Titanium dioxide (TiO2), owing to its non-toxicity, chemical stability, and low cost, is one of the most valuable ceramic materials. TiO2 derived coatings not only act like a ceramic protective shield for the metallic substrate but also provide cathodic protection to the metals against the corrosive solution under Ultraviolet (UV) illumination. Being biocompatible, TiO2 coatings are widely used as an implant material. The acid treatment of TiO2 promotes the attachment of cells and bone tissue integration with the implant. In this chapter, the applications of TiO2 as a corrosion inhibitor and bioactive material are briefly discussed. The semiconducting nature and high refractive index of TiO2 conferred UV shielding properties, allowing it to absorb or reflect UV rays. Several studies showed that a high ultraviolet protection factor (UPF) was achieved by incorporating TiO2 in the sunscreens (to protect the human skin) and textile fibers (to minimize its photochemical degradation). The rutile phase of TiO2 offers high whiteness, and opacity owing to its tendency to scatter light. These properties enable TiO2 to be used as a pigment a brief review of which is also addressed in this chapter. Since TiO2 exhibits high hardness and fracture toughness, the wear rate of composite is considerably reduced by adding TiO2. On interacting with gases like hydrogen at elevated temperatures, the electrical resistance of TiO2 changes to some different value. The change in resistance can be utilized in detecting various gases that enables TiO2 to be used as a gas sensor for monitoring different gases. This chapter attempts to provide a comprehensive review of applications of TiO2 as an anti-corrosion, wear-resistant material in the mechanical field, a UV absorber, pigment in the optical sector, a bioactive material in the biomedical field, and a gas sensor in the electrical domain.