Photopolymerization of cell-laden gelatin methacryloyl hydrogels using a dental curing light for regenerative dentistry

Abstract

The proposed method to photopolymerize GelMA cell-laden hydrogels using a dental curing light is effective and represents an important step towards the establishment of chair-side procedures in regenerative dentistry.

Applications of nano-materials in diverse dentistry regimes

“…Bio-synthesis refers to a green and ecofriendly strategy for synthesizing nano-materials, which is relatively less toxic and with the possible use of biodegradable materials. 15 It deploys bacteria, plant extracts, fungi, and enzymes accompanied by precursors for generating nanoparticles rather than traditional chemicals for bio-reduction and capping purposes. The bio-synthesized nano-materials have certain improved biocompatibility features that are useful for bio-medical applications.…”

“…This is an increasing public health problem because of the fast enhancement in the elderly population as tooth retention enhances in seniors. 14,15 The vulnerability to the root caries may be increased by gingival recession because of aging, periodontal diseases, or traumatic tooth-brushing habits. 133,134 Moreover, small salivary ows in seniors and patients suffering from dry mouth have an additional role in biolm and plaque formation, and occurrence of root caries.…”

“…[11][12][13][14] These efforts suffer from key disadvantages, which require more efficient strategies and novel technologies in contemporary dentistry. [15][16][17][18] Nanoparticles, unlike other biomaterials, present distinct biological properties and can be used in novel applications in restorative dentistry, prosthetic dentistry, endodontics, implantology, oral cancers, and periodontology. Nanoparticles have immense potential because of their antimicrobial, antiviral, and antifungal properties.…”

Human articular cartilage repair: Sources and detection of cytotoxicity and genotoxicity in photo-crosslinkable hydrogel bioscaffolds

“…It has higher water solubility compared with Irgacure 2959, thus permits cell encapsulation in PEGDA at lower PI concentrations and shorter light exposure times while maintaining >95% viability of human neonatal fibroblasts . In a comparison between UV (365 nm, 1560 mW/cm 2 , 5 seconds) and visible light (405 nm, 1650 mW/cm 2 , 5 seconds), irradiation of GelMa encapsulated odontoblast‐like cells with Irgacure 2959 and LAP, respectively, under the similar intensity, cell viability was significantly higher in cells exposed to the higher wavelength . Interestingly, a marked reduction was observed following 20 seconds of light exposure in the visible light/LAP samples which was not reflected in a UV/Irgacure group which exhibited superior viability for this crosslinking time.…”

Engineering Tough, Injectable, Naturally Derived, Bioadhesive Composite Hydrogels

“…[ 8 ] The integration of sealant biomaterials with tissues undergoing extensive daily activities, such as stretching and contraction, is an unmet clinical need that requires stretchable and biocompatible material platforms. Various tissue injuries, such as skin and muscle laceration and burn, [ 9–11 ] cardiac trauma, [ 12 ] lung puncture, [ 13–18 ] liver bleeding, [ 19 ] cornea wounds, [ 20,21 ] and teeth and gum injuries [ 22–26 ] as well the anastomosis of tubular tissues [ 27–30 ] have been treated with tissue adhesive biomaterials to leverage a regenerative microenvironment while providing a physical support.…”