Photodynamic Therapy for Symptomatic Circumscribed Macular Choroidal Hemangioma in Chinese Patients

Zhang, Yongjin; Liu, Wei; You, Fang; Jiao, Qian; Xu, Gezhi; Wang, Wenji; Li, Lei; Shen, Ying; Qiaoyun, Gao

doi:10.1016/j.ajo.2010.05.016

Cited by 36 publications

(25 citation statements)

References 16 publications

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“…A single application of PDT using currently prescribed parameters is insufficient to destroy the enlarged vessels. This experience is similar to previous reports from China describing circumscribed choroidal hemangiomas 4. The decision for repeat treatment was based on subretinal fluid recurrence, rather than on complete tumor regression.…”

Section: Discussionsupporting

confidence: 86%

Multifocal photodynamic therapy for diffuse choroidal hemangioma

Ang

Lee²

2012

OPTH

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BackgroundA choroidal hemangioma is an uncommon benign vascular tumor of the choroid that can be either circumscribed or diffuse. In our experience, diffuse choroidal hemangiomas in Asian patients often require multiple photodynamic therapy (PDT) treatment sessions.MethodsWe here provide a case report of a 7-year-old boy with Sturge–Weber syndrome who presented with diffuse choroidal hemangioma in the left eye. Five sessions of PDT treatment were required over a period of 1 year and a final optical coherence tomogram 3 months later revealed resolution of subretinal fluid and the choroidal hemangioma.ResultsFinal visual acuity was 20/100 in the left eye with resolution of subretinal fluid. This case report illustrates that a single application of PDT using standard published parameters was insufficient to achieve the destruction of the enlarged vessels. This experience is similar to previous Chinese reports on circumscribed choroidal hemangiomas. The decision for repeat treatment was based on subretinal fluid recurrence, rather than complete tumor regression.ConclusionOur case report supports previous suggestions that larger dilated vessels in the vascular network of a choroidal hemangioma might affect the efficacy and selectivity of PDT in treating the eyes of Asian patients – which may explain the need for multiple treatments.

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Section: Discussionsupporting

confidence: 86%

Multifocal photodynamic therapy for diffuse choroidal hemangioma

Ang

Lee²

2012

OPTH

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“…PDT also targets nonproliferative choroidal vessels. The greater blood volume in the dilated vessels of hemangioma may account for the efficacy of PDT for hemangioma 21,23…”

Section: Discussionmentioning

confidence: 99%

A case of presumed choroidal metastasis from carcinoid tumor treated by photodynamic therapy with verteporfin

Kawakami¹,

Wakabayashi²,

Gotô³

2013

OPTH

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We report a case of metastatic choroidal carcinoid tumor with favorable outcome after photodynamic therapy. A 75-year-old woman was presumptively diagnosed with bilateral choroidal metastases from carcinoid tumor. Although the tumor in the right eye showed a tendency toward rapid expansion and required aggressive treatment to preserve vision, the size was still small and we hesitated to use external-beam radiotherapy because of the risk of radiation retinopathy. Consequently, photodynamic therapy was performed on the right eye, resulting in drastic reduction of the size and height of the choroidal tumor. Good visual acuity was maintained after photodynamic therapy. Photodynamic therapy may be an effective treatment for choroidal metastasis from carcinoid tumor.

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“…Zhang ve ark. 15 25 olguda subfoveal lezyonlarda 50J/cm 2 ve perifoveal lezyonlarda 75J/cm 2 ışık dozunda 1-2 (ortalama 1,08) seans FDT uygulamışlar ve ortalama 35 aylık izlemde ortalama tümör kalınlığı azalırken %28 olguda tam tümör regresyonu olduğunu belirtmişlerdir. Boixadera ve ark.…”

Section: Discussionunclassified

Sınırlı ve Difüz Koroid Hemanjiomlarında Tedavi Sonuçlarımız

Savku¹,

Günduz²

2013

Tjo

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Sum maryPur po se: To discuss our treatment results of choroidal hemangiomas. Ma te ri al and Met hod: The records of 39 cases of choroidal hemangioma followed up at our clinic between July 1999-October 2012 were reviewed retrospectively. Asymptomatic cases were followed up. Symptomatic cases with subretinal fluid and impaired vision received treatment. Re sults: Mean age of the 39 patients was 44 (12-80) years. Thirty-five of 39 cases had circumscribed choroidal hemangioma, and 4 cases had diffuse choroidal hemangioma. Sturge-Weber syndrome was present in 3 cases with diffuse choroidal hemangioma. Cases with circumscribed choroidal hemangioma and minimal subretinal fluid were treated with TTT in 11 cases, PDT in 12 cases, and PDT+TTT in 1 case. Cases with circumscribed choroidal hemangioma and excessive subretinal fluid were treated with Ru-106 plaque radiotherapy in 1 case, Ru-106 plaque radiotherapy+TTT in 1 case, EBRT in 3 cases, and TTT+EBRT in 1 case. One painful blind eye with neovascular glaucoma and complicated cataract was enucleated. Cases with diffuse choroidal hemangioma and excessive subretinal fluid were treated with Ru-106 plaque radiotherapy+TTT in 1 case and EBRT in 1 case. Ahmed glaucoma valve implantation and FAKO emulsification were applied to a case with neovascular glaucoma and complicated cataract. Complete resorption of subretinal fluid was achieved in 23 (72%) of treated 32 cases. When mean initial tumor thickness was 2.6 mm (0.5-6), mean final tumor thickness was 1.4 mm (0-6). When mean initial visual acuity (LogMAR) was 1.5 (0-3), mean final visual acuity was 1.1 (0-3). No recurrence was observed. Dis cus si on: The amount of the subretinal fluid determines the method of treatment in circumscribed choroidal hemangioma. While TTT and PDT are effective treatment modalities for minimal subretinal fluid, plaque radiotherapy and EBRT are applied in cases with excessive subretinal fluid. Combination therapies may be necessary according to the persistence of subretinal fluid. Visual acuity is generally preserved and sometimes improved with treatment. (Turk J Ophthalmol 2013; 43: 216-20)

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Photodynamic Therapy for Symptomatic Circumscribed Macular Choroidal Hemangioma in Chinese Patients

Cited by 36 publications

References 16 publications

Multifocal photodynamic therapy for diffuse choroidal hemangioma

Multifocal photodynamic therapy for diffuse choroidal hemangioma

A case of presumed choroidal metastasis from carcinoid tumor treated by photodynamic therapy with verteporfin

Sınırlı ve Difüz Koroid Hemanjiomlarında Tedavi Sonuçlarımız

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