Photodynamic therapy of oral lichen planus

Hesse, Juliane; Schmalfuss, Andreas

doi:10.1039/d0pp00249f

Cited by 14 publications

(21 citation statements)

References 44 publications

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“…In addition to our own study, comparative and methodologically correct assessments by other authors [29,30,32], systematic reviews of the literature [18,20,40] and a metaanalysis [21] provide the basis for sanctioning photodynamic therapy as a second-line method in the treatment of OLP. In situations of topical or general contraindications to oral corticosteroids, resistance to them, or the need for repeated treatment in a short period of time, it appears to be a very promising treatment option.…”

Section: Discussionmentioning

confidence: 86%

“…Assessment of the analgesic effect is inherent in any study of the efficacy of OLP treatment and the most commonly used index for this purpose is the visual-analogue scale and its modifications [14,18,40]. The ongoing bilateral topical treatment among our patients resulted in a significant reduction in pain intensity especially immediately after the therapy.…”

Section: Discussionmentioning

confidence: 94%

“…This may be a form of phototoxic inflammation associated with histamine release [45]. Despite these possible complications, PDT in the treatment of lichen is considered a safe method [18,20,21,40], which can be an alternative to topical corticosteroid therapy also due to its many topical and general side effects.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical trials for the use of photodynamic therapy in OLP have been ongoing since 2006 [17]. This treatment involves the penetration of a photosensitiser into overproliferating inflammatory cells, including T cells (CD4 + , CD8 + , Th17), in the subepithelial connective tissue, followed by their selective apoptosis under the influence of oxygen free radicals formed after light beam emission, followed by epithelial healing with regeneration [18]. In addition, following PDT of oral lichen lesions, significant reductions in IL-17a + , CD4 + CD137 + , CD8 + CD137 + T-cell counts, and CLXCL10 chemokine were observed in peripheral blood one month after treatment, also indicating a systemic anti-inflammatory effect [19].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, following PDT of oral lichen lesions, significant reductions in IL-17a + , CD4 + CD137 + , CD8 + CD137 + T-cell counts, and CLXCL10 chemokine were observed in peripheral blood one month after treatment, also indicating a systemic anti-inflammatory effect [19]. To date, the results of studies comparing PDT with topical corticosteroid therapy in OLP in terms of pain reduction, reduction in lesion area and desired evolution of inflammatory lesions are divergent [18][19][20], as are the conclusions of two meta-analytical comparisons of PDT efficacy in this clinical application [16,21]. Limitations to the use of PDT in OLP are the disparate clinical management protocols, the variety of photosensitisers used, and the difficulty of maintaining them in the oral environment.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

A Comparison of Clinical Efficiency of Photodynamic Therapy and Topical Corticosteroid in Treatment of Oral Lichen Planus: A Split-Mouth Randomised Controlled Study

Zborowski

Kida

Szarwaryn

et al. 2021

JCM

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Background: The aim of the study was to compare the effectiveness of photodynamic therapy (PDT) to steroid therapy in the treatment of oral lichen planus (OLP). Due to the lack of commercially available drug carriers, innovative proprietary solutions were used for both the photosensitiser and the steroid carrier—in the first case to shorten and in the second to extend the contact of the active substance with the mucosa. Methods: A prospective, randomised, single-blind, 12-week full contralateral split-mouth clinical trial of 30 patients with bilateral oral lichen planus was conducted. The prepared matrices were incorporated with active substances methylene blue 5% and 0,05% triamcinolone. The size of lesions, Thongprasom, ABISIS, and VAS scale were evaluated. Results: Relatively high rates of complete remission of lichen were demonstrated: immediately after treatment, 33.3% with PDT and 22.2% with triamcinolone (TA), and after 3 months, 54.2% with PDT and 62.9% with TA. After 3 months of treatment, a reduction in the area of evaluated lesions of 52.7% for PDT and 41.7% for TA was achieved. Conclusion: In situations of topical or general contraindications to oral corticosteroids, resistance to them, or the need for repeated treatment in a short period of time, PDT appears to be a very promising treatment option.

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