Photoreceptor assessment in focal laser-treated central serous chorioretinopathy using adaptive optics and fundus autofluorescence

Ochinciuc, Radu; Ochinciuc, Uliana; Stanca, Horia Tudor; Barac, Ramona; Darabus, Diana; Suta, Marius Cristian; Baltă, Florian; Burcea, Marian

doi:10.1097/md.0000000000019536

Cited by 13 publications

(12 citation statements)

References 14 publications

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“…AO-SLO is an imaging tool that can be used to evaluate retinal layer integrity and changes in visual outcomes before and after resolution of CSCR. It can be combined with other devices such as fundus camera and OCT to detect changes in photoreceptor mosaic pattern in patients with CSCR [ 31 , 32 ]. The AO-SLO is able to detect decrease in cone density and disruption of inner segment/outer segment (IS/OS) or intermediate line on OCT [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Current Choroidal Imaging Findings in Central Serous Chorioretinopathy

Nkrumah

Maltsev

Manuel

et al. 2020

Vision

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Background: Central serous chorioretinopathy (CSCR) is a chorioretinal disease affecting mostly middle age males. It is marked by the serous detachment of the neurosensory layer at the macula. This review of the literature provides a framework of the current characteristic/relevant imaging findings of CSCR. Although the pathogenesis of CSCR is unclear, the choroid plays a major role and its changes are fundamental to the diagnosis and treatment of CSCR. Methods: A systematic literature search focusing on current multimodal imaging for CSCR was performed. Only articles reporting on original clinical data were selected, studies in a language other than English were included only if an English abstract was provided. Additional sources included articles cited in the references list of the first selected articles. We deduced imaging findings based on current and relevant literature on the topic. Results: We found that sub foveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) were greater in eyes with acute CSCR than in eyes with chronic CSCR or normal eyes. There was increased choroidal thickness (CT) in the macula compared to peripapillary region. In healthy eyes, the highest CVI was found in the nasal region followed by the inferior, temporal, and superior quadrant. The area with the least CVI was the macula. In eyes with CSCR, 100% had asymmetric dominant vortex veins compared to 38% in normal eyes. Conclusion: Choroidal imaging has advanced the diagnosis of CSCR. This has led to numerous imaging biomarkers like CVI, CT, and hyper-reflective dots for early detection and possible prognostication of CSCR. More techniques like wide field scans and en face imaging are being employed to characterize the choroid in CSCR.

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Section: Introductionmentioning

confidence: 99%

Current Choroidal Imaging Findings in Central Serous Chorioretinopathy

Nkrumah

Maltsev

Manuel

et al. 2020

Vision

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“…The presence of hypoauto uorescent lesions has already been shown to be a negative prognostic factor in CSC [8]. In the CSC case presented above, the leakage point was hypo-AF from the very beginning, indicating that in that area the RPE suffered the most.…”

Section: Discussionmentioning

confidence: 74%

“…Almost all hyper-AF lesions appeared white on AO cone mosaic and the hypo-AF ones appeared black [8].…”

Section: Two Years After the Focal Laser Photocoagulationmentioning

confidence: 96%

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Assessment of fundus autofluorescence and adaptive optics high-resolution images in macular disorders

Ochinciuc¹,

Ochinciuc²,

Baltă³

et al. 2021

Preprint

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Purpose This study analyzed and compared the results of adaptive optics (AO) and fundus autofluorescence (FAF) in various maculopathies. Methods The study included four different types of maculopathy: central serous chorioretinopathy (CSC), retinitis pigmentosa (RP), Stargardt disease (STGD) and phototoxic retinopathy. In all four cases cone mosaic and cone density were obtained using AO fundus camera. Further the high resolution images were compared with the FAF and optical coherence tomography (OCT) results. Results In CSC, FAF and AO were able to show changes in the macula even two years after the subretinal fluid resorption, as opposed to a normal OCT. The improvement of FAF and cone mosaic appearance was concomitant with the visual acuity growth. Several cone mosaic phenotypes were observed in RP and STGD. In RP the cone density was 24.240cones/mm2 in the center, and decreased to 8.163cones/mm2 in the parafoveolar area. In STGD the cone density was lower in the center, 9.219cones/mm2, and higher at the periphery, 12.594cones/mm2. In the case of phototoxic retinopathy, AO and OCT were more effective than FAF in highlighting the photoreceptor and retinal pigment epithelium lesions. Conclusions FAF and AO are very useful tools in macular pathologies examination. FAF can give us a true picture about metabolic changes in the macula while AO allows us to view changes up to the cellular level.

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“…Almost all hyper-AF lesions appeared white on AO cone mosaic and the hypo-AF ones appeared black [ 8 ]. Within a year, most black lesions on the cone mosaic decreased in size and white lesions decreased in intensity ( Fig.…”

Section: Resultsmentioning

confidence: 99%