Photoplethysmography for demarcation of cutaneous squamous cell carcinoma

Rasmussen, Simon Mylius; Nielsen, Thomas; Hody, Sofie; Hager, Henrik; Schousboe, Lars Peter

doi:10.1038/s41598-021-00645-4

Cited by 6 publications

(4 citation statements)

References 26 publications

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“…The PI was calculated as the ratio between the mean and maximum amplitude of the rPPG signal in the specific time window according to Rasmussen et al 71 but using the normalized green value 48 , 68 where , , and are the pixel-wise RGB components of the image frame. The value (Eq.…”

Section: Methodsmentioning

confidence: 99%

Continuous intraoperative perfusion monitoring of free microvascular anastomosed fasciocutaneous flaps using remote photoplethysmography

Schraven

Kossack

Strüder

et al. 2023

Sci Rep

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Flap loss through limited perfusion remains a major complication in reconstructive surgery. Continuous monitoring of perfusion will facilitate early detection of insufficient perfusion. Remote or imaging photoplethysmography (rPPG/iPPG) as a non-contact, non-ionizing, and non-invasive monitoring technique provides objective and reproducible information on physiological parameters. The aim of this study is to establish rPPG for intra- and postoperative monitoring of flap perfusion in patients undergoing reconstruction with free fasciocutaneous flaps (FFCF). We developed a monitoring algorithm for flap perfusion, which was evaluated in 15 patients. For 14 patients, ischemia of the FFCF in the forearm and successful reperfusion of the implanted FFCF was quantified based on the local signal. One FFCF showed no perfusion after reperfusion and devitalized in the course. Intraoperative monitoring of perfusion with rPPG provides objective and reproducible results. Therefore, rPPG is a promising technology for standard flap perfusion monitoring on low costs without the need for additional monitoring devices.

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Section: Methodsmentioning

confidence: 99%

Continuous intraoperative perfusion monitoring of free microvascular anastomosed fasciocutaneous flaps using remote photoplethysmography

Schraven

Kossack

Strüder

et al. 2023

Sci Rep

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“…Although most melanomas are pigmented, around 5–10% of cutaneous melanomas are amelanotic, which may cause delayed detection and worse prognosis ( Chen and Sebaratnam, 2021 ; Chuchvara et al, 2021 ). From dermoscopy through reflectance confocal microscopy (RCM) to histology, this condition emphasizes difficulties in the diagnosis of amelanotic melanoma ( Li et al, 2021 ; Rasmussen et al, 2021 ; Williams et al, 2021 ).…”

Section: Dilemma Of Skin Cancer Theranosticsmentioning

confidence: 99%

Functionalization of Nanomaterials for Skin Cancer Theranostics

Zhang

Zhu

Hou

et al. 2022

Front. Bioeng. Biotechnol.

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Skin cancer has drawn attention for the increasing incident rates and high morbidity worldwide. Timely diagnosis and efficient treatment are of paramount importance for prompt and effective therapy. Thus, the development of novel skin cancer diagnosis and treatment strategies is of great significance for both fundamental research and clinical practice. Recently, the emerging field of nanotechnology has profoundly impact on early diagnosis and better treatment planning of skin cancer. In this review, we will discuss the current encouraging advances in functional nanomaterials for skin cancer theranostics. Challenges in the field and safety concerns of nanomaterials will also be discussed.

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“…Melanoma skin cancer (MSC) is developed by uncontrolled proliferation and invasive spreading of abnormal melanocytes. Melanomas are predominantly pigmented, but a small percentage of cutaneous melanomas are amelanotic [ 3 , 4 ], which poses difficulty in its early diagnosis, leading to a delayed therapeutic intervention [ 5 , 6 ]. Melanomas represent the fastest-increasing cancer globally, with an annual increase of 3–8% in the incidence among the European population [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Enhancing Skin Cancer Immunotheranostics and Precision Medicine through Functionalized Nanomodulators and Nanosensors: Recent Development and Prospects

Farhana

2023

IJMS

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Skin cancers, especially melanomas, present a formidable diagnostic and therapeutic challenge to the scientific community. Currently, the incidence of melanomas shows a high increase worldwide. Traditional therapeutics are limited to stalling or reversing malignant proliferation, increased metastasis, or rapid recurrence. Nonetheless, the advent of immunotherapy has led to a paradigm shift in treating skin cancers. Many state-of-art immunotherapeutic techniques, namely, active vaccination, chimeric antigen receptors, adoptive T-cell transfer, and immune checkpoint blockers, have achieved a considerable increase in survival rates. Despite its promising outcomes, current immunotherapy is still limited in its efficacy. Newer modalities are now being explored, and significant progress is made by integrating cancer immunotherapy with modular nanotechnology platforms to enhance its therapeutic efficacy and diagnostics. Research on targeting skin cancers with nanomaterial-based techniques has been much more recent than other cancers. Current investigations using nanomaterial-mediated targeting of nonmelanoma and melanoma cancers are directed at augmenting drug delivery and immunomodulation of skin cancers to induce a robust anticancer response and minimize toxic effects. Many novel nanomaterial formulations are being discovered, and clinical trials are underway to explore their efficacy in targeting skin cancers through functionalization or drug encapsulation. The focus of this review rivets on theranostic nanomaterials that can modulate immune mechanisms toward protective, therapeutic, or diagnostic approaches for skin cancers. The recent breakthroughs in nanomaterial-based immunotherapeutic modulation of skin cancer types and diagnostic potentials in personalized immunotherapies are discussed.

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Photoplethysmography for demarcation of cutaneous squamous cell carcinoma

Cited by 6 publications

References 26 publications

Continuous intraoperative perfusion monitoring of free microvascular anastomosed fasciocutaneous flaps using remote photoplethysmography

Continuous intraoperative perfusion monitoring of free microvascular anastomosed fasciocutaneous flaps using remote photoplethysmography

Functionalization of Nanomaterials for Skin Cancer Theranostics

Enhancing Skin Cancer Immunotheranostics and Precision Medicine through Functionalized Nanomodulators and Nanosensors: Recent Development and Prospects

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