Photodynamic Toxicity of Chlorophyllin against Fasciola gigantica Carrier Snail Indoplanorbis exustus in Visible Spectral Band

Chaturvedi, Divya; Singh, Dinesh; Singh, Vinay Kumar

doi:10.5530/pj.2017.6.115

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…Juice from fresh leaves of S. oleracea is used. [17][18][19][20][21][22][23] There are a significant number of spinach cultivars, some of them were carefully investigated. In the work 24 a study of the polyphenols content in S. oleracea "Marquise" cultivar was carried out.…”

Section: Methods Of Functional Extracts Formulation From S Oleracea mentioning

confidence: 99%

Prospects for the Use of Spinach (Spinacia oleracea L.) Containing Phytoecdysteroids and Polyphenols

YuS¹,

Vk²,

Vv³

2020

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Background: Phytoadaptogens, biologically active compounds increasing the nonspecific resistance of the human organism, are well known for the prevention and correction of stressful conditions. Phytoadaptogens group includes phytoecdysteroids and polyphenols, that are characterized by the multiplicity of pharmacological effects in combination with the low toxicity. According to literature data, spinach (Spinacia oleracea L.) is a promising source of these compounds. This work aims to systematize data on the chemical composition of biologically active compounds of spinach, that determine its adaptogenic properties and concentration methods in the spinach processing for use in specialized foods and dietary supplements. Materials and Methods: Manifold electronic search engines, electronic databases, and libraries such as Google, Google scholar, Crossref, Indian Science Abstracts, Emerging Sources Citation Index, e-Library, Scopus, Web of Science, Pubmed, Chemical Abstracts, Index Copernicus, scientific literature had been searched and data obtained. Results: Botanical characteristics of spinach, main cultivation conditions, the latest data on the chemical composition of raw spinach material cultivars and extracts based on it are presented in this study. Schemes for the obtaining of products enriched with polyphenols and ecdysteroids are considered, and ways of proper purification are mentioned. Conclusion: It is recommended to introduce spinach into the diet of healthy people in order to increase the functional reserves of a person during periods of hypovitaminosis, overwork, intense physical exertion, and also to compensate for the adverse effects of external factors. Spinach extracts containing phytoecdysteroids (20-hydroxyecdysone) and polyphenols (flavonoids) can be used as a prophylactic to overcome the negative effects of stress, accelerate recovery after strong physical and mental stress, particularly for people with extreme occupations, athletes, and those who are engaged in hard physical labor.

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Section: Methods Of Functional Extracts Formulation From S Oleracea mentioning

confidence: 99%

Prospects for the Use of Spinach (Spinacia oleracea L.) Containing Phytoecdysteroids and Polyphenols

YuS¹,

Vk²,

Vv³

2020

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“…Chlorophyll is the most abundant natural pigment and has been considered as hypoglycemic agent via mechanism of free radicals' inhibition [ 6 ]. Chlorophyllin is a semisynthetic substance that is created by replacing the chlorophyll magnesium ion with another metal and removing the phytol tail [ 7 ]. Recent studies have shown that both chlorophyllin and metformin (a medication for diabetes) inhibit gluconeogenesis and increase glucose uptake by peripheral muscles [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Antihyperglycemic Effect of Crude Liang (Gnetum gnemon var. tenerum) Leaves Powder on Wistar Rats

Suksanga,

Siripongvutikorn,

Leelawattana

et al. 2023

Journal of Nutrition and Metabolism

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Chlorophyll and chlorophyllin (CHL) demonstrated antidiabetic activity by inhibiting gluconeogenesis and increasing glucose uptake in rats’ muscle cells. Liang leaves contain high amounts of chlorophyll and chlorophyllin and may provide an antidiabetic effect. The antidiabetic activity of chlorophyll and CHL contained in Liang leaves, Cu-chlorophyllin (CCL) Liang leaves treated with CuSO4, and untreated crude Liang leaves (CLL) were compared using commercial chlorophyllin (CHL) as a reference. Twelve Wistar male rats were separated into 4 groups (3 rats/group); the first was a normal one (based line group), the second were the diabetic rats treated with CHL, while the third and the fourth were the diabetic rats treated with 0.97 g/kg of CCL and CLL, respectively. Diabetic rats were induced by a high fructose diet, before being taken to administer commercial CHL, CCL, and CLL for 7 days. Nonfasting blood glucose and body weight were checked daily. After euthanasia, organ weight, biochemical, hematological, and histopathological properties were evaluated. CCL treatment showed no antihyperglycemic activity in the rat model but caused some biochemical abnormalities and thrombocytopenia. Commercial CHL gave a higher reduction of nonfasting blood glucose (NFBG) than Liang leaves powder CCL or CLL but also showed some signs of abnormal biochemical parameters. CLL exhibited an antihyperglycemic effect, with higher body weight and increased HDL/LDL ratio and thus could be a promising alternative natural source for diabetes treatment.

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“…CHLIN is distinguished by an intense Q-band at 630 nm [15], which is an ideal characteristic for use in photodynamic therapy (PDT), a technique applied in the case of cancer treatments and damaging diseased living tissue treatments with visible light in the presence of photosensitizers and O 2 [16,17]. The most common chlorophylls used in PDT are chlorine e 6 and other synthetic chlorines [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Investigations of commercial sodium copper chlorophyllin degradation after ultraviolet irradiation

Petrović,

Savić,

Zvezdanović

et al. 2023

Adv Techol

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Chlorophyllins are naturally derived colors that provide green hues to food products in oil- and water-based systems. Due to their good antimicrobial activity, in order not to contaminate the surface of food products and to increase product expiration dates and safety, the use of commercial chlorophyllin is common in the form of antimicrobial films that could cover fresh or processed food. UV irradiation effects on commercial sodium copper chlorophyllin are examined to estimate the potential application risk of this chlorophyll derivative for use in foods and cosmetics. Photodegradation of an aqueous 1 × 10-4 M commercial sodium copper chlorophyllin solution was monitored after ultraviolet irradiation. The samples were irradiated for a period of 0 - 60 min. in a cylindrical photochemical reactor called "Rayonnet" with symmetrically placed lamps that emit an energy flux of 12 W/m2 at 300 nm. Ultrahigh liquid chromatography coupled with a diode array and electrospray ionization mass spectrometry was used to monitor the loss of major components of sodium copper chlorophyllin after irradiation, as well as, to detect possible new products. It is estimated that the photodegradation of all detected compounds follows first-order kinetics. UHPLC analysis showed the loss of the major chlorophyllin component, copper chlorin e6 , at a rate faster than the overall detected components, in the range of 7.02 × 10-2 min-1.The observed photosensitivity of sodium copper chlorophyllin was lower than to the natural chlorophylls, and raising the possibility of its use in food and cosmetics. The main detected photoproducts are oxidized compounds of chlorophyllin. For all these reasons, the rapid loss of copper chlorin e6 , may reduce some of the main commercial sodium copper chlorophyllin dietary benefits, like antimutagenic and antioxidant activity.

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Photodynamic Toxicity of Chlorophyllin against Fasciola gigantica Carrier Snail Indoplanorbis exustus in Visible Spectral Band

Cited by 3 publications

References 26 publications

Prospects for the Use of Spinach (Spinacia oleracea L.) Containing Phytoecdysteroids and Polyphenols

Prospects for the Use of Spinach (Spinacia oleracea L.) Containing Phytoecdysteroids and Polyphenols

The Antihyperglycemic Effect of Crude Liang (Gnetum gnemon var. tenerum) Leaves Powder on Wistar Rats

Investigations of commercial sodium copper chlorophyllin degradation after ultraviolet irradiation

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