Photodynamic therapy activity of zinc phthalocyanine linked to folic acid and magnetic nanoparticles

Matlou, Gauta Gold; Oluwole, David O.; Prinsloo, Earl; Nyokong, Tebello

doi:10.1016/j.jphotobiol.2018.07.025

Cited by 30 publications

(11 citation statements)

References 44 publications

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“…Nanomaterials have been studied for these particular therapeutic and diagnostic applications due to their possessing some specific properties, such as small size, biocompatibility, wide chemical affinity, non-toxicity, and also a broad range of prospective modifications, which would allow a further increase in their desired functionality [13]. In PDT, the magnetic properties of magnetite (Fe 3 O 4 ) nanoparticles can be applied for the improvement to the localization of the therapeutic agents in tumor cells [14]. A combined therapy, using photoactive compounds and non-toxic nanoparticles, can be considered as interesting modality aiming to meet this challenge.…”

Section: Introductionmentioning

confidence: 99%

Photosensitizing potential of tailored magnetite hybrid nanoparticles functionalized with levan and zinc (II) phthalocyanine

Chełminiak-Dudkiewicz

Rybczyński

Smolarkiewicz-Wyczachowski

et al. 2020

Applied Surface Science

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Phototherapies, including photodynamic therapy (PDT), have been widely used in the treatment of various diseases, especially for cancer. However, there is still a lack of effective, safe photosensitizers that would be well tolerated by patients. The combination of several methods (like phototherapy and hyperthermia) constitutes a modern therapeutic approach, which demands new materials based on components that are non-toxic without irradiation. Therefore, this study presents the synthesis and properties of novel, advanced nanomaterials in which the advantage features of the magnetic nanoparticles and photoactive compounds were combined. The primary purpose of this work was the synthesis of magnetic nanoparticles coated with biocompatible and antitumor polysaccharide-levan, previously unknown from scientific literature, and the deposition of potent photosensitizerzinc(II) phthalocyanine on their surface. In order to better characterize the nature of the coating covering the magnetic core, the atomic force microscope analysis, a contact angle measurement, and the mechanical properties of pure levan and its blend with zinc(II) phthalocyanine films were investigated. This magnetic nanomaterial revealed the ability to generate singlet oxygen upon exposure to light. Finally, preliminary toxicity of obtained nanoparticles was tested using the Microtox® testwith and without irradiation.

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Section: Introductionmentioning

confidence: 99%

Photosensitizing potential of tailored magnetite hybrid nanoparticles functionalized with levan and zinc (II) phthalocyanine

Chełminiak-Dudkiewicz

Rybczyński

Smolarkiewicz-Wyczachowski

et al. 2020

Applied Surface Science

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“…Many studies related to hybrids have described the chemical interaction between phthalocyanine molecules and solid-state nanoparticles occurring through phthalocyanine’s peripheral functional groups that can anchor the particles’ surfaces [24,25,26,27]. Other reports have addressed a physical interaction, including alkyl chains in the phthalocyanine peripheral structure [28,29,30].…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials Based on Fe3O4 and Phthalocyanines Derived from Cashew Nut Shell Liquid

et al. 2019

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In this work we report the synthesis of new hybrid nanomaterials in the core/shell/shell morphology, consisting of a magnetite core (Fe3O4) and two consecutive layers of oleic acid (OA) and phthalocyanine molecules, the latter derived from cashew nut shell liquid (CNSL). The synthesis of Fe3O4 nanoparticle was performed via co-precipitation procedure, followed by the nanoparticle coating with OA by hydrothermal method. The phthalocyanines anchorage on the Fe3O4/OA core/shell nanomaterial was performed by facile and effective sonication method. The as obtained Fe3O4/OA/phthalocyanine hybrids were investigated by Fourier transform infrared spectroscopy, X-ray diffraction, UV-visible spectroscopy, transmission electron microscopy (TEM), thermogravimetric analysis and magnetic measurements. TEM showed round-shaped nanomaterials with sizes in the range of 12–15 nm. Nanomaterials presented saturation magnetization (Ms) in the 1–16 emu/g and superparamagnetic behavior. Furthermore, it was observed that the thermal stability of the samples was directly affected by the insertion of different transition metals in the ring cavity of the phthalocyanine molecule.

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“…The dark toxicity of this MNP PS carrier noted a significant decrease after attachment of the FA complex [69]. The in vitro MCF-7 PDT effect of Pc-AMNPs noted a significant 60% cell death under 670 nm irradiation, when compared to Pc-FA, which only reported a 40% cell death [69].…”

Section: Magnetic Nanoparticlesmentioning

confidence: 89%

“…Within a study conducted by Matlou et al (2018) the aim was to assess the PDT activity of two zinc phthalocyanine (Pc) derivatives: Zn mono cinnamic acid phthalocyanine and zinc mono carboxyphenoxy phthalocyanine complexes, which were covalently linked to a FA targeting agent and an amino functionalized Fe2O3 MNP (AMNPs) [69]. The dark toxicity of this MNP PS carrier noted a significant decrease after attachment of the FA complex [69]. The in vitro MCF-7 PDT effect of Pc-AMNPs noted a significant 60% cell death under 670 nm irradiation, when compared to Pc-FA, which only reported a 40% cell death [69].…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Inorganic Nanoparticles Applied for Active Targeted Photodynamic Therapy of Breast Cancer

2021

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Photodynamic therapy (PDT) is an alternative modality to conventional cancer treatment, whereby a specific wavelength of light is applied to a targeted tumor, which has either a photosensitizer or photochemotherapeutic agent localized within it. This light activates the photosensitizer in the presence of molecular oxygen to produce phototoxic species, which in turn obliterate cancer cells. The incidence rate of breast cancer (BC) is regularly growing among women, which are currently being treated with methods, such as chemotherapy, radiotherapy, and surgery. These conventional treatment methods are invasive and often produce unwanted side effects, whereas PDT is more specific and localized method of cancer treatment. The utilization of nanoparticles in PDT has shown great advantages compared to free photosensitizers in terms of solubility, early degradation, and biodistribution, as well as far more effective intercellular penetration and uptake in targeted cancer cells. This review gives an overview of the use of inorganic nanoparticles (NPs), including: gold, magnetic, carbon-based, ceramic, and up-conversion NPs, as well as quantum dots in PDT over the last 10 years (2009 to 2019), with a particular focus on the active targeting strategies for the PDT treatment of BC.

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Photodynamic therapy activity of zinc phthalocyanine linked to folic acid and magnetic nanoparticles

Cited by 30 publications

References 44 publications

Photosensitizing potential of tailored magnetite hybrid nanoparticles functionalized with levan and zinc (II) phthalocyanine

Photosensitizing potential of tailored magnetite hybrid nanoparticles functionalized with levan and zinc (II) phthalocyanine

Nanomaterials Based on Fe3O4 and Phthalocyanines Derived from Cashew Nut Shell Liquid

Inorganic Nanoparticles Applied for Active Targeted Photodynamic Therapy of Breast Cancer

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