PHOTODYNAMIC THERAPY OF B16 PIGMENTED MELANOMA WITH LIPOSOME‐DELIVERED Si(IV)‐NAPHTHALOCYANINE

Biolo, Roberta; Jori, Giulio; Soncin, Marina; Pratesi, Riccardo; Vanni, U.; Rihter, Boris D.; Kenney, M. E.; Rodgers, Michael A. J.

doi:10.1111/j.1751-1097.1994.tb05048.x

Cited by 41 publications

(32 citation statements)

References 9 publications

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“…Our findings suggest that a limited selectivity of melanoma targeting by BPD-MA occurs only at 1-3 h with a concentration ratio of 1.6. In contrast, no selectivity of accumulation in the melanotic melanoma was observed for SiNc (Biolo et al, 1994;Biolo et al, 1996). Both BPD-MA and SiNc were found to give a good selectivity of tumour targeting in other transplanted tumours (Cuomo et al, 1990;Richter et al, 1990).…”

Section: Resultsmentioning

confidence: 99%

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High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma

et al. 1999

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Summary Benzoporphyrin derivative monoacid ring A (verteporfin, BPD-MA) when intravenously injected (5.5 µmol kg -1 ) to C57/BL6 mice bearing a subcutaneously transplanted B1 melanoma gave a maximal accumulation in the tumour within 1-3 h with recoveries of 1.84-1.96 µmol kg -1 . Irradiation of BPD-MA-loaded melanoma with 690-nm light from a dye laser at 3 h and 9 h post injection induced tumour necrosis and delay of tumour growth of 28 and 14 days respectively. The response of the tumour to BPD-MA photosensitization was enhanced by pretreatment with 1064-nm light from a pulse-operated Nd:YAG laser, which caused a selective breakdown of melanosomes.

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Section: Resultsmentioning

confidence: 99%

“…In this connection, BPD-MA is superior to SiNc, whose clearance from the organism is still incomplete 1 week after i.v. injection (Biolo et al, 1994).…”

Section: Resultsmentioning

confidence: 99%

High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma

et al. 1999

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“…(C) Lutetium texaphyrin from (Woodburn, Fan et al 1998). (D) Si(IV)-naphthalocyanine (Isobosinc) from (Biolo, Jori et al 1994). Showing red fluorescence from BC 1, 2 or 3 overlaid with green fluorescence from lysotracker, mitotracker or FITC-anti-TRP1 antibody that stains melanosomes.…”

Section: Resultsmentioning

confidence: 99%

“…PDT of the heavily pigmented metastatic B16F10 melanoma using a diamagnetic water-soluble lutetium texaphyrin (PCI-0123) resulted in tumor apoptosis with a significant tumor regrowth decay and increase of survival (Woodburn, Fan et al 1998). Biolo et al (Biolo, Jori et al 1994) used a liposomal formulation of Si(IV)-naphthalocyanine for induction of tumor necrosis and delay of tumor regrowth in B16 pigmented melanoma, although no tumor selectivity was observed.…”

Section: Near Infrared Absorbing Psmentioning

confidence: 99%

Melanoma resistance to photodynamic therapy: new insights

Huang¹,

Vecchio²,

Avci

et al. 2013

Biological Chemistry

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Melanoma is the most dangerous form of skin cancer, with a steeply rising incidence and a poor prognosis in its advanced stages. Melanoma is highly resistant to traditional chemotherapy and radiotherapy, although modern targeted therapies such as BRAF inhibitors are showing some promise. Photodynamic therapy (PDT, the combination of photosensitizing dyes and visible light) has been tested for melanoma with some promising results, but melanoma is generally considered to also be resistant to PDT. Optical interference by the highly-pigmented melanin, the anti-oxidant effect of melanin, the sequestration of photosensitizers inside melanosomes, defects in apoptotic pathways, and the efflux of photosensitizers by ATP-binding cassette (ABC) transporters have all been implicated in melanoma resistance to PDT. Approaches to overcoming melanoma resistance to PDT include: the discovery of highly active photosensitizers absorbing in the 700-800-nm near infrared spectral region; interventions that can temporarily reduce the amount or the pigmentation of the melanin; compounds that can reverse apoptotic defects or inhibit drug-efflux of photosensitizers; and immunotherapy approaches that can take advantage of the ability of PDT to activate the host immune system to the treated tumor.

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“…The beam was piloted to the irradiation site by a bundle of optical fibres whose tip (diameter 0.8 cm) was kept at a distance of 1 cm from the mouse skin. Previous studies (Soncin et al, 1995b) have shown that under these irradiation conditions the tumour temperature does not rise beyond 38°C, so that any hyperthermal effect could be discounted (Biolo et al, 1994). During irradiation the mice were anaesthetised by intraperitoneal administration of ketalar (0.5 ml per 20 g of body weight).…”

Section: Chemicalsmentioning

confidence: 99%

Tumour-localising and -photosensitising properties of a novel zinc(II) octadecylphthalocyanine

Ometto

Fabris²,

Milanesi³

et al. 1996

Br J Cancer

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Summary 1,4,8,11,15,18,22,, ZnODPc, incorporated into a Cremophor emulsion, was assayed for its pharmacokinetic and phototherapeutic properties in Balb/c mice bearing an intramuscularly transplanted MS-2 fibrosarcoma. The phthalocyanine was injected intravenously (i.v.) in three doses, i.e. 1.46, 0.73 and 0.37 ttmol kg-' body weight. In all cases, the octadecyl-substituted phthalocyanine showed an unusually high affinity for serum low-density lipoproteins (LDLs) and a high efficiency and selectivity of tumour targeting: the maximum accumulation in the tumour occurred at 24 h after injection, whereas no detectable amount of phthalocyanine was recovered from the muscle, i.e. the peritumoral tissue, between I h and 1 week after injection. At the same time, low amounts of phthalocyanine were recovered from skin and then only at short times after injection, with skin photosensitivity rapidly disappearing and the phthalocyanine present in the serum only. Tumour photosensitisation studies were carried out at 24 h after administration of 1.46 ,umol kg-' ZnODPc and showed that this phthalocyanine has a very high phototherapeutic efficiency; this is probably a consequence of the multiple mechanisms by which the phthalocyanine induces tumour damage, involving both direct modification of malignant cells and impairment of blood flow, as well as the alteration of a variety of subcellular components, such as mitochondria, the rough endoplasmic reticulum, the perinuclear membrane and, occasionally, cell nuclei. Tumour necrosis appears to be the consequence of both random cell death and apoptosis.

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PHOTODYNAMIC THERAPY OF B16 PIGMENTED MELANOMA WITH LIPOSOME‐DELIVERED Si(IV)‐NAPHTHALOCYANINE

Cited by 41 publications

References 9 publications

High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma

High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma

Melanoma resistance to photodynamic therapy: new insights

Tumour-localising and -photosensitising properties of a novel zinc(II) octadecylphthalocyanine

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