Photodynamic Inactivation of Pathogenic Bacteria in Biofilms Using New Synthetic Bacteriochlorin Derivatives

Тиганова, И. Г.; Макарова, Е. А.; Меерович, Г. А.; Алексеева, Н. В.; Толордава, Э. Р.; Жижимова, Ю. С.; Лукьянец, Е. А.; Романова, Ю М

doi:10.24931/2413-9432-2017-6-4-27-36

Cited by 13 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ВсН-4А and ВсН-4G have significantly lower MBC for planktonic Gram-positive S. aureus bacteria and Gram-negative bacteria P. aeruginosa as compared with PS based on the cationic bacteriochlorins proposed and investigated before [23][24][25][26][27]. We may suppose that the smaller molecules have more chance to penetrate into bacteria and this is a reason for high efficacy of ВсН-4А and ВсН-4G.…”

Section: Resultsmentioning

confidence: 99%

“…Technological approaches proposed in [19][20][21][22][23] allow the cationic derivatives of synthetic bacteriochlorines to be created with charges number from +4 to +8. The studies conducted on tetracationic and octocationic derivatives [24,25] with a molecular weight of about 1500-1800 Da showed [26,27] that the PS can be used for the photodynamic inactivation (PDI) of Gram-positive bacteria S. aureus and Gram-negative bacteria P. aeruginosa. For these PS the values of their minimal bactericidal concentration (MBC) were determined, which completely prevented growth of bacteria.…”

Section: Photosensitizers For Antibacterial Photodynamic Therapy Base...mentioning

confidence: 99%

See 1 more Smart Citation

Photosensitizers for antibacterial photodynamic therapy based on tetracationic derivatives of synthetic bacteriochlorins

et al. 2018

View full text Add to dashboard Cite

Antibacterial photodynamic therapy is a promising method of treating local infected foci, in particular, surgical and burn wounds, trophic and diabetic ulcers. Both Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Pseudomonas aeruginosa are found in most infected wounds. Photodynamic inactivation (PDI) is able to effectively destroy bacterial cells without developing resistance in response to treatment. This work is dedicated to the study of photophysical and antibacterial properties of new photosensitizers based on tetracationic synthetic bacteriochlorins with a reduced size of the molecule and molecular weight for PDI of S. aureus and P. aeruginosa bacteria and their biofilms.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Photosensitizers For Antibacterial Photodynamic Therapy Base...mentioning

confidence: 99%

Photosensitizers for antibacterial photodynamic therapy based on tetracationic derivatives of synthetic bacteriochlorins

et al. 2018

View full text Add to dashboard Cite

show abstract

“…For photodynamic inactivation of viruses, visible and nearinfrared light sources are used including lamps, LEDs and lasers. Halogen lamp with collimated light beam [21], Xe-arc lamps with ceramic [22] or tunable interference filters [23] can be used to excite various photosensitizers (PSs) and upconversion nanoparticles (UNPs) for biomedical studies. But the most promising are inexpensive, compact, energy-efficient sources of quasi-monochromatic light based on modern LEDs [24] which give a power density of up to 40-50 mW cm −2 .…”

Section: Introductionmentioning

confidence: 99%

Photoinactivation of coronaviruses: going along the optical spectrum

et al. 2020

View full text Add to dashboard Cite

The COVID-19 pandemic has updated research on inactivation of coronaviruses with physical, chemical, and physical-chemical treatments. The review focuses on the inactivation of coronaviruses including the recent SARS-CoV-2 and viruses of other groups with analogous structure using optical radiation. The antiviral effects of different optical ranges from vacuum ultraviolet to infrared radiation are described in terms of the mechanisms of virus photoinactivation, sensitive molecular targets and efficacy. Direct and photosensitized damaging effects of light on the viral molecular structures are considered. Information on the applied pathogen photoinactivation technologies and the advantages of light sources for future applications is provided.

show abstract

“…Technological approaches proposed in [16][17][18][19][20][21][22] allow the cationic derivatives of synthetic bacteriochlorins to be created with charge numbers from +4 to +8. The studies conducted on tetracationic and octacationic derivatives [21,22] with a molecular mass of about 1500-1800 Da showed that the PS can be used for the PDI of Gram-positive bacteria S. aureus and Gram-negative bacteria P. aeruginosa [23,24]. The absorption spectra of synthetic bacteriochlorins have a dome shape at the wavelength near 760 nm with a spectral width of about 20 nm.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic inactivation of Pseudomonas aeruginosa bacterial biofilms using new polycationic photosensitizers

et al. 2019

View full text Add to dashboard Cite

The treatment of infected, long-term, non-healing, complicated wounds of the skin and mucosa, trophic ulcers, pressure sores and ulcers of diabetic feet represents a serious problem, especially in the case of resistant and multi-resistant pathogens. Antibacterial photodynamic therapy can be a promising method of local infected foci treatment of such diseases.This work is devoted to the study of the possibility of photodynamic inactivation (PDI) of Pseudomonas aeruginosa bacteria in the form of biofilms with the help of new polycationic photosensitizers (PSs) based on octacationic phthalocyanine and tetra-and octabacteriochlorins (ZnPcChol 8 , (3-PyBrE) 4 BCBr 4 and (3-PyEPy) 4 BCBr 8 ). More specifically, this work aims to clarify the role of light irradiation in PDI with the participation of new PSs, which has not been fully studied, especially with respect to the comparison of different PS types.

show abstract

Photodynamic Inactivation of Pathogenic Bacteria in Biofilms Using New Synthetic Bacteriochlorin Derivatives

Cited by 13 publications

References 1 publication

Photosensitizers for antibacterial photodynamic therapy based on tetracationic derivatives of synthetic bacteriochlorins

Photosensitizers for antibacterial photodynamic therapy based on tetracationic derivatives of synthetic bacteriochlorins

Photoinactivation of coronaviruses: going along the optical spectrum

Photodynamic inactivation of Pseudomonas aeruginosa bacterial biofilms using new polycationic photosensitizers

Contact Info

Product

Resources

About