Photodynamic therapy of cervical intraepithelial neoplasia grades II and III with Photolon®

Istomin, Yu. P.; Lapzevich, Tatsiana P; Chalau, Vadzim; Shliakhtsin, S.V.; Trukhachova, T.V.

doi:10.1016/j.pdpdt.2010.06.005

Cited by 61 publications

(31 citation statements)

References 14 publications

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“…PDT with polyhematoporphyrin ether/ester 2 mg/kg IV for applied for 60 hours and irradiated with 630 nm YAG‐OPO laser improved cytological measures when treating CIN and also eradicated HPV 37. Similar results were obtained when infection was photoinactivated with photolon 38 and 5‐ALA 39. Topical application of 5‐ALA PDT also successfully treated 13 of the 14 cases of anogenital condyloma accuminata 40.…”

Section: Pdt Of Viral Lesionsmentioning

confidence: 59%

Photodynamic therapy for infections: Clinical applications

et al. 2011

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Background and Objective Photodynamic therapy (PDT) was discovered over 100 years ago by its ability to kill various microorganisms when the appropriate dye and light were combined in the presence of oxygen. However it is only in relatively recent times that PDT has been studied as a treatment for various types of localized infections. This resurgence of interest has been partly motivated by the alarming increase in drug resistance amongst bacteria and other pathogens. This review will focus on the clinical applications of antimicrobial PDT. Study Design/Materials and Methods The published peer-reviewed literature was reviewed between 1960 and 2011. Results The basics of antimicrobial PDT are discussed. Clinical applications of antimicrobial PDT to localized viral infections caused by herpes and papilloma viruses, and nonviral dermatological infections such as acne and other yeast, fungal and bacterial skin infections are covered. PDT has been used to treat bacterial infections in brain abscesses and non-healing ulcers. PDT for dental infections including periodontitis and endodontics has been well studied. PDT has also been used for cutaneous Leishmaniasis. Clinical trials of PDT and blue light alone therapy for gastric Helicobacter pylori infection are also covered. Conclusion As yet clinical PDT for infections has been mainly in the field of dermatology using 5-aminolevulanic acid and in dentistry using phenothiazinium dyes. We expect more to see applications of PDT to more challenging infections using advanced antimicrobial photosensitizers targeted to microbial cells in the years to come.

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Section: Pdt Of Viral Lesionsmentioning

confidence: 59%

Photodynamic therapy for infections: Clinical applications

et al. 2011

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“…Compared to the global or European average, a higher HPV prevalence was detected in previous Lithuanian studies: HPV in cervical cancer patients was detected in 92.0% and in 23.6% of healthy women [13,14]. In Belarusian studies HPV prevalence was stated in 78.6% of women with CIN2-3 [15] and in 27.5% of healthy women with various risk factors [16]. So, both countries show a high level of HPV infection in the healthy population in comparison with European average.…”

Section: Discussionmentioning

confidence: 86%

Differences on the prevalence of cervical HPV between Lithuania and Belarus

et al. 2014

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AbstractIn some countries the cervical cancer incidence and mortality rates are much higher compared to the European average. The differences of HPV and its type prevalence between countries and regions influence cervical cancer incidence and mortality. Regarding the differences in cervical cancer incidence and mortality in Lithuania and Belarus, the aim of this study was to describe HPV infection level and HPVs type distribution among two study groups of patients with moderate or severe cervical intraepithelial neoplasia (CIN2-3) and cervical cancer. Our data shows that 74.2% [95% CI: 63.64÷84.76] of Lithuanian patients with cervical cancer and 85.6% [95% CI: 85.53÷92.85] of the study group with CIN2-3 were HPV positive, while in the study groups of Belarusian patients HPV infection was detected in 92.6% [95% CI, 74.25÷98.71] and 65.4% [95% CI, 44.36÷82.06] cases respectively. HPV 16 was the most prevalent type in Lithuanian as well as in Belarusian patients of the study groups. HPV 18 in Lithuanian patients of the study group with cervical cancer was identified in 10.2% [95% CI: 1.73÷18.67] and in the study group with CIN2-3 — in 2.6% [95% CI: 0.95÷6.15] of cases. HPV 18 was not detected in Belarusian patients of both groups.

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“…Each of these dysplasias is considered a precursor to invasive carcinoma, and a nondisfiguring therapy to prevent cancer progression would be valuable. For cervical intraepithelial neoplasia (CIN), PDT offers a nonscarring alternative to cone biopsy, as described in a case series of 112 patients whose CIN was treated using PDT with chlorin e6 (Fotolon), with 92% clearance [60]. In another study of 25 patients with CIN treated with hexyl-ALA PDT, complete response and fibrosis-free healing was confirmed histologically [61].…”

Section: Pdt For Genital and Perineal Cancers (Mucosal Intraepithementioning

confidence: 99%

Biomodulatory approaches to photodynamic therapy for solid tumors

Anand¹,

Ortel²,

Pereira³

et al. 2012

Cancer Letters

148

153

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Photodynamic Therapy (PDT) uses a photosensitizing drug in combination with visible light to kill cancer cells. PDT has an advantage over surgery or ionizing radiation because PDT can eliminate tumors without causing fibrosis or scarring. Disadvantages include the dual need for drug and light, and a generally lower efficacy for PDT versus surgery. This minireview describes basic principles of PDT, photosensitizers available, and aspects of tumor biology that may provide further opportunities for treatment optimization. An emerging biomodulatory approach, using methotrexate or Vitamin D in combination with aminolevulinate-based PDT, is described. Finally, current clinical uses of PDT for solid malignancies are reviewed.

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Photodynamic therapy of cervical intraepithelial neoplasia grades II and III with Photolon®

Cited by 61 publications

References 14 publications

Photodynamic therapy for infections: Clinical applications

Photodynamic therapy for infections: Clinical applications

Differences on the prevalence of cervical HPV between Lithuania and Belarus

Biomodulatory approaches to photodynamic therapy for solid tumors

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