Photodynamic inactivation of Paracoccidioides brasiliensis helps the outcome of oral paracoccidiodomycosis

Moreira-Santos, Letícia Fernanda; Melo, Nathália Bandeira de; Carli, Marina Lara de; Mendes, Ana Carolina S. C.; Bani, Giulia M. A. C.; Verinaud, Liana; Burger, Eva; Moraes, Gabriel de Oliveira Isac; Pereira, Alessandro Antônio Costa; Brigagão, Maísa R. L.; Hanemann, João Adolfo Costa; Sperandio, Felipe Fornias

doi:10.1007/s10103-017-2193-y

Cited by 10 publications

(6 citation statements)

References 59 publications

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“…However, in the studies included in our review, several antifungals were reported to be effective in the treatment of different clinical forms of the disease, including azole derivatives, sulfonamide derivatives, and amphotericin B. Recently, experimental studies and case reports have revealed that photodynamic therapy can be an ancillary tool in the management of oral PCM, as it presents promising results in terms of accelerating the repair process and providing decontamination, progressively improving wound healing ( 29 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

Oral paracoccidioidomycosis: a retrospective study of 95 cases from a single center and literature review

Oliveira¹,

Arruda²,

Marinho³

et al. 2023

Med Oral

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Background The ecoepidemiological panorama of paracoccidioidomycosis (PCM) is dynamic and still ongoing in Brazil. In particular, data about the oral lesions of PCM are barely explored. The aim of this study was to report the clinicopathological features of individuals diagnosed with oral PCM lesions at an oral and maxillofacial pathology service in Rio de Janeiro, Brazil, in the light of a literature review. Material and Methods A retrospective study was conducted on oral biopsies obtained from 1958 to 2021. Additionally, electronic searches were conducted in PubMed, Embase, Scopus, Web of Science, Latin American and Caribbean Center on Health Sciences Information, and Brazilian Library of Dentistry to gather information from large case series of oral PCM. Results Ninety-five cases of oral PCM were surveyed. The manifestations were more frequent among males ( n =86/90.5%), middle-aged/older adults ( n =54/58.7%), and white individuals ( n =40/51.9%). The most commonly affected sites were the gingiva/alveolar ridge ( n =40/23.4%) and lip/labial commissure ( n =33/19.3%); however, one ( n =40/42.1%) or multiple sites ( n =55/57.9%) could also be affected. In 90 (94.7%) patients, “mulberry-like” ulcerations/moriform appearance were observed. Data from 21 studies (1,333 cases), mostly Brazilian (90.5%), revealed that men (92.4%; male/female: 11.8:1) and individuals in the fifth and sixth decades of life were the most affected (range: 7-89 years), with the gingiva/alveolar ridge, palate, and lips/labial commissure being the sites most frequently affected. Conclusions The features of oral PCM lesions are similar to those reported in previous studies from Latin America. Clinicians should be aware of the oral manifestations of PCM, with emphasis on the clinicodemographic aspects and differential diagnoses, especially considering the phenomenon of the emergence of reported cases in rural and/or urban areas of Brazil. Key words: Fungal infection, mycoses, neglected diseases, oral manifestations, oral medicine, oral mucosa, paracoccidioidomycosis, south american blastomycosis.

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Section: Discussionmentioning

confidence: 99%

Oral paracoccidioidomycosis: a retrospective study of 95 cases from a single center and literature review

Oliveira¹,

Arruda²,

Marinho³

et al. 2023

Med Oral

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“…The efficacy of PDT was demonstrated in recent clinical research on periopathogens, [36][37][38] carious bacteria, 39,40 onychomycosis, 41,42 and paracoccidiodomycosis. 43 Antiviral therapy using laser light, known as photodynamic inactivation (PDI), is based on the same mechanisms as photodynamic antimicrobial chemotherapy (PACT), i.e., non-thermal viral inactivation. We can differentiate 2 types of virus structural damage caused by light -type I and type II photoreactions.…”

Section: Lasers Enhancing Chemical Reactionsmentioning

confidence: 99%

Laser dentistry in daily practice during the COVID-19 pandemic: Benefits, risks and recommendations for safe treatments

