Photoprotection by dietary phenolics against melanogenesis induced by UVA through Nrf2-dependent antioxidant responses

Chaiprasongsuk, Anyamanee; Onkoksoong, Tasanee; Pluemsamran, Thanyawan; Limsaengurai, Saowalak; Panich, Uraiwan

doi:10.1016/j.redox.2015.12.006

Cited by 98 publications

(130 citation statements)

References 42 publications

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“…3) and their derivatives have been reported to display anti-tyrosinase activity. Recently, Chaiprasongsuk et al (2016) studied the anti-melanogenesis effect of dietary phenolic compounds (caffeic acid (CA), ferulic acid (FA), quercetin (QU), rutin (RU) and avobenzone (AV)) shortly after exposure of B16F10 melanoma cells to UVA radiation. Inhibition of melanin content, as well as inhibition of tyrosinase activity, was evaluated.…”

Section: Anti-tyrosinase Activitymentioning

confidence: 99%

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Taofiq

González-Paramás

Martins

et al. 2016

Industrial Crops and Products

158

114

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a b s t r a c tThe cosmetic industry is constantly in search of ingredients from natural sources because of their competitive effectiveness and lower toxicity effects. Mushrooms have been an important part of our diet for years and are now finding their way as cosmetic ingredients, either as cosmeceutical or as nutricosmetics. The present review focuses on the most relevant activities of mushroom extracts, as well as on their bioactive compounds, which make them interesting ingredients for cosmetic formulations. Mushroom extracts, as well as their bioactive metabolites, revealed anti-tyrosinase, anti-hyaluronidase, anti-collagenase and anti-elastase activity. Emphasis was also given to their important anti-oxidant, antimicrobial and antiinflammatory potential, topics largely studied by numerous authors, making them very versatile and multi-functional cosmetic ingredients. Some of the bioactive compounds and the mechanism responsible for the activities ascribed to mushrooms were highlighted. Other activities were identified as needing to be further studied in order to identify the major compounds contributing to the target activity, as well as their mechanisms of action. Based on the above findings, mushroom extracts, as well as their bioactive metabolites, constitute important ingredients that can help to combat aging, reduce the severity of inflammatory skin disease and correct hyperpigmentation disorders. These findings and claims must be correctly supported by clinical trials and in vivo studies.

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Section: Anti-tyrosinase Activitymentioning

confidence: 99%

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Taofiq

González-Paramás

Martins

et al. 2016

Industrial Crops and Products

158

114

View full text Add to dashboard Cite

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“…In DB-1 melanoma cells overexpressing tyrosinase, quercetin administration led to significant increase of p53 protein and the number of cells in apoptosis compared to untreated cells (8). In particular, quercetin may potentiate p53-dependent apoptosis in melanocytic cells via stimulation of nuclear factor E2-related factor 2 (Nrf2) transcriptional activity, which has been observed in various cell types including human hepatoblastoma HepG2 cells (85, 86), human BJ foreskin fibroblasts and skin HaCaT keratinocytes (87), rat DI TNC1 astrocytes (88), and UVA-irradiated mouse B16F10 melanoma cells (89). Nrf2 is a basic leucine zipper (bZIP) transcription factor that induces the expression of several genes involved in cellular redox reactions, drug metabolism and transport, energy metabolism, and intracellular iron homeostasis in response to oxidative and electrophilic stress (90).…”

Section: Transcription Of Relevant Genesmentioning

confidence: 99%

“…Quercetin has been demonstrated to induce Nrf2-mediated ARE activation in vitro in human hepatoblastoma HepG2 cells (85, 86), human BJ foreskin fibroblasts and skin HaCaT keratinocytes (87), rat DI TNC1 astrocytes (88), and UVA-irradiated mouse B16F10 melanoma cells (89). Tanigawa et al demonstrated the ability of quercetin treatment to upregulate ARE transcription by regulating both Nrf2 and Keap1 in HepG2 cells (85).…”

