Photopolymerizable hybrid sol gel coating as a barrier against plasticizer release

Massard, Christophe; Bernard, Lise; Cueff, R.; Raspal, Vincent; Feschet-Chassot, E.; Sibaud, Yves; Sautou, V.; Awitor, Komla Oscar

doi:10.1016/j.porgcoat.2012.04.005

Cited by 9 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The film deposited on the surface of the PVC is an organic/inorganic hybrid layer, generated by the hydrolysis and condensation of a mixture of titanium alkoxide functionalized by an acrylic acid and methacrylate grafted alkoxysilane. The results we obtained are promising in so far as the coating provides not only a barrier against DEHP release but also offers a high good transparency to the coated polymer surface, which is not altered by the treatment …”

Section: Introductionmentioning

confidence: 75%

“…To limit plasticizer migration, some authors have proposed physical and chemical techniques such as covalent attachment of the plasticizer to the PVC chain, polyethylene oxide coating, chemical vapor deposition, and nucleophilic substitution of PVC with dithiocarbamate . In a previous study, we also demonstrate the efficiency of a photopolymerizable hybrid sol gel coating against DEHP release from pharmaceutical PVC bags . The film deposited on the surface of the PVC is an organic/inorganic hybrid layer, generated by the hydrolysis and condensation of a mixture of titanium alkoxide functionalized by an acrylic acid and methacrylate grafted alkoxysilane.…”

Section: Introductionmentioning

confidence: 84%

“…So, the aim of this study was: – to evaluate the efficiency of the barrier effect of our hybrid sol gel on DEHP leaching over time, to know if the protection does last for more than 1 h, as demonstrated in our previous study . Indeed, clinical situations like the infusion of a drug with an PVC infusion set and/or from a PVC bag are often made over a several hours period. – to check if the hybrid layer could also prevent drug sorption over time into PVC bags. …”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Hybrid sol gel coating: A solution to prevent interactions between plasticized poly(vinyl chloride) and injectable drugs?

Bernard

Cueff

Massard

et al. 2013

J of Applied Polymer Sci

View full text Add to dashboard Cite

During the infusion of drugs with medical devices in plasticized poly(vinyl chloride) (PVC) release of plasticizers in the injectable solution and/or sorption of drugs on PVC may occur. Thus, patient safety and/or effectiveness of his therapy may be altered. In this study, we assessed the efficiency of a sol gel hybrid coating in preventing plasticizers' release (di-(2-ethylhexyl) phthalate (DEHP)) from PVC matrix and drug sorption into PVC. Remaining concentrations of drugs and plasticizer's concentration released after migration tests were assessed by liquid chromatography. Migration processes were followed by Fourier Transform Infrared -Attenuated Total Reflectance (FTIR-ATR) spectroscopy and PVC surface changes were characterized by scanning electron microscopy (SEM). An evaluation of the mechanical properties of both uncoated and coated polymer was done. The hybrid coating protects PVC from plasticizers leaching. Sorption of drugs tested is also limited. However, the protection against plasticized PVC interactions isn't optimal, probably due to a degradation of the layer, as shown on SEM microphotographs. Furthermore improvements might provide an efficient barrier to advert risks impaired to PVC interactions, to provide patient care safety. V C 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40145.

show abstract

Section: Introductionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Hybrid sol gel coating: A solution to prevent interactions between plasticized poly(vinyl chloride) and injectable drugs?

Bernard

Cueff

Massard

et al. 2013

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…154 Photopolymerizable hybrid sol-gel coating prevented release of plasticizer from PVC during photodegradation. 155 The coating protects the PVC substrate against the UVA degradation and prevents leaching of plasticizers up to 98%. 155 …”

Section: Plasticizersmentioning

confidence: 99%

“…155 The coating protects the PVC substrate against the UVA degradation and prevents leaching of plasticizers up to 98%. 155 …”

Section: Plasticizersmentioning

confidence: 99%

Effect of Additives on Weathering

Wypych¹

2013

Handbook of Material Weathering

View full text Add to dashboard Cite

Effect of liquid plasticizers on crystallization of PCL in soft PVC/PCL/plasticizer blends

Xiong

Guo

2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

In this work, poly(ε‐caprolactone) (PCL) and liquid plasticizer were combined used to plasticize poly(vinyl chloride) (PVC), and the possibility of using PVC/PCL/plasticizer blends to fabricate soft PVC with enhanced migration resistance was investigated. Through partial replacement of liquid plasticizers in soft PVC by equal quantity of PCL, flexibility was maintained while extraction loss of plasticizer by organic solvent was reduced significantly. Furthermore, crystallization of PCL in PVC/PCL/plasticizer blends with low PCL content was observed, and crystallization rate of PCL was found to be influenced by plasticizer contents and structures. For instance, crystallization rate of PCL in PVC/PCL/diisononyl phthalate (DINP) (100/40/100) was 3.7 times faster than in PVC/PCL/DINP (100/40/80), while crystallization rate of PCL in PVC/PCL/dioctyl adipate(DOA)(100/40/100) was 8.3 times faster than in PVC/PCL/diisononyl cyclohexane‐1,2‐dicarboxylate (DINCH) (100/40/100). Low‐field 1H NMR test manifested that different crystallization rate of PCL in PVC/PCL/plasticizer blends with different plasticizer structures was triggered by difference in plasticizers' compatibility with PVC, that is, the number of interaction point between PVC and plasticizers. It is concluded that PCL crystallization favored by liquid plasticizers in PVC/PCL/plasticizer blends was induced by interaction competition between PVC/plasticizer and PVC/PCL. As plasticizer content increases or its compatibility with PVC decreases, interaction competition becomes more intense and consequently faster crystallization of PCL occurs. Thus, to obtain soft PVC products with improve migration resistance while avoiding PCL crystallization, the total content of plasticizer (including both liquid plasticizer and PCL) should be lower than 66 phr (40 wt %). © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48803.

show abstract

Photopolymerizable hybrid sol gel coating as a barrier against plasticizer release

Cited by 9 publications

References 33 publications

Hybrid sol gel coating: A solution to prevent interactions between plasticized poly(vinyl chloride) and injectable drugs?

Hybrid sol gel coating: A solution to prevent interactions between plasticized poly(vinyl chloride) and injectable drugs?

Effect of Additives on Weathering

Effect of liquid plasticizers on crystallization of PCL in soft PVC/PCL/plasticizer blends

Contact Info

Product

Resources

About