Arnabat-Domínguez¹,

Vecchio²,

Todea³

et al. 2021

Adv Clin Exp Med

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The COVID-19 pandemic forced dental professionals to cope with an unexpected challenge and caused an abrupt cessation of conventional care practices. The high degree of contagiousness as well as the diffusion of the virus through the air and droplets via respiratory transmission placed dental professionals at top-level risk of contracting and spreading the disease. General recommendations were announced in different countries, including patient distancing, air ventilation, surface and instrument sanitization, and the wearing of suitable masks and shields. However, many dental treatments are performed using lasers, and some specific precautions must be added to conventional procedures to ensure the advantages of this technology to patients because of the particular tissue-matter interaction effects of laser wavelengths. Based on the literature, the authors evaluated all of using laser wavelengths to analyze the risk and the benefits of using lasers in daily dental practice, and to provide safety recommendations during pandemic. An unrestricted search of indexed databases was performed. Laser use effects were categorized into: 1) explosive processes that produce tissue ablation and aerosol formation; 2) thermal actions that create vaporization and smoke plume; 3) photobiomodulation of the cells; and 4) enhanced chemical activity. Knowledge of the device functions and choice of adequate parameters will reduce aerosol and plume formation, and the application of suction systems with high flow volume and good filtration close to the surgical site will avoid virus dissemination during laser use. In the categories that involve low energy, the beneficial effects of lasers are available and sometimes preferable during this pandemic because only conventional precautions are required. Lasers maintain the potential to add benefits to dental practice even in the COVID-19 era, but it is necessary to know how lasers work to utilize these advantages. The great potential of laser light, with undiscovered limits, may provide a different path to face the severe health challenges of this pandemic.

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“…Until now, aPDT has been utilized for the disinfection of blood products, especially the inactivation of virus in frozen plasma [36–42]. In addition, it is especially useful for the treatment of infections in the mouth (oral), orthopedics, and dermatology [34,43–48].…”

Section: Recent Patents On Light-based Anti-infective Approachesmentioning

confidence: 99%

Recent Patents on Light-Based Anti-Infective Approaches

Ahmed

Fang

Lü

et al. 2018

PRI

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Background Antibiotic resistance is one of the most serious health threats to modern medicine. The lack of potent antibiotics puts us at a disadvantage in the fight against infectious diseases, especially those caused by antibiotic-resistant microbial strains. To this end, an urgent need to search for alternative antimicrobial approaches has arisen. In the last decade, light-based therapy has made significant strides in this fight to combat antibiotic resistance among various microbial strains. This method includes utilizing antimicrobial blue light, antimicrobial photodynamic therapy, and germicidal ultraviolet irradiation, among others. Light-based therapy is advantageous over traditional antibiotics in that it eradicates microbial cells rapidly and the likelihood of light-resistance development by microbes is low. Methods This review highlights the patents on light-based therapy that were filed approximately within the last decade and are dedicated to eradicating pathogenic microorganisms. The primary database that was used for the search was Google Patents. The searches were performed using the keywords including blue light, antimicrobial photodynamic therapy, ultraviolet irradiation, antibiotic resistance, disinfection, bacterium, fungus, and virus. Results Forty-five patents were obtained in our search: 9 patents for the antimicrobial blue light approach, 21 for antimicrobial photodynamic therapy, 11 for UV irradiation, and lastly 4 for other light-based anti-infective approaches. The treatments and devices discussed in this review are interestingly enough able to be used in various different functions and settings, such as dental applications, certain eye diseases, skin and hard surface cleansing, decontamination of internal organs (e.g., the stomach), decontamination of apparel and equipment, eradication of pathogenic microorganisms from buildings and rooms, etc. Most of the devices and inventions introduce methods of destroying pathogenic bacteria and fungi without harming human cells and tissues. Conclusions Light-based antimicrobial approaches hold great promise for the future in regards to treating antibiotic-resistant infections and related diseases.

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Photodynamic inactivation of Paracoccidioides brasiliensis helps the outcome of oral paracoccidiodomycosis

Cited by 10 publications

References 59 publications

Oral paracoccidioidomycosis: a retrospective study of 95 cases from a single center and literature review

Oral paracoccidioidomycosis: a retrospective study of 95 cases from a single center and literature review

Laser dentistry in daily practice during the COVID-19 pandemic: Benefits, risks and recommendations for safe treatments

Recent Patents on Light-Based Anti-Infective Approaches

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