Photodynamic therapy on skin melanoma and epidermoid carcinoma cells using conjugated 5-aminolevulinic acid with microbial synthesised silver nanoparticles

Shivashankarappa, Aishwarya; Sanjay, Konasur Rajesh

doi:10.1080/1061186x.2018.1531418

Cited by 19 publications

(6 citation statements)

References 16 publications

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“…We ranked the pathways based on the

( Yue et al, 2019a ). As reported the highest PubMed score in Table 2 , the photodynamic therapy has been frequently reported for melanoma treatment in recent years ( Shivashankarappa and Sanjay, 2019 ; Turkoglu et al, 2019 ; Abramova et al, 2021 ; Yordi et al, 2021 ). We observed that in the overlapped genes between differentially expressed gene candidates and the photodynamic therapy-induced ap-1 survival signaling’s gene members, the five genes, IL6 (Interleukin 6), CDKN1A (Cyclin Dependent Kinase Inhibitor 1A), FGF7 (Fibroblast Growth Factor 7), BCL3 (B-Cell Lymphoma 3-Encoded Protein) and PDGFRA (Platelet Derived Growth Factor Receptor Alpha) were under-expressed in the drug-resistant patients, and the three genes, IL6, CDKN1A and FGF7 were connected in the gene regulatory network from PAGER ( de Waal Malefyt et al, 1991 ) ( Figure 4 ).…”

Section: Resultsmentioning

confidence: 99%

PAGER Web APP: An Interactive, Online Gene Set and Network Interpretation Tool for Functional Genomics

et al. 2022

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Functional genomics studies have helped researchers annotate differentially expressed gene lists, extract gene expression signatures, and identify biological pathways from omics profiling experiments conducted on biological samples. The current geneset, network, and pathway analysis (GNPA) web servers, e.g., DAVID, EnrichR, WebGestaltR, or PAGER, do not allow automated integrative functional genomic downstream analysis. In this study, we developed a new web-based interactive application, “PAGER Web APP”, which supports online R scripting of integrative GNPA. In a case study of melanoma drug resistance, we showed that the new PAGER Web APP enabled us to discover highly relevant pathways and network modules, leading to novel biological insights. We also compared PAGER Web APP’s pathway analysis results retrieved among PAGER, EnrichR, and WebGestaltR to show its advantages in integrative GNPA. The interactive online web APP is publicly accessible from the link, https://aimed-lab.shinyapps.io/PAGERwebapp/.

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“…We ranked the pathways based on the

Section: Resultsmentioning

confidence: 99%

PAGER Web APP: An Interactive, Online Gene Set and Network Interpretation Tool for Functional Genomics

et al. 2022

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“…T-test studies on the cell lines showed better inhibition of conjugated NPs than the pure NPs. [81] AgNPs functionalized with Formazan showed higher cytotoxicity than those with pure AgNPs. This is due to the significant enhancement in the absorption intensities of the dyes and the shift in their absorption bands inside the therapeutic window.…”

Section: Silver Nanoparticlesmentioning

confidence: 90%

“…T‐test of AgNPs and positive control of NPs functionalized with the drug showed better cytotoxicity. T‐test studies on the cell lines showed better inhibition of conjugated NPs than the pure NPs [81] . AgNPs functionalized with Formazan showed higher cytotoxicity than those with pure AgNPs.…”

Section: Types Of Nanoparticlesmentioning

confidence: 94%

Photosensitizer Anchored Nanoparticles: A Potential Material for Photodynamic Therapy

et al. 2022

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Detection and treatment of cancer have been demanding areas with the increase in cancer and malignant diseases across the globe. Photodynamic therapy is a multi‐step treatment procedure using photosensitizers as a drug in the presence of light. Photosensitizers anchored on different nanomaterials through covalent and non‐covalent interactions contribute significantly to photodynamic therapy. Nanoparticles have been employed as promising carriers to transport photosensitizers to the target cells. Photosensitizer functionalized nanoparticles are more effective in terms of stability and water solubility than bare ones. This review is a brief account of different types of nanoparticles functionalized on photosensitizers currently used for photodynamic therapy. We have focused on photosensitizer anchored organic, inorganic, and carbon‐based nanomaterials, which can be effectively used in photodynamic therapy.

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“…Ag Nanoparticles (AgNPs). Shivashankarappa and Sanjay [80] synthesized Ag NPs by the bacterial strain Bacillus licheniformis and used photodynamic therapy (PDT) of 5aminolevulinic acid (5-ALA) conjugated with synthesized Ag NPs (microbial) on epidermoid carcinoma (A431) and skin melanoma (B16F10) cell lines. The cytotoxicity of NPs coupled with 5-aminolevulinic acid and pure NPs was evaluated by polyethylene glycol (PEG) on cell lines (B16F10 and A431) and compared with the 5-aminolevulinic acid standard.…”

Section: Diagnosis Of Skin Cancermentioning

confidence: 99%

Applications of Metallic Nanoparticles in the Skin Cancer Treatment

Marzi

Osanloo

Vakil

et al. 2022

BioMed Research International

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Skin cancer is one of leading cancers globally, divided into two major categories including melanoma and nonmelanoma. Skin cancer is a global concern with an increasing trend, hence novel therapies are essential. The local treatment strategies play a key role in skin cancer therapy. Nanoparticles (NPs) exert potential applications in medicine with huge advantages and have the ability to overcome common chemotherapy problems. Recently, NPs have been used in nanomedicine as promising drug delivery systems. They can enhance the solubility of poorly water-soluble drugs, improve pharmacokinetic properties, modify bioavailability, and reduce drug metabolism. The high-efficient, nontoxic, low-cost, and specific cancer therapy is a promising goal, which can be achieved by the development of nanotechnology. Metallic NPs (MNPs) can act as important platforms. MNPs development seeks to enhance the therapeutic efficiency of medicines through site specificity, prevention of multidrug resistance, and effective delivery of therapeutic factors. MNPs are used as potential arms in the case of cancer recognition, such as Magnetic Resonance Imaging (MRI) and colloidal mediators for magnetic hyperthermia of cancer. The applications of MNPs in the cancer treatment studies are mostly due to their potential to carry a large dose of drug, resulting in a high concentration of anticancer drugs at the target site. Therefore, off-target toxicity and suffering side effects caused by high concentration of the drug in other parts of the body are avoided. MNPs have been applied as drug carriers for the of improvement of skin cancer treatment and drug delivery. The development of MNPs improves the results of many cancer treatments. Different types of NPs, such as inorganic and organic NPs have been investigated in vitro and in vivo for the skin cancer therapy. MNPs advantages mostly include biodegradability, electrostatic charge, good biocompatibility, high drug payload, and low toxicity. However, the use of controlled-release systems stimulated by electromagnetic waves, temperature, pH, and light improves the accumulation in tumor tissues and improves therapeutic outcomes. This study (2019-2022) is aimed at reviewing applications of MNPs in the skin cancer therapy.

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Photodynamic therapy on skin melanoma and epidermoid carcinoma cells using conjugated 5-aminolevulinic acid with microbial synthesised silver nanoparticles

Cited by 19 publications

References 16 publications

PAGER Web APP: An Interactive, Online Gene Set and Network Interpretation Tool for Functional Genomics

PAGER Web APP: An Interactive, Online Gene Set and Network Interpretation Tool for Functional Genomics

Photosensitizer Anchored Nanoparticles: A Potential Material for Photodynamic Therapy

Applications of Metallic Nanoparticles in the Skin Cancer Treatment

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