Photodynamic therapy: unapproved uses, dosages, or indications

Salva, Katrin A.

doi:10.1016/s0738-081x(02)00266-3

Cited by 56 publications

(47 citation statements)

References 105 publications

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“…The X-band EPR spectra were recorded in situ using a field-modulated CW Towers, 1991), as well as for naturally occurring quinones (Alegría et al, 1999;Inbaraj et al, 1999) and other substances (Arnason et al, 1992;Wu et al, 2000). The photoproduced oxygen reactive species ( · OH, O 2 · − , 1 O 2 ) play a specific and important role in cell damage in photodynamic therapy (Henderson and Dougherty, 1992;Salva, 2002;Vrouenraets et al, 2003;Dolmans et al, 2003). On the other hand, the medical application of photoactive therapeutic compounds could bring undesired side-reactions in treated patients (Filipe et al, 1997;Krutmann, 2000), or technical problems during drug applications (Dodds et al, 1997;Dodds et al, 1998;Li et al, 2001).…”

Section: Methodsmentioning

confidence: 99%

Oxygen activation by photoexcited protoberberinium alkaloids from Mahonia aquifolium

Brezová¹,

Dvoranová²,

Kostálová³

2004

Phytotherapy Research

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Protoberberinium salts, i.e. berberine (I), palmatine (II) and jatrorrhizine (III) prepared from Mahonia aquifolium (Pursh) Nutt. belong to isoquinoline alkaloids possessing interesting biological activity (e.g. antibacterial, antimalarial, antitumor). The characteristic UV/Vis absorption band maxima of I-III iodide salts were found in regions 350 and 425 nm in dimethylsulfoxide (DMSO) and ethanol solvents, and were only negligibly influenced by substitution changes on the C-2 and C-3 positions. The fluorescence intensity of protoberberinium salts monitored in ethanol solutions was significantly lowered by iodide counter-ions, and decreased in the order berberine > palmatine > jatrorrhizine. EPR spectroscopy supplied evidence of the formation of super-oxide anion radicals and singlet oxygen upon irradiation of berberine in oxygenated DMSO solvent. The photochemical generation of O(2) (.-) and (1)O(2) in DMSO solutions of palmatine and jatrorrhizine was substantially lower, and probably reflected the replacement of a photolabile methylenedioxy group at C-2 and C-3 positions in the berberine molecule by two methoxy groups in palmatine, and methoxyl (C-2) and hydroxyl (C-3) substitution in jatrorrhizine. Additionally, the powder EPR spectra of protoberberinium iodides I-III measured at 290 K revealed the presence of single-line EPR signals (g(eff) = 2.0044), which were attributed to hydroperoxidic structures produced by the autoxidation process. The photochemical reactions of protoberbenium salts producing reactive oxygen species after UVA excitation should be integrated in biological activity investigations, as well as in their applications in skin disorder treatment.

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Section: Methodsmentioning

confidence: 99%

Oxygen activation by photoexcited protoberberinium alkaloids from Mahonia aquifolium

Brezová¹,

Dvoranová²,

Kostálová³

2004

Phytotherapy Research

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“…The light source for PAD can be divided into three main categories namely: (1) broad spectrum lamps, (2) Light emitting diode lamps (LED) and 3) lasers. 80 Among the different sources, lasers show some advantages like monochromacy which allows the laser to best interact with PS due to matching precisely with its peak absorption, which reduces unnecessary tissue heating by bandwidths not effective in PDT reaction. 81 In dentistry, most of the PS are activated by the red light wave lengths between 630-700 nm.…”

Section: Lightmentioning

confidence: 99%

Clinical Approach of High Technology Techniques for Control and Elimination of Endodontic Microbiota

et al. 2015

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The main goal in endodontic treatment is to eradicate or at least reduce intraradicular microbial population to levels that are more compatible with periapical lesions healing process. Since endodontic infections are polymicrobial in nature, intraradicular survival of endodontic microbiota and their pathogenic properties are influenced by a combination of their virulence factors. The purpose of this article is to review the endodontic microbiota and their respective virulence attributes, as well as perform a literature review of the effects of disinfection procedures in the treatment of endodontic infections to gain best practices. Conventional technique for root canal preparation includes mechanical debridement and application of antimicrobial irrigants. Recently, laser irradiation has been used to enhance the results of root canal treatment through its thermal effect. To reduce thermal side effects, laser activated irrigation (LAI) and photon induced photoacoustic streaming (PIPS) were introduced. Antimicrobial photodynamic therapy (aPDT) by photochemical reaction uses light at a specific wavelength to activate a nontoxic photosensitizer (PS) in the presence of oxygen to produce cytotoxic products. Different PSs are used in dentistry including methylene blue (MB), toluidine blue O (TBO), indocyanine green (ICG) and curcumin. Among different options, ICG could be the best choice due to its peak absorption at wavelength of 808 nm, which coincides with the commercial diode laser devices. Also, this wavelength has more penetration depth compared to other wavelengths used in aPDT.

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“…First, it is possible to use a single molecule for both purposes, since most porphyrin-like compounds can both emit fluorescence *Address correspondence to this author at the Ontario Cancer Institute/University of Toronto, MaRS Center, 101 College Street, Toronto, ON M5G 1L7, Canada; Tel: +1-416-581-7666; Fax: +1-416-581-7667; E-mail: gang.zheng@uhnres.utoronto.ca (for NIRF-I) and produce cytotoxic reactive oxygen species (for PDT) when activated by light [5,6]. Second, the concentrations required for killing and imaging cells are in the same range and third, both of the techniques are promising in vivo cancer imaging and treatment modalities [7,8].…”

Section: Combined Cancer Imaging and Therapymentioning

confidence: 99%

Killer Beacons for Combined Cancer Imaging and Therapy

Stefflova¹,

Chen²,

Zheng

2007

CMC

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Cu r r e n t Me d i c i n a l Ch e mi s t r y c o v e r s a l l t h e l a t e s t a n d o u t s t a n d i n g d e v e l o p me n t s i n me d i c i n a l c h e mi s t r y a n d r a t i o n a l d r u g d e s i g n . E a c h i s s u e c o n t a i n s a s e r i e s o f t i me l y i n -d e p t h r e v i e w s a n d g u e s t e d i t e d t h e ma t i c i s s u e s w r i t t e n b y l e a d e r s i n t h e f i e l d c o v e r i n g a r a n g e o f t h e c u r r e n t t o p i c s i n i n me d i c i n a l c h e mi s t r y . Cu r r e n t Me d i c i n a l Ch e mi s t r y i s a n e s s e n t i a l j o u r n a l f o r e v e r y me d i c i n a l c h e mi s t w h o w i s h e s t o b e k e p t i n f o r me d a n d u p -t o -d a t e w i t h t h e l a t e s t a n d mo s t i mp o r t a n t d e v e l o p me n t s .

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Photodynamic therapy: unapproved uses, dosages, or indications

Cited by 56 publications

References 105 publications

Oxygen activation by photoexcited protoberberinium alkaloids from Mahonia aquifolium

Oxygen activation by photoexcited protoberberinium alkaloids from Mahonia aquifolium

Clinical Approach of High Technology Techniques for Control and Elimination of Endodontic Microbiota

Killer Beacons for Combined Cancer Imaging and Therapy

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