Photoregulated Release of Noncovalent Guests from Dendritic Amphiphilic Nanocontainers

Yesilyurt, Volkan; Ramireddy, Rajasekharreddy; Thayumanavan, S.

doi:10.1002/anie.201006193

Cited by 102 publications

(84 citation statements)

References 75 publications

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“…Then we will discuss how the introduction of specific functional groups on these dendrimers renders them responsive to stimuli such as temperature, 32,33 light, 34 pH, 35 or biological stimuli such as proteins 36 and enzymes. 37 …”

Section: Introductionmentioning

confidence: 99%

Stimuli sensitive amphiphilic dendrimers

et al. 2012

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In the past decade, there has been an increasing interest in supramolecular systems that can undergo physical or chemical tranformations upon encountering a specific stimulus. Micelle-forming amphiphilic systems based on polymers and dendrimers are particularly preferred over small molecule amphiphiles, due to their ability to sequester and release a vast library of hydrophobic guest molecules at micromolar polymer or dendrimer concentrations. Here we review a relatively underexplored, yet rapidly advancing, field of amphiphilic systems based on dendritic architechture that exhibit stimuli sensitive behaviour. In particular, we will be focusing on stimuli such as temperature, pH, enzymatic and non-enzymatic proteins. These stimuli-responsive systems offer a unique opportunity in the field of drug delivery and sensing.

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Section: Introductionmentioning

confidence: 99%

Stimuli sensitive amphiphilic dendrimers

et al. 2012

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“…Thayumanavan et al synthesized light-sensitive facially amphiphilic dendrimers, which could form selfassembled aggregates in water, using a photolabile 2-nitrobenzylesters as the liphophilic units and oligoethylene glycol as the hydrophilic units. Further, they demonstrated light-induced disassembly of the dendrimers using Nile red as the liphophilic guest molecule (Yesilyurt et al 2011). Although a number of lightresponsive carrier systems using O-nitrobenzyl group have been developed, most of them are activated by UV light that may cause skin damage.…”

Section: Light-responsive Nanoparticles Using Irreversible Photo-cleamentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers as Promising Drug and Gene Delivery Systems

Saravanakumar

Kim

2014

Intracellular Delivery II

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Polymeric nanocarriers have emerged as promising drug delivery vehicles owing to their potential to selectively deliver the active agents to the disease sites through various targeting mechanisms, while minimizing the side effects. To realize more enhanced therapeutic effect, it is also highly essential to impart specific release mechanism into the nanocarriers in addition to the targeting capabilities. In this regard, stimuli-sensitive or smart polymeric nanocarriers that are responsive to inherent (e.g. pH, temperature, redox, hypoxia, enzymes, and reactive oxygen species) or external stimuli (e.g. light, ultrasound or magnetic) have received enormous attention because of their ability to control the drug release profile in a desirable fashion at the target site of action. The primary focus of this chapter is to highlight the recent advances of various stimuli-responsive nanocarriers that have been developed for a more efficient drug and gene delivery.

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“…Hydrophilic block copolymers that contain coumarin, which dimerizes when exposed to UV light, have been used to form micelles, which were then photochemically cross-linked 51 . Light-sensitive chemistry has also been used to formulate dendrimer nanocarriers that, with light exposure, release encapsulated drug 52 . These techniques are exportable to nanogel formulations, and are especially valuable since the cross-linking activity can be incorporated in such a way that it can be used to exert control over drug release by suppressing enzymatic degradation of substrate with light stimulation at one wavelength or by enhancing enzymatic degradation of substrate as a result of increased decrosslinking with light exposure at another wavelength 53 .…”

Section: Stimulus Responsive Nanogelsmentioning

confidence: 99%

Nanogel carrier design for targeted drug delivery

et al. 2014

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Polymer-based nanogel formulations offer features attractive for drug delivery, including ease of synthesis, controllable swelling and viscoelasticity as well as drug loading and release characteristics, passive and active targeting, and the ability to formulate nanogel carriers that can respond to biological stimuli. These unique features and low toxicity make the nanogels a favorable option for vascular drug targeting. In this review, we address key chemical and biological aspects of nanogel drug carrier design. In particular, we highlight published studies of nanogel design, descriptions of nanogel functional characteristics and their behavior in biological models. These studies form a compendium of information that supports the scientific and clinical rationale for development of this carrier for targeted therapeutic interventions.

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Photoregulated Release of Noncovalent Guests from Dendritic Amphiphilic Nanocontainers

Cited by 102 publications

References 75 publications

Stimuli sensitive amphiphilic dendrimers

Stimuli sensitive amphiphilic dendrimers

Stimuli-Responsive Polymeric Nanocarriers as Promising Drug and Gene Delivery Systems

Nanogel carrier design for targeted drug delivery

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