Photoprotective Effect of a &lt;i&gt;Polyopes affinis&lt;/i&gt; (Harvey) Kawaguchi and Wang (&lt;i&gt;Halymeniaceae&lt;/i&gt;)-Derived Ethanol Extract on Human Keratinocytes

Hyun, YJ; Piao, MJ; Kc, Kim; Zheng, Jian; Yao, CW; Cha, JW; Kang, Hyun-Kyu; Yoo, ES; Koh, YS; Nh, Lee; Ko, MH; Hyun, JW

doi:10.4314/tjpr.v13i6.6

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…In general, the constituents of seaweeds can be largely divided into pigment substances, amino acids, sterols, and polyphenols. Red algae are known to contain carotenoids and chlorophyll C. Previous studies have shown the UV-protection effect of P. affinis in HaCaT cells [ 47 ], the inhibitory effect toward allergic asthma in a murine models [ 11 ], the inflammatory effect in LPS-induced RAW 264.7 cells [ 48 ], and the skin-whitening effect in B16F10 cells [ 49 ]. However, the active ingredient in P. affinis has not been investigated.…”

Section: Discussionmentioning

confidence: 99%

Polyopes affinis Suppressed IFN-γ- and TNF-α-Induced Inflammation in Human Keratinocytes via Down-Regulation of the NF-κB and STAT1 Pathways

Lee

Kim

et al. 2022

Molecules

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Polyopes affinis is a red algal species commonly found on the South coast and near Jeju Island, Korea. This study aimed to determine whether P. affinis extracts can inhibit the pathogenesis of T-helper-2 (Th2)-mediated inflammation in a human keratinocyte cell line of atopic dermatitis (AD). Cells were incubated with 10 ng/mL of interferon gamma (IFN-γ) and 10 ng/mL of tumor necrosis factor-alpha (TNF-α) at various concentrations of PAB (10, 30, and 60 µg/mL) and PAA (100, 500, and 1000 µg/mL) extracts. A gene-ontology (GO)-enrichment analysis revealed that PAB significantly enriched the genes associated with biological processes such as cell adhesion, immune response, inflammation, and chemokine-mediated pathways. PAB suppressed the expression of the secretory proteins and mRNAs that are associated with the thymus and the production of activation-regulated chemokines (TARC/CCL17) and macrophage-derived chemokines (MDC/CCL22). The effect of the extract on mitogen-activated protein kinases (MAPKs) was related to its inhibition of TARC/CCL17 and MDC/CCL22 production by blocking NF-κB and STAT1 activation. These results suggest that seaweed extract may improve AD by regulating pro-inflammatory chemokines. In conclusion, we first confirmed the existence of phloroglucinol, a polyphenol formed from a precursor called phlorotannin, which is present in PAB, and this result proved the possibility of PAB being used as a treatment for AD.

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Section: Discussionmentioning

confidence: 99%

Polyopes affinis Suppressed IFN-γ- and TNF-α-Induced Inflammation in Human Keratinocytes via Down-Regulation of the NF-κB and STAT1 Pathways

Lee

Kim

et al. 2022

Molecules

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“…This study also demonstrated the ability of this extract to provide anti-inflammatory protection in animals using BALB/c mice (Lee et al 2013a ). A study demonstrated that Polyopes affinis (Harvey) Kawaguchi and Wang to reduce ROS, cell damage, and apoptosis induced by UVB in HaCaT cells (Hyun et al 2014 ). Another study was conducted on Polysiphonia morrowii which demonstrated to provide scavenging activity against ROS, apoptosis, and DNA fragmentation induced by UVB in HaCaT cells (Piao et al 2012 ).…”

Section: In Vitro and In Vivo Studies Based On Radiation-induced Damagementioning

confidence: 99%

Advances on marine-derived natural radioprotection compounds: historic development and future perspective

Abraham

Alghazwi

Liang

et al. 2021

Mar Life Sci Technol

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Natural extracts and compounds from marine resources have gained intensive scientific and industry attention for radioprotective activities in the past ten years. However, the marine-derived radioprotectants have been studied against UV-rays, gamma (γ)-rays and X-rays for more than 30 years. This review aims to identify key marine-derived extracts/compounds and their modes of action studied for radioprotective activities from 1986 to 2019. A comprehensive survey was conducted to establish the trend in terms of the publications each year and the countries of origin. A total of 40 extracts and 34 natural compounds showing radioprotective activities against UV-rays, gamma (γ)-rays and X-rays were identified from a range of marine plants and animals. These extracts and compounds are broadly categorized into polysaccharides, phlorotannins, carotenoids and mycosporine-like amino acids (MAAs). Macroalgae and microalgae were found to be the dominant sources of polysaccharides, phlorotannins and carotenoids. MAAs were mainly identified in algae, sponges, sea cucumber and corals that showed significant UV-absorbing activities. A number of radioprotective mechanisms were shown by these compounds, predominantly free radicals scavenging, inhibition of apoptosis, UV-ray absorption and DNA damage-repair signaling pathways. While these bio-discoveries warrant further investigation and development of radioprotective therapeutics, however, the lack of clinical studies is a major obstacle to be tackled in the future.

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Cosmetic and Dermatological Application of Seaweed: Skincare Therapy-Cosmeceuticals

Gokbulut

2024

Seaweeds and Seaweed-Derived Compounds

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Photoprotective Effect of a <i>Polyopes affinis</i> (Harvey) Kawaguchi and Wang (<i>Halymeniaceae</i>)-Derived Ethanol Extract on Human Keratinocytes

Abstract: Purpose: To investigate the photoprotective effect of the ethanol extract of the red marine alga, Polyopes affinis (PAE) against ultraviolet B (UVB) radiation

Cited by 7 publications

References 19 publications

Polyopes affinis Suppressed IFN-γ- and TNF-α-Induced Inflammation in Human Keratinocytes via Down-Regulation of the NF-κB and STAT1 Pathways

Polyopes affinis Suppressed IFN-γ- and TNF-α-Induced Inflammation in Human Keratinocytes via Down-Regulation of the NF-κB and STAT1 Pathways

Advances on marine-derived natural radioprotection compounds: historic development and future perspective

Cosmetic and Dermatological Application of Seaweed: Skincare Therapy-Cosmeceuticals

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