Photodynamic therapy for lung cancers based on novel photodynamic diagnosis using talaporfin sodium (NPe6) and autofluorescence bronchoscopy

Outcome of Photodynamic Therapy Using NPe6 for Bronchogenic Carcinomas in Central Airways >1.0 cm in Diameter

“…Evaluation of tumor extent and tumor depth is very important to the success of PDT (6,11,13). We previously assessed the usefulness of a photodynamic diagnosis (PDD) system consisting of autofluorescence bronchoscopy SAFE-3000 (14) and NPe6 as a means of accurately defining the tumor margin before PDT (13).…”

“…We previously assessed the usefulness of a photodynamic diagnosis (PDD) system consisting of autofluorescence bronchoscopy SAFE-3000 (14) and NPe6 as a means of accurately defining the tumor margin before PDT (13). Although it was difficult to clearly identify tumor extent and to accurately radiate the tumor, we were able to clearly detect red fluorescence emanating from the tumor with the PDD system before PDT, and the PDD system consisting of SAFE-3000 and NPe6 allowed more accurate assessment of the tumor margin and the quality and efficacy of PDT (13).…”

“…13,14) and tumor depth by OCT, and we retrospectively evaluated the antitumor effect of NPe6 on tumors >1.0 cm in diameter to revise our indications for PDT and propose a new strategy for the treatment of centrally located lung cancers.…”

Follow-up using fluorescence bronchoscopy for the patients with photodynamic therapy treated early lung cancer

“…The thickened type is characterized by superficial lesions manifested by subtle mucosal changes on the bronchial surface, and it is the predominant type (14)(15)(16)(17). Of the 16 lesions examined in this study, 11 of them were the thickened type, 4 lesions were nodular type and 1 was the polypoid type.…”

“…The Japanese Lung Cancer Society classifies CLELCs on the basis of the endoscopic findings into a thickened type, polypoid type, and nodular type (14)(15)(16)(17). The thickened type is characterized by superficial lesions manifested by subtle mucosal changes on the bronchial surface, and it is the predominant type (14)(15)(16)(17).…”