-PCR) [ 50 ], 3.9% (n = 1/26) to immunocytofluorescence counts [ 45 ], 3.9% (n = 1/26) fluorescence microscopy counts [ 48 ], and 3.9% (n = 1/26) quantify by luminescence unit counts [ 37 ] respectively ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

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A systematic review of photodynamic therapy as an antiviral treatment: Potential guidance for dealing with SARS-CoV-2

Conrado

Sakita

Arita

et al. 2021

Photodiagnosis and Photodynamic Therapy

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Background SARS-CoV-2, which causes the coronavirus disease (COVID-19), presents high rates of morbidity and mortality and has affected thousands of people around the world. The search to eliminate SARS-CoV-2 is ongoing and urgent. This systematic review seeks to assess whether photodynamic therapy (PDT) could be effective in SARS-CoV-2 inactivation. Methods The focus question was: Can photodynamic therapy be used as potential guidance for dealing with SARS-CoV-2?”. A literature search, according to PRISMA statements, was conducted in the electronic databases PubMed, EMBASE, SCOPUS, Web of Science, LILACS, and Google Scholar. Studies published from January 2004 to June 2020 were analyzed. In vitro and in vivo studies were included that evaluated the effect of PDT mediated by several photosensitizers on RNA and DNA enveloped and non-enveloped viruses. Results From 27 selected manuscripts, 26 publications used in vitro studies, 24 were exclusively in vitro , and two had in vitro / in vivo parts. Only one analyzed publication was exclusively in vivo . Meta-analysis studies were unfeasible due to heterogeneity of the data. The risk of bias was analyzed in all studies. Conclusion The in vitro and in vivo studies selected in this systematic review indicated that PDT is capable of photoinactivating enveloped and non-enveloped DNA and RNA viruses, suggesting that PDT can potentially photoinactivate SARS-CoV-2.

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“…The technology of separating plasma-derived products is still changing to achieve higher safety and efficacy (14)(15)(16)(17). Among the new techniques to separate human plasmaderived components, still the human plasma fractionation by cold ethanol is the most popular technique to prepare plasma-derived biological drugs (18)(19)(20)(21).…”

mentioning

confidence: 99%

Virus Reduction of Human Plasma-Derived Biological Medicines

Nazari

Jalili

Shahabi

et al. 2017

Jundishapur J Nat Pharm Prod

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Context: Biological plasma-derived medicines play an important role in the treatment and also prevention of many diseases. The technique implemented to produce such medicines should ensure to minimize the risk of pathogen infection. A very crucial step is the removal or inactivation of highly pathogenic plasma viruses, and only achieving the highly pure product is not adequate. Evidence Acquisition: In the current study, a wide range of physical, chemical, and physicochemical methods of virus inactivation and virus removal were studied to minimize the virus contamination risk in plasma-derived medicines. Results: The virus removal or virus inactivation procedures showed that they were the quite effective techniques in pathogen reduction. But, some of these methods such as solvent/detergent were only effective on lipid-enveloped viruses, while other techniques can be effective both for lipid-enveloped and non-enveloped viruses. Conclusions: To inactivate or remove the most range of viruses, at least 2 different virus inactivation or virus removal techniques should be implemented. But, still emerging new pathogens cause a serious challenge in terms of blood safety, and consequently, safety of human plasma-derived medicines.

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Photodynamic inactivation of enveloped virus in protein plasma preparations by solid-phase fullerene-based photosensitizer

Cited by 12 publications

References 17 publications

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

A systematic review of photodynamic therapy as an antiviral treatment: Potential guidance for dealing with SARS-CoV-2

Virus Reduction of Human Plasma-Derived Biological Medicines

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