Section: Transcription Of Relevant Genesmentioning

confidence: 99%

“…Loss of Nrf2 activity appears to play a role in melanogenesis (89). In primary human epidermal melanocytes and mouse B16F10 melanoma cells, siRNA-mediated silencing of Nrf2 enhances melanogenesis after UVA-radiation exposure (89).…”

Section: Transcription Of Relevant Genesmentioning

confidence: 99%

“…In primary human epidermal melanocytes and mouse B16F10 melanoma cells, siRNA-mediated silencing of Nrf2 enhances melanogenesis after UVA-radiation exposure (89). In B16F10 cells, UVA radiation alone significantly decreased Nrf2 nuclear translocation and ARE–luciferase activity 1 h post-irradiation.…”

Section: Transcription Of Relevant Genesmentioning

confidence: 99%

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Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy

et al. 2016

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Replacing current refractory treatments for melanoma with new prevention and therapeutic approaches is crucial in order to successfully treat this aggressive cancer form. Melanoma develops from neural crest cells, which express tyrosinase – a key enzyme in the pigmentation pathway. The tyrosinase enzyme is highly active in melanoma cells and metabolizes polyphenolic compounds; tyrosinase expression thus makes feasible a target for polyphenol-based therapies. For example, quercetin (3,3′,4′,5,7-pentahydroxyflavone) is a highly ubiquitous and well-classified dietary polyphenol found in various fruits, vegetables, and other plant products including onions, broccoli, kale, oranges, blueberries, apples, and tea. Quercetin has demonstrated antiproliferative and proapoptotic activity in various cancer cell types. Quercetin is readily metabolized by tyrosinase into various compounds that promote anticancer activity; additionally, given that tyrosinase expression increases during tumorigenesis, and its activity is associated with pigmentation changes in both early- and late-stage melanocytic lesions, it suggests that quercetin can be used to target melanoma. In this review, we explore the potential of quercetin as an anti-melanoma agent utilizing and extrapolating on evidence from previous in vitro studies in various human malignant cell lines and propose a “four-focus area strategy” to develop quercetin as a targeted anti-melanoma compound for use as either a preventative or therapeutic agent. The four areas of focus include utilizing quercetin to (i) modulate cellular bioreduction potential and associated signaling cascades, (ii) affect transcription of relevant genes, (iii) regulate epigenetic processes, and (iv) develop effective combination therapies and delivery modalities/protocols. In general, quercetin could be used to exploit tyrosinase activity to prevent, and/or treat, melanoma with minimal additional side effects.

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NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products

2022

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The skin is the organ that is most susceptible to the impact of the exposome.Located at the interface with the external environment, it protects internal organs through the barrier function of the epidermis. It must adapt to the consequences of the harmful effects of solar radiation, the various chemical constituents of atmospheric pollution, and wounds associated with mechanical damage: oxidation, cytotoxicity, inflammation, and so forth. In this biological context, a capacity to adapt to the various stresses caused by the exposome is essential; otherwise, more or less serious conditions may develop accelerated aging, pigmentation disorders, atopy, psoriasis, and skin cancers. Nrf2-controlled pathways play a key role at this level. Nrf2 is a transcription factor that controls genes involved in oxidative stress protection and detoxification of chemicals. Its involvement in UV protection, reduction of inflammation in processes associated with healing, epidermal differentiation for barrier function, and hair regrowth, has been demonstrated. The modulation of Nrf2 in the skin may therefore constitute a skin protection or care strategy for certain dermatological stresses and disorders initiated or aggravated by the exposome. Nrf2 inducers can act through different

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Photoprotection by dietary phenolics against melanogenesis induced by UVA through Nrf2-dependent antioxidant responses

Cited by 98 publications

References 42 publications

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review

Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy

NRF2 in dermo‐cosmetic: From scientific knowledge to skin care products

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