2015
DOI: 10.1134/s0006297915060097
|View full text |Cite
|
Sign up to set email alerts
|

Photodynamic inactivation of gramicidin channels in bilayer lipid membranes: Protective efficacy of singlet oxygen quenchers depends on photosensitizer location

Abstract: The impact of double bonds in fatty acyl tails of unsaturated lipids on the photodynamic inactivation of ion channels formed by the pentadecapeptide gramicidin A in a planar bilayer lipid membrane was studied. The presence of unsaturated acyl tails protected gramicidin A against photodynamic inactivation, with efficacy depending on the depth of a photosensitizer in the membrane. The protective effect of double bonds was maximal with membrane-embedded chlorin e6-monoethylenediamine monoamide dimethyl ester, and… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
2
0

Year Published

2018
2018
2021
2021

Publication Types

Select...
2
1
1

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(2 citation statements)
references
References 39 publications
0
2
0
Order By: Relevance
“…Recent work suggests that optical exposure induces membrane pore formation that may lead to uniform permeability of lipid vesicles ( Figure 1B). Such photosensitizing processes have been employed to permeabilize membranes to trigger drug release (Massiot et al, 2019), or to inactivate membrane bound proteins (Rokitskaya et al, 2015). Studies show that optical exposure produces oxidative species that result in chemically modified lipid-tails and increase membrane permeability (Bacellar et al, 2018).…”
Section: Introductionmentioning
confidence: 99%
“…Recent work suggests that optical exposure induces membrane pore formation that may lead to uniform permeability of lipid vesicles ( Figure 1B). Such photosensitizing processes have been employed to permeabilize membranes to trigger drug release (Massiot et al, 2019), or to inactivate membrane bound proteins (Rokitskaya et al, 2015). Studies show that optical exposure produces oxidative species that result in chemically modified lipid-tails and increase membrane permeability (Bacellar et al, 2018).…”
Section: Introductionmentioning
confidence: 99%
“…It is believed that one mechanism through which the PDT functions is the lipid peroxidation induced by the singlet oxygen generated in the activation-deactivation of the fluorescent agent. Another mechanism is that of modulating the gramicidin A channels [14].…”
mentioning
confidence: 99%