Photoprotective effect of sesamol on UVB-radiation induced oxidative stress in human blood lymphocytes in vitro

Prasad, Nagarajan Rajendra; Thirunavukkarasu, Mahesh; Menon, Venugopal P.; Jeevanram, R.K.; Pugalendi, Kodukkur Viswanathan

doi:10.1016/j.etap.2004.09.009

Cited by 52 publications

(23 citation statements)

References 46 publications

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“…Sesamol is formed from decomposition of sesamolin during the processing of sesame oil. Sesamol is a powerful antioxidant and inhibits UV-and Fe3+/ascorbate-induced lipid peroxidation in rat brain (Ando et al 2000;Prasad et al 2005a;Uchida et al 1996). Sesamol reduces ferric ions, and its unique solubility in both aqueous and oily phases increases its local concentration in cell membranes and makes it a chainbreaking antioxidant (Uchida et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences

2010

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Section: Introductionmentioning

confidence: 99%

Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences

2010

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“…Numerous wild relative species are found in Africa and a smaller number in India. SA has various activities such as antioxidant, antifungal, neuroprotective [5], photoprotective [6], and hepatoprotective [7]. Along with SA, folic acid (FA) was combined, as FA involved in the synthesis of DA and it is to be noted that FA deficiency causes PD [8].…”

Section: Introductionmentioning

confidence: 99%

Effect of Sesamol in Association With Folic Acid on 6-Ohda Induced Parkinsonian Animals- Biochemical, Neurochemical and Histopathological Evidence

Sereen

Krishnamurthy²,

Nagappan³

et al. 2017

Asian J Pharm Clin Res

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Objective: Parkinson's disease (PD) is the world's second neurodegenerative disorder. Degeneration of dopaminergic neurons is the hallmark of the disease. Here is a novel approach to treat PD with a phenolic compound Sesamol (SA) and in combination with folic acid (FA). Methods:The study was designed with five groups of animals and 6 rats in each group. The rats were infused with 6-hydroxydopamine (10 μg/2 μl in 0.1% ascorbic acid saline) once for the development of PD, Group 1 (control), Group 2 (lesion), Group 3 (lesion+SA), Group 4 (lesion+SA+FA), and Group 5 (lesion+L-dopa). The biochemical parameters such as glucose, triglycerides, protein, FA, thiobarbituric acid reactive substance (TBARS), and antioxidant profile in serum were estimated. The neurotransmitters level in striatum was estimated, and histopathology of striatum and midbrain tissues was carried out. Results:The results showed that 6-hydroxydopamine induced lesion has a significant alteration in the level of glucose, triglycerides, protein and FA, whereas TBARS level was elevated and the activities of antioxidants and neurotransmitters level were reduced. This was significantly restored on SA and FA treatment. The lesion group shows an abnormal architecture of striatum and midbrain, whereas on SA and FA treatment there was minimal abnormality.Conclusion: Thus, our study demonstrates that SA has a neuroprotective effect against 6-hydroxydopamine insult and showed a synergic effect when combined with FA.

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“…SES (100 µM) alone treated cells show similar results as vehicle control. SES, a powerful antioxidant inhibits lipid peroxidation [44] as reported by Prasad et al Fig. 8-11 shows the activities of CAT, SOD, GPx and the level of GSH in ROT-induced SH-SY5Y cells with and without SES.…”

Section: Resultsmentioning

confidence: 96%

“…Khadira Screen and Vijayalakshmi have reported SES as an efficient antioxidant [12] which protects the cells from free radical injury. SES is a traditionally used health supplement which exerts photoprotective [13], chemopreventive [14], hepatoprotective [15], antiinflammatory [16], anti-aging [17] and anti-depressant [18] activities. SH-SY5Y cells exhibits neuronal marker enzymes like tyrosine hydroxylase, dopamine-beta-hydroxylase, dopamine transporters and neuroinflammation proteins [19].…”

Section: Introductionmentioning

confidence: 99%

Sesamol Antagonizes Rotenone-Induced Cell Death in Sh-Sy5y Neuronal Cells

Rohini

Krishnamurthy

2016

Int J Pharm Pharm Sci

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Objective: To investigate the neuroprotective effect of sesamol against rotenone-induced cell death in SH-SY5Y cells associated with Parkinsonism.Methods: SH-SY5Y cells were maintained in Dulbecco's modified Eagle's medium. After differentiation, the cells were incubated with rotenone (20 μM) and sesamol at different concentrations (10-100 μM). Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay. The reactive oxygen species, mitochondrial membrane potential and nuclear morphology were determined by dichlorofluorescein diacetate, rhodamine 123 and 4', 6-diamidino-2-phenylindole, respectively. Thiobarbituric acid reactive substances, activities of catalase, superoxide dismutase, and glutathione peroxidase and glutathione level were determined by standard assays. Results:Sesamol significantly increased the cell viability and decreased the rotenone-induced cell death in SH-SY5Y cells. Sesamol antagonized rotenone-induced reactive oxygen species generation, loss of mitochondrial membrane potential and nuclear damage. Sesamol also decreased thiobarbituric acid reactive substances level, increased the activities of catalase, superoxide dismutase, glutathione peroxidase and increased the level of glutathione in rotenone-induced cells. Conclusion:The results obtained strongly indicate the promising neuroprotective role of sesamol against rotenone-induced death in SH-SY5Y cells.

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Photoprotective effect of sesamol on UVB-radiation induced oxidative stress in human blood lymphocytes in vitro

Cited by 52 publications

References 46 publications

Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences

Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences

Effect of Sesamol in Association With Folic Acid on 6-Ohda Induced Parkinsonian Animals- Biochemical, Neurochemical and Histopathological Evidence

Sesamol Antagonizes Rotenone-Induced Cell Death in Sh-Sy5y Neuronal Cells

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