Photon Correlation Spectroscopy – Extending the limits of                    concentration –

Willemse, A.W.; Nijman, E.J.; Marijnissen, J.C.M.; Merkus, Henk G.; Scarlett, B. Florence

doi:10.14356/kona.1998013

Cited by 3 publications

(1 citation statement)

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“…Modelling, prediction and process control in such batch systems is difficult and demands more and more sophisticated direct numerical simulation and computational fluid dynamic approaches [2±4]. Also state of the art on-line particle monitoring with non-evasive techniques with sub-particle resolution are needed to help model and monitor these tankstyle reactors [5].…”

Section: Introductionmentioning

confidence: 99%

Development of a Continuous Segmented Flow Tubular Reactor and the “Scale‐out” Concept – In Search of Perfect Powders

Jongen¹,

et al. 2003

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The synthesis of powders with controlled shape and narrow particle size distributions is still a major challenge for many industries. A continuous Segmented Flow Tubular Reactor (SFTR) has been developed to overcome homogeneity and scale‐up problems encountered when using batch reactors. Supersaturation is created by mixing the co‐reactants in a micromixer inducing precipitation; the suspension is then segmented into identical micro‐volumes by a non‐miscible fluid and sent through a tube. These micro‐volumes are more homogeneous when compared to large batch reactors leading to narrower size distributions, better particle morphology, polymorph selectivity and stoichiometry. All these features have been demonstrated on single tube SFTR for different chemical systems. To increase productivity for commercial application the SFTR is being “scaled‐out” by multiplying the number of tubes running in parallel instead of scaling‐up by increasing their size. The versatility of the multi‐tube unit will allow changes in type of precipitate with a minimum of new investment as new chemistry can be researched, developed and optimised in a single tube SFTR and then transferred to the multi‐tube unit for powder production.

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Section: Introductionmentioning

confidence: 99%

Development of a Continuous Segmented Flow Tubular Reactor and the “Scale‐out” Concept – In Search of Perfect Powders

Jongen¹,

et al. 2003

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Dynamic Light Scattering

Merkus

Particle Technology Series

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Measuring particle size in ultra-low concentration suspensions by removing the number fluctuation contribution in dynamic light scattering

et al. 2021

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In ultra-low concentration suspensions, particle number fluctuations in the scattering volume add a long delay component to the intensity autocorrelation function (ACF) in dynamic light scattering (DLS) measurements. This gives a strong artifact peak in the particle size distribution (PSD) recovered. To improve the accuracy of DLS at ultra-low concentrations, we analyzed the different decay characteristics of particle Brownian motion and particle number fluctuation in the ACF. By differentiating the ACF we were able to identify and separate the number fluctuation term and then analyze the ACF to recover the PSD. The results for simulated DLS data at 151nm and 690nm diameters with average particle numbers of 6, 12, 24 and 48 in the scattering volume at four noise levels show that, compared with the usual DLS data processing method, inversion of the ACF after the separation of the number fluctuation term effectively eliminates the strong artifact peaks, and the relative errors of peak positions and distribution errors are significantly reduced. This was further verified with experimental results from samples of standard polystyrene spheres.

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Photon Correlation Spectroscopy – Extending the limits of concentration –

Cited by 3 publications

References 1 publication

Development of a Continuous Segmented Flow Tubular Reactor and the “Scale‐out” Concept – In Search of Perfect Powders

Development of a Continuous Segmented Flow Tubular Reactor and the “Scale‐out” Concept – In Search of Perfect Powders

Dynamic Light Scattering

Measuring particle size in ultra-low concentration suspensions by removing the number fluctuation contribution in dynamic light scattering

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