Photodynamic therapy with methyl aminolaevulinate 80 mg g<sup>−1</sup>for severe facial acne vulgaris: a randomized vehicle-controlled study

Pariser, D M; Eichenfield, Lawrence F.; Bukhalo, Michael; Waterman, Gabriel N.; Jarratt, Michael

doi:10.1111/bjd.14345

Cited by 36 publications

(39 citation statements)

References 22 publications

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“…The clinical aspect of the reaction was similar to a hypertrophic AK associated with an infective affection. Considering the well-known utility of ALA-PDT in the doi: 10.18282/jsd.v1.i1.36 treatment of both AK and infective diseases, we applied it on the patient's skin in order to solve the severe local reaction [5] . We observed a complete resolution just after two sessions of PDT.…”

Section: Resultsmentioning

confidence: 99%

Severe local skin reaction after the application of ingenol mebutate gel treated by photodynamic therapy: A case report

et al. 2016

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Ingenol mebutate (IM) was recently introduced for the treatment of actinic keratosis (AK). It is considered a safe and effective treatment in spite of local reactions frequently reported. These reactions may consist of erythema, flaking, crusting, swelling, vesicles and erosions, and would usually spontaneously recede within 20-30 days. We reported a case of a patient affected by multiple actinic keratosis of the scalp treated with IM. The patient reported a severe reaction that was not solved in two months. We decided to treat the reaction with photodynamic therapy and aminolevulinic acid. This treatment was demonstrated to be effective in solving this severe side effect.

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Section: Resultsmentioning

confidence: 99%

Severe local skin reaction after the application of ingenol mebutate gel treated by photodynamic therapy: A case report

et al. 2016

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“…These ROS then cause sebaceous gland damage and destruction of P. acnes . MAL, which is a commonly used photosensitizer outside of the US, has also been used in PDT for acne treatment and has demonstrated significant efficacy in decreasing ILC [146]. PDT shows great promise in treating acne ranging from mild to severe, but the optimal choice of photosensitizer and light source are topics still under investigation [19].…”

Section: Discussionmentioning

confidence: 99%

Optimizing Non-Antibiotic Treatments for Patients with Acne: A Review

Canavan

Chen

Elewski

2016

Dermatol Ther (Heidelb)

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Acne is a very common non-infectious skin condition that is frequently treated in dermatological practices. Because acne is often chronic and may persist for years, safe and effective long-term maintenance therapy is often required. Given the increasing frequency of antibiotic-resistant bacteria and the gravity of the consequences of this trend, it behooves dermatologists to maximize use of non-antimicrobial therapy when treating acne. In this review of the literature we present data regarding the efficacy and appropriate use of non-antimicrobial treatments for acne. A variety of topical and oral treatment options exist that can be used in a step-wise manner according to the patients’ severity and therapeutic response. Non-antimicrobial treatments can be highly efficacious at controlling acne, especially when used as maintenance therapy. While antibiotics have a role in acne treatment, they should not be used as monotherapy, and lengthy courses of antibiotic use are discouraged.

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“…Pariser et al . conducted a double‐blind, randomized, vehicle‐controlled multicenter trial in 153 patients (age range 12–36 years; median 17) with MAL‐PDT. Fifty‐nine of those treated were children.…”

Section: Methodsmentioning

confidence: 99%

Photodynamic therapy for dermatologic conditions in the pediatric population: a literature review

Kumar

Warren

2017

Photoderm Photoimm Photomed

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Summary Photodynamic therapy (PDT), using topical aminolevulinic acid (ALA), has been used for years to treat a variety of dermatologic conditions, including actinic keratosis, superficial basal cell carcinoma, and in situ squamous cell carcinoma. While there is a wide range of neoplastic and non‐neoplastic skin diseases for which ALA‐PDT is used in adults, there is a knowledge gap when it comes to its use in children. This review highlights what is currently known regarding the use and efficacy of this therapy in the pediatric population. A PubMed search was conducted to identify studies including pediatric patients undergoing monotherapy PDT with topical aminolevulinate (published 2005–2016). Twenty pediatric articles were identified. ALA‐PDT has been used successfully in children to reduce the number and size of basal cell tumors, inflammatory acne lesions, plantar warts, and linear porokeratoses. ALA‐PDT may be an attractive alternative to surgery for children with basal cell nevus syndrome, or to conventional destructive and/or topical methods used for plantar warts or linear porokeratoses. PDT can be considered for inflammatory acne when topical treatments have failed and systemic medications are not an option. Pain associated with treatment and insurance coverage may be a barrier to use.

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Photodynamic therapy with methyl aminolaevulinate 80 mg g⁻¹for severe facial acne vulgaris: a randomized vehicle-controlled study

Abstract: PDT using topical MAL 80 mg g(-1) and red light may offer promise for severe acne vulgaris.

Cited by 36 publications

References 22 publications

Severe local skin reaction after the application of ingenol mebutate gel treated by photodynamic therapy: A case report

Severe local skin reaction after the application of ingenol mebutate gel treated by photodynamic therapy: A case report

Optimizing Non-Antibiotic Treatments for Patients with Acne: A Review

Photodynamic therapy for dermatologic conditions in the pediatric population: a literature review

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Photodynamic therapy with methyl aminolaevulinate 80 mg g−1for severe facial acne vulgaris: a randomized vehicle-controlled study

Abstract: PDT using topical MAL 80 mg g(-1) and red light may offer promise for severe acne vulgaris.

Cited by 36 publications

References 22 publications

Severe local skin reaction after the application of ingenol mebutate gel treated by photodynamic therapy: A case report

Severe local skin reaction after the application of ingenol mebutate gel treated by photodynamic therapy: A case report

Optimizing Non-Antibiotic Treatments for Patients with Acne: A Review

Photodynamic therapy for dermatologic conditions in the pediatric population: a literature review

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Product

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Photodynamic therapy with methyl aminolaevulinate 80 mg g⁻¹for severe facial acne vulgaris: a randomized vehicle-controlled study