Photorejuvenation with Topical Methyl Aminolevulinate and Red Light: A Randomized, Prospective, Clinical, Histopathologic, and Morphometric Study

Issa, Maria Claudia Almeida; Piñeiro-Maceira, Juãn; Vieira, Maria Teresa Campos; Olej, Beni; Mandarim-de-Lacerda, Carlos Alberto; Luiz, Ronir Raggio; Manela-Azulay, Mônica

doi:10.1111/j.1524-4725.2009.01385.x

Cited by 52 publications

(3 citation statements)

References 14 publications

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“…PDT promotes significant improvement in fine wrinkles, mottled pigmentation, sallow complexion, skin texture, tactile roughness, telangiectasias, and facial erythema. PDT has been demonstrated to cause an increase in type I collagen and a decrease in elastotic material in the dermis, effectively reversing signs of photoaging [ 7 , 23 , 48 , 49 ]. In vitro studies have shown that PDT can enhance the production of collagen type I and collagen-degrading MMP-3 by activating extracellular signal-regulated kinase [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-aging Effects of Tirbanibulin 1% Ointment: A Real-Life Experience

Li Pomi,

Peterle,

d’Aloja

et al. 2024

Dermatol Ther (Heidelb)

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Introduction Tirbanibulin 1% ointment has been licensed to treat non-hyperkeratotic actinic keratosis (AKs) on the face and scalp in adults to ensure excellent patient tolerability due to the mild side effects and the brief application time compared to other topical therapies on the market. A growing body of evidence suggests that, beyond their primary function, the treatments for AKs and the cancerization field may inadvertently confer substantial cosmetic benefits to patients. Methods We report a single-center retrospective case series of patients referred to the Dermatology Unit of the University Hospital of Messina, Italy, between February and December 2023 seeking treatment for AKs in the context of photodamaged areas in which the application of tirbanibulin 1% ointment induced, besides clearance of AKs, anti-aging effects on both skin texture and solar lentigos. Results Seven patients affected by Olsen grade 1–2 AKs experienced a powerful rejuvenating effect in the treated areas, with a marked efficacy in skin lightening and clearance of solar lentigo. Conclusions Tirbanibulin 1% ointment seems able to improve skin aging as a desirable side effect at the site of application for AKs on chronic photodamaged skin. Such preliminary observation needs further confirmation in real-life studies on larger cohorts of patients, to explain the pathogenic mechanisms responsible for such aesthetically relevant results.

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Section: Discussionmentioning

confidence: 99%

Anti-aging Effects of Tirbanibulin 1% Ointment: A Real-Life Experience

Li Pomi,

Peterle,

d’Aloja

et al. 2024

Dermatol Ther (Heidelb)

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“…TGF-β and its receptor, which are involved in collagen synthesis, were increased, while MMP-1, 3, and 12, elastin degraders, were decreased [ 18 ]. PDT is associated with improvement of fine wrinkles, texture, and pigmentation [ 10 , 11 , 20 , 21 , 25 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Facial rejuvenation using photodynamic therapy with a novel preparation of ALA and hyaluronic acid in young adults

et al. 2020

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Photodynamic therapy (PDT) is a well-established, non-invasive treatment modality that has shown desirable effects such as improvement of fine lines, dyspigmentation, and other signs of photodamage. Many patients seek to decrease, or reverse, effects of sun damage on the skin. Hyaluronic acid (HA), a naturally occurring glycosaminoglycan found in the body, has enormous potential to bind water which allows the skin to retain moisture and maintain elasticity. Topical application of HA has been found to produce anti-wrinkle effects. We conducted a pilot case series evaluating the safety and efficacy of a commercially available 2% 5-aminolevulinic acid (ALA) gel with hyaluronic acid (ALA-HA) and light-emitting diode-red light (LED-RL) for facial rejuvenation as determined by clinical assessments and digital skin analysis of rhytides, pore size, and erythema. All patients noted improvement of their skin and experienced minimal pain during PDT. Evaluation by dermatologists demonstrated significant improvement in overall skin appearance. Digital analysis of photographs revealed improvement of skin spots, wrinkles, pores, texture, UV spots, brown spots, red areas, and porphyrins. Our findings demonstrated safety and efficacy of this novel preparation of photodynamic gel with HA and subsequent activation with LED-RL.

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“…The visual numeric scale is a gauging and unidirectional instrument of measurement, commonly used in pain analysis, and it has also been described previously in clinical trials for measuring other side effects related to photoaging treatments. 26 Therefore, it was the measurement method chosen for our study. On this scale, the grade of intensity varies from 0 to 10 (0- absent; 1 to 3- light; 4 to 7- mild; > 7 severe).…”

Section: Methodsmentioning

confidence: 99%

Fractional Erbium laser in the treatment of photoaging: randomized comparative, clinical and histopathological study of ablative (2940nm) vs. non-ablative (1540nm) methods after 3 months

Borges

Cuzzi

Mandarim-de-Lacerda

et al. 2014

An. Bras. Dermatol.

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BACKGROUNDFractional non-ablative lasers keep the epidermis intact, while fractional ablative lasers remove it, making them theoretically more effective.OBJECTIVESTo evaluate the clinical and histological alterations induced by fractional photothermolysis for treating photoaging, comparing the possible equivalence of multiple sessions of 1540nm Erbium, to one session of 2940nm Erbium.METHODSEighteen patients (mean age 55.9) completed the treatment with three sessions of 1540nm fractional Erbium laser on one side of the face (50 mJ/mB, 15ms, 2 passes), and one session of 2940nm on the other side (5mJ/mB, 0.25ms, 2 passes). Biopsies were performed before and 3 months after treatment. Clinical, histological and morphometric evaluations were carried out.RESULTSAll patients presented clinical improvement with no statistically significant difference (p> 0.05) between the treated sides. Histopathology revealed a new organization of collagen and elastic fibers, accompanied by edema, which was more evident with the 2940nm laser. This finding was confirmed by morphometry, which showed a decrease in collagen density for both treatments, with a statistical significance for the 2940nm laser (p > 0.001).CONCLUSIONSThree 1540nm sessions were clinically equivalent to one 2940nm session. The edema probably contributed to the positive results after three months, togheter with the new collagen and elastic fibers organization. The greater edema after the 2940nm session indicates that dermal remodeling takes longer than with 1540nm. It is possible that this histological superiority relates to a more prolonged effect, but a cohort longer than three months is needed to confirm that supposition.

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Photorejuvenation with Topical Methyl Aminolevulinate and Red Light: A Randomized, Prospective, Clinical, Histopathologic, and Morphometric Study

Abstract: Clinical improvement with regard to texture, firmness, wrinkle depth, skin coloration, and clearance of actinic keratoses was observed. Histopathologic and morphometric studies were consistent with the clinical findings.

Cited by 52 publications

References 14 publications

Anti-aging Effects of Tirbanibulin 1% Ointment: A Real-Life Experience

Anti-aging Effects of Tirbanibulin 1% Ointment: A Real-Life Experience

Facial rejuvenation using photodynamic therapy with a novel preparation of ALA and hyaluronic acid in young adults

Fractional Erbium laser in the treatment of photoaging: randomized comparative, clinical and histopathological study of ablative (2940nm) vs. non-ablative (1540nm) methods after 3 months

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