Photodynamic therapy mediated by acai oil (Euterpe oleracea Martius) in nanoemulsion: A potential treatment for melanoma

Monge-Fuentes, Victoria; Muehlmann, Luís Alexandre; Longo, João Paulo Figueiró; Silva, Jaqueline R.; Fascineli, Maria Luiza; Souza, Paulo de Oliveira Ponte de Jorge; Faria, Fernando; Degterev, I. A.; Rodriguez, Anselmo Fortunato Ruiz; Carneiro, Fabiana Pirani; Lucci, Carolina Madeira; Escobar, Patricia; Amorim, Rivadávio Fernandes Batista de; Azevedo, Ricardo Bentes

doi:10.1016/j.jphotobiol.2016.12.002

Cited by 93 publications

(69 citation statements)

References 51 publications

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“…Acai showed no toxicity in experimental models [31][32][33][34][35][36] nor any significant differences in the body weight or food consumption [17,31,32,36], suggesting potential applications in the prevention of various disease. Conversely, Mn, which is abundant in acai, suppresses Fe absorption, suggesting a risk for anemia [37].…”

Section: Discussionmentioning

confidence: 96%

Acai Extract Transiently Upregulates Erythropoietin by Inducing a Renal Hypoxic Condition in Mice

et al. 2020

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Acai (Euterpe oleracea Mart. Palmae, Arecaceae) is a palm plant native to the Brazilian Amazon. It contains many nutrients, such as polyphenols, iron, vitamin E, and unsaturated fatty acids, so in recent years, many of the antioxidant and anti-inflammatory effects of acai have been reported. However, the effects of acai on hematopoiesis have not been investigated yet. In the present study, we administered acai extract to mice and evaluated its hematopoietic effects. Acai treatment significantly increased the erythrocytes, hemoglobin, and hematocrit contents compared to controls for four days. Then, we examined the hematopoietic-related markers following a single injection. Acai administration significantly increased the levels of the hematopoietic-related hormone erythropoietin in blood compared to controls and also transiently upregulated the gene expression of Epo in the kidney. Furthermore, in the mice treated with acai extract, the kidneys were positively stained with the hypoxic probe pimonidazole in comparison to the controls. These results demonstrated that acai increases the erythropoietin expression via hypoxic action in the kidney. Acai can be expected to improve motility through hematopoiesis.

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Section: Discussionmentioning

confidence: 96%

Acai Extract Transiently Upregulates Erythropoietin by Inducing a Renal Hypoxic Condition in Mice

et al. 2020

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“…This method is based on the principle that live cells possess intact plasma membranes that exclude the trypan blue dye. The CC 10 indicated the cytotoxic concentration that kills 10% of treated cells (24,25). The 10% cytotoxic concentration (CC 10 ) after 24 h of treatment was calculated using Microsoft Excel software.…”

Section: Determination Of 10% Cytotoxic Concentrationmentioning

confidence: 99%

Antioxidant activity and leukemia initiation prevention in�vitro and in�vivo by N‑acetyl‑L‑cysteine

et al. 2018

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-acetyl-L-cysteine (NAC) is the most abundant water-soluble component of garlic. No study to date has studied the leukemia prevention ability of NAC in mouse systemic leukemia model. The current study aimed to investigate the leukemia initiation prevention potential of NAC in a mouse model. The cytotoxic concentration of NAC was determined first in HL-60 cells, and its activity was studied in a mouse acute myelocytic leukemia model with WEHI-3 leukemia cells. The results showed that a non-toxic concentration of NAC efficiently scavenged free-radicals, lowered lipid peroxidation and reduced DNA damage induced by hydrogen peroxide in a cultured HL-60 leukemia cell line. NAC also elevated the cellular antioxidant enzyme activity significantly. Furthermore, NAC prevented mouse death induced by injection of murine WEHI-3 leukemia cells and reduced organ damage, as well as activated antioxidant mechanisms. The results of this study provided strong evidence that NAC may have potential benefits in terms of elevating antioxidant activity and preventing leukemia initiation.

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“…Results presented the nanoemulsions as potentially effective and promising administration systems for medications. In addition, more recent research also evaluated the photosensitizing efficacy of a new nanoemulsion containing açaí oil to induce melanoma cell death in in vitro and in vivo models . The nanoemulsion was shown to kill 85% of melanoma cells, maintaining high viability in normal cells, and treated mice showed 82% tumor reduction compared with the control group.…”

Section: Main Applicationsmentioning

confidence: 99%

Nanoemulsions and dermatological diseases: contributions and therapeutic advances

et al. 2018

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Skin disease is one of the most common human diseases and affects between 30% and 70% of individuals, which requires a lot of attention to their treatments. The delivery of active pharmacological ingredients at the topical level is a challenge because of the difficulties in overcoming the mechanical barrier created by the skin and reaching greater depths, since delivery specificities are decisive for the degree of effectiveness. In this way, the nanoemulsions emerge as a potential system for the incorporation of active substances in the cells and for the controlled release of active principles. The present article intends to review the main treatments for which the nanoemulsions were used in the field of dermatology. In addition, it discusses the results and advantages over the other dermatological therapies that are being used. The results showed that the particle size in nanoemulsions increased the contact surface area, resulting in increased drug efficacy, even in comparison with other existing pharmaceutical formulations. In conclusion, it has been shown that nanoemulsions have a better performance in efficacy, safety, permeability profile, and bioavailability compared with other formulations studied.

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Photodynamic therapy mediated by acai oil (Euterpe oleracea Martius) in nanoemulsion: A potential treatment for melanoma

Cited by 93 publications

References 51 publications

Acai Extract Transiently Upregulates Erythropoietin by Inducing a Renal Hypoxic Condition in Mice

Acai Extract Transiently Upregulates Erythropoietin by Inducing a Renal Hypoxic Condition in Mice

Antioxidant activity and leukemia initiation prevention in�vitro and in�vivo by N‑acetyl‑L‑cysteine

Nanoemulsions and dermatological diseases: contributions and therapeutic advances

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