Photodynamic therapy induces antifibrotic alterations in primary human vocal fold fibroblasts

Zhang, Chi; Wang, Jiajia; Chou, Adriana; Gong, Ting; Devine, Erin E.; Jiang, Jack J.

doi:10.1002/lary.27219

Cited by 17 publications

(23 citation statements)

References 39 publications

(110 reference statements)

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“…The sublethal doses of ALA and 580-740 nm light irradiation on human dermal fibroblasts was shown to in vitro induce matrix metalloproteinase 1 and matrix metalloproteinase 3 expression in a singlet oxygen-dependent way while reducing collagen type I mRNA expression[126]. In vitro treatment of primary human vocal fold fibroblasts with sublethal (200µM) ALA-based PDT was shown to significantly alter the expression of genes related to ECM remodelling[127]. Thus, the expressions of TGF-b1, COL1A2, COL3A1, fibronectin and elastin were reduced, while the expression of MMP1 was increased.…”

mentioning

confidence: 99%

Vascular and extracellular matrix remodeling by physical approaches to improve drug delivery at the tumor site

Gouarderes

Mingotaud

Vicendo

et al. 2020

Expert Opinion on Drug Delivery

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Introduction: Modern comprehensive studies of tumour microenvironment changes allowed scientists to develop new and more efficient strategies that will improve anticancer drug delivery on site. The tumour microenvironment, especially the dense extracellular matrix, has a recognised capability to hamper the penetration of conventional drugs. Development and co-applications of strategies aiming at remodelling the tumour microenvironment are highly demanded to improve drug delivery at the  Chemophototherapy, the combination of phototherapy and chemotherapy, is an efficient strategy to induce tumour vascular permeability and ensuing drug delivery to tumours.  Standalone or co-applied physical strategies to disrupt the dense tumour extracellular matrix or to mediate vascular permeability may be of major interest to improve drug delivery at the tumour site in a therapeutic prospect.

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mentioning

confidence: 99%

Vascular and extracellular matrix remodeling by physical approaches to improve drug delivery at the tumor site

Gouarderes

Mingotaud

Vicendo

et al. 2020

Expert Opinion on Drug Delivery

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“…VF fibrosis is the result of the formation of scar tissue on VF lamina propria as a result of damage and can lead to voice disorders. Although scarring is generally important for wound healing, abnormal regenerative events such as excessive scar formation and inflammatory responses can lead to tissue fibrosis (Zhang et al, 2018). Due to excessive scarring, VF lamina propria tissue is replaced by fibrotic tissue with a disorganized ECM (Erndt‐Marino et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Therapeutic approaches to VF fibrosis include scar excision, biomaterial injection or implantation, and localized steroid injection. However, most of these treatments produce inconsistent and unsatisfactory results (Kishimoto et al, 2019; Zhang et al, 2018). Therefore, there is a crucial need to develop a more consistent and effective strategy for VF fibrosis that has minimal side effects.…”

Section: Introductionmentioning

confidence: 99%

Phlorotannins ameliorate extracellular matrix production in human vocal fold fibroblasts and prevent vocal fold fibrosis via aerosol inhalation in a laser‐induced fibrosis model

Kim

Lee

et al. 2020

J Tissue Eng Regen Med

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Vocal fold fibrosis is an abnormal condition characterized by unfavorable changes in the organization of the extracellular matrix in vocal fold lamina propria. To prevent and treat vocal fold fibrosis, a number of synthetic drugs, such as mitomycin C and the glucocorticoid family, are used after surgery, but these are known to have some side effects. Therefore, using both in vitro and in vivo studies, this study investigated whether phlorotannins extracted from Ecklonia cava have the potential to prevent vocal fold fibrosis with minimal side effects. The results show that phlorotannins suppressed both the expression of the fibrotic phenotypic marker and cell migration by inhibiting the activation of the mitogen‐activated protein kinase (MAPK) and Smad2/3 signaling pathways in human vocal fold fibroblasts stimulated by transforming growth factor‐β. Additionally, phlorotannins exhibited antifibrotic efficacy without an excessive inflammatory response in a laser‐induced fibrosis rabbit model when delivered as an aerosol via inhalation. Based on these results, phlorotannins should be considered a promising candidate for use in the prevention of vocal fold fibrosis.

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“…It has also been shown that PDT leads to minimal amounts of scarring, a crucial factor in voice outcomes. 79 However, there are few studies that encompassed voice outcomes. One study led by von Beckerath et al 80 looked at voice quality post PDT treatment of laryngeal cancer using a subjective pre and post-PDT assessment performed by a phonometrist.…”

Section: Clinical Usesmentioning

confidence: 99%

Phonosurgery: A review of current methodologies

Ulmschneider

Baker

Vize

et al. 2021

World j. otorhinolaryngol.-head neck surg.

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Cold‐steel has served as the gold standard modality of phonosurgery for most of its history. Surgical laser technology has revolutionized this field with its wide use of applications. Additional modalities have also been introduced such as coagulative lasers, photodynamic therapy, and cryotherapy. This review will compare the surgical modalities of cold steel, surgical lasers, phototherapy and cryotherapy. The mechanism of action, tissue effects and typical uses will be addressed for each modality.

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Photodynamic therapy induces antifibrotic alterations in primary human vocal fold fibroblasts

Abstract: NA Laryngoscope, 128:E323-E331, 2018.

Cited by 17 publications

References 39 publications

Vascular and extracellular matrix remodeling by physical approaches to improve drug delivery at the tumor site

Vascular and extracellular matrix remodeling by physical approaches to improve drug delivery at the tumor site

Phlorotannins ameliorate extracellular matrix production in human vocal fold fibroblasts and prevent vocal fold fibrosis via aerosol inhalation in a laser‐induced fibrosis model

Phonosurgery: A review of current methodologies

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