Photography of the retina in mice congenitally infected with<i>Toxoplasma gondii</i>

Dutton, Gordon N.; Hay, John; Hair, D. M.; Kerrigan, P

doi:10.1080/00034983.1984.11811843

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…During the experiments both eyes were examined using the procedures described previously (23). The method of DUTTON et al (5) was used to examine the posterior segment of eyes.…”

Section: Methodsmentioning

confidence: 99%

Spread of herpes simplex virus and distribution of latent infection after intraocular infection of the mouse

Shimeld

Tullo

Hill

et al. 1985

Archives of Virology

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Intraocular inoculation of HSV 1 in the mouse results not only in uveitis, but also in the spread of virus via sensory, sympathetic and optic nerves. During the acute infection with HSV 1 strain SC 16 in both outbred and NIH (inbred) mice, virus reached the ipsilateral trigeminal ganglion, superior cervical ganglion, both sides of the brain stem and the contralateral (uninoculated) eye. With HSV 1 strain KOS in outbred mice the same tissues became infected but virus was also isolated from the ophthalmic part of the contralateral trigeminal ganglion. After resolution of the acute disease in outbred mice, latent infection with strain KOS was demonstrated in both trigeminal ganglia and in the ipsilateral superior cervical ganglion. With strain KOS, virus was sometimes isolated from eyes removed more than a month after inoculation and then cultured in vitro for 2-3 weeks. By electron microscopy infected cells were seen in the choroid and sclera of such eyes.

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“…During the experiments both eyes were examined using the procedures described previously (23). The method of DUTTON et al (5) was used to examine the posterior segment of eyes.…”

Section: Methodsmentioning

confidence: 99%

Spread of herpes simplex virus and distribution of latent infection after intraocular infection of the mouse

Shimeld

Tullo

Hill

et al. 1985

Archives of Virology

View full text Add to dashboard Cite

show abstract

Clinicopathological features of a congenital murine model of ocular toxoplasmosis

Dutton

Hay

Hair

et al. 1986

Graefe's Arch Clin Exp Ophthalmol

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Sequential clinical examination was carried out upon the eyes of mice that had been infected in utero with Toxoplasma gondii. Three patterns of clinical disease were seen. First, crystalliform cataracts, which either remained unchanged in character or occasionally became more extensive, were observed. Second, acute uveitis occurred in a small proportion of eyes, progressing into a chronic inflammatory disease with secondary opaque cataract. The third pattern comprised multiple discrete foci of deep retinal disturbance. It is suggested that these lesions were attributable to focal macrophage clusters in the sub-retinal space with overlying dome-shaped elevations of the photoreceptor matrix. The severity of disease, as assessed clinically, correlated with the underlying histopathology but not with the serological titres against Toxoplasma. Immunocytochemical staining for Toxoplasma antigen revealed only intra-retinal Toxoplasma cysts, but no free organisms or extracystic antigen were demonstrated. Selective photoreceptor destruction was the most prominent histopathological feature, implicating auto-immune mechanisms of tissue destruction.

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The ultrastructural pathology of congenital murine toxoplasmic retinochoroiditis. Part I: the localization and morphology of Toxoplasma cysts in the retina

McMenamin

Dutton

Hay

et al. 1986

Experimental Eye Research

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Photography of the retina in mice congenitally infected withToxoplasma gondii

Cited by 4 publications

References 4 publications

Spread of herpes simplex virus and distribution of latent infection after intraocular infection of the mouse

Spread of herpes simplex virus and distribution of latent infection after intraocular infection of the mouse

Clinicopathological features of a congenital murine model of ocular toxoplasmosis

The ultrastructural pathology of congenital murine toxoplasmic retinochoroiditis. Part I: the localization and morphology of Toxoplasma cysts in the retina

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