Photodynamic therapeutic activity of indocyanine green entrapped in polymeric nanoparticles

El‐Daly, Sherien M.; Gamal‐Eldeen, Amira M.; Abo-Zeid, Mona A.M.; Borai, Ibrahim H.; Wafay, Hanaa; Abdel-Ghaffar, Abdel-Rahman B.

doi:10.1016/j.pdpdt.2012.08.003

Cited by 44 publications

(24 citation statements)

References 42 publications

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“…6). Importantly, the LM exhibited superior photothermal stability than a representative organic dye molecule (indocyanine green: ICG) that are normally used in NIR laser-promoted photodynamic therapy3435. Indeed, any degradation in optical absorbance of LM against laser irradiation was not observed over a monitoring period of 1 h laser exposure in air (Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Light-driven liquid metal nanotransformers for biomedical theranostics

et al. 2017

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Room temperature liquid metals (LMs) represent a class of emerging multifunctional materials with attractive novel properties. Here, we show that photopolymerized LMs present a unique nanoscale capsule structure characterized by high water dispersibility and low toxicity. We also demonstrate that the LM nanocapsule generates heat and reactive oxygen species under biologically neutral near-infrared (NIR) laser irradiation. Concomitantly, NIR laser exposure induces a transformation in LM shape, destruction of the nanocapsules, contactless controlled release of the loaded drugs, optical manipulations of a microfluidic blood vessel model and spatiotemporal targeted marking for X-ray-enhanced imaging in biological organs and a living mouse. By exploiting the physicochemical properties of LMs, we achieve effective cancer cell elimination and control of intercellular calcium ion flux. In addition, LMs display a photoacoustic effect in living animals during NIR laser treatment, making this system a powerful tool for bioimaging.

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Section: Resultsmentioning

confidence: 99%

Light-driven liquid metal nanotransformers for biomedical theranostics

et al. 2017

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“…The laser impact on the cells death after irradiation was evaluated by MTT assay According to the [25,26], first, the MTT solution was prepared by mixing fresh culture medium and 2 mg/mL methyl-thiazolyl-tetrazolium, MTT (Sigma-Aldrich, USA) with the ratio of 3:1 μL. Next, 200 μL of the prepared MTT solution was added to the cell medium in each well.…”

Section: Experimental Designmentioning

confidence: 99%

Effects of continuous wave and fractionated diode laser on human fibroblast cancer and dermal normal cells by zinc phthalocyanine in photodynamic therapy: A comparative study

Navaeipour

Afsharan

Tajalli

et al. 2016

Journal of Photochemistry and Photobiology B: Biology

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“…It is approved by US‐FDA for various clinical applications . Examples of Type II nanoconstructs with encapsulated ICG include poly(allylamine hydrochloride), dextran, and PLCL‐Poloxomer‐based nanoparticles synthesized through electrostatic assembly, poly(lactide‐co‐glycolide (PLGA)) nanoparticles synthesized via spontaneous emulsification solvent diffusion (SESD) or double emulsion method, ormosil PEBBLES using sol–gel combined emulsion polymerization and Eudragit‐based nanoparticles synthesized via precipitation method . Kim and coworkers synthesized ICG‐encapsulated pluronic nanoparticles via solvent evaporation method and intravenously administered the nanoconstruct in mice bearing CT‐26 colon carcinoma .…”

Section: Type IImentioning

confidence: 99%

Polymeric nanoparticles for molecular imaging

Srikar

Upendran

Kannan

2014

WIREs Nanomed Nanobiotechnol

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Conventional imaging technologies (X-ray computed tomography, magnetic resonance, and optical) depend on contrast agents to visualize a target site or organ of interest. The imaging agents currently used in clinics for diagnosis suffer from disadvantages including poor target specificity and in vivo instability. Consequently, delivery of low concentrations of contrast agents to region of interest affects image quality. Therefore, it is important to selectively deliver high payload of contrast agent to obtain clinically useful images. Nanoparticles offer multifunctional capabilities to transport high concentrations of imaging probes selectively to diseased site inside the body. Polymeric nanoparticles, incorporated with contrast agents, have shown significant benefits in molecular imaging applications. These materials possess the ability to encapsulate different contrast agents within a single matrix enabling multimodal imaging possibilities. The materials can be surface conjugated to target-specific biomolecules for controlling the navigation under in vivo conditions. The versatility of this class of nanomaterials makes them an attractive platform for developing highly sensitive molecular imaging agents. The research community's progress in the area of synthesis of polymeric nanomaterials and their in vivo imaging applications has been noteworthy, but it is still in the pioneer stage of development. The challenges ahead should focus on the design and fabrication of these materials including burst release of contrasts agents, solubility, and stability issues of polymeric nanomaterials.

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Photodynamic therapeutic activity of indocyanine green entrapped in polymeric nanoparticles

Cited by 44 publications

References 42 publications

Light-driven liquid metal nanotransformers for biomedical theranostics

Light-driven liquid metal nanotransformers for biomedical theranostics

Effects of continuous wave and fractionated diode laser on human fibroblast cancer and dermal normal cells by zinc phthalocyanine in photodynamic therapy: A comparative study

Polymeric nanoparticles for molecular imaging

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