2021
DOI: 10.3390/gels7030124
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Photoinduced Porcine Gelatin Cross-Linking by Homobi- and Homotrifunctional Tetrazoles

Abstract: Gelatin is a costless polypeptide material of natural origin, able to form hydrogels that are potentially useful in biomaterial scaffold design for drug delivery, cell cultures, and tissue engineering. However, gelatin hydrogels are unstable at physiological conditions, losing their features only after a few minutes at 37 °C. Accordingly, treatments to address this issue are of great interest. In the present work, we propose for the first time the use of bi- and trifunctional tetrazoles, most of them unknown t… Show more

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Cited by 6 publications
(7 citation statements)
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“…The Department of Biotechnology and Biosciences (Milan University) and the Milan-Bicocca University have functionalized the gelatin polymer to improve mechanical stability at physiological temperatures. Cross-linked gelatin has been generated by homobifunctional triazolinediones [ 43 ], and homobi- and homotri-functional tetrazoles in order to obtain more stable hydrogels [ 44 ]. Instead, the Polytechnic of Milan studied pectin hydrogel for tissue engineering applications.…”
Section: Polymers Overviewmentioning
confidence: 99%
See 1 more Smart Citation
“…The Department of Biotechnology and Biosciences (Milan University) and the Milan-Bicocca University have functionalized the gelatin polymer to improve mechanical stability at physiological temperatures. Cross-linked gelatin has been generated by homobifunctional triazolinediones [ 43 ], and homobi- and homotri-functional tetrazoles in order to obtain more stable hydrogels [ 44 ]. Instead, the Polytechnic of Milan studied pectin hydrogel for tissue engineering applications.…”
Section: Polymers Overviewmentioning
confidence: 99%
“… Materials Characteristics Applications Ref. Alginate Micro-structured hydrogel Bioprintable Accelerate wound closure Drug delivery Cancer model (neuroblastoma) Wound healing [ 1 , 2 , 9 , 12 ] Chitosan Chitin derivative Bioprintable Soft tissue engineering Mechano-responsive biomaterial Wound healing [ 3 , 4 , 13 , 14 , 21 , 22 , 23 ] dECM hydrogels Contains growth and differentiative factors Myogenic potential Organoid culture Skeletal muscle tissue engineering [ 37 , 38 , 39 , 40 ] Gelatin Collagen derivative Mechanically stable Drug delivery Cell culture Tissue engineering [ 43 , 44 ] Hyaluronic acid Component of connective tissue Injectable Cell culture Treatment of meniscal lesions Intervertebral disc regeneration Wound healing [ …”
Section: Polymers Overviewmentioning
confidence: 99%
“…Researchers have altered pH, temperature, and crosslinker to synthesize smaller GNPs. But these attempts thus far have generated GNPs larger than 100 nm, and particles smaller than that have not been obtained [ [25] , [26] , [27] ]. In an interesting study, researchers tried to shrink GNPs to 100 nm using a freeze-thaw method [ 28 ].…”
Section: Introductionmentioning
confidence: 99%
“…Addition of molecular species able to covalently cross-link the elastomers at the right stage of the process could be the solution of the aforementioned problems. We were attracted by tetrazole moiety, that can be thermally activated to form a nitrilimine intermediate displaying high reactivity toward several functional groups ( Scheme 1 ) [ 14 , 15 , 16 , 17 , 18 ], including 3+2 cycloaddition to pyrazoline in presence of C-C double bonds, which are abundant in polymers used for tires. Moreover, with the same type of substituents, the less the double bond is substituted, the better the reactivity of the cycloaddition [ 19 , 20 , 21 , 22 ], assuming a selectivity toward the vinyl bonds of elastomers.…”
Section: Introductionmentioning
confidence: 99%