Photosensitivity reaction induced by erlotinib

Case of erlotinib‐induced photosensitivity

“…3 In another case, lichenoid eruption developed 100 days after the initiation of therapy. 4 The eruption type and symptom onset in the case reported here were different from these previously reported cases. The mechanism underlying erlotinib-induced photosensitivity is unknown.…”

“…A few cases of erlotinib-induced photosensitivity have been reported previously. 3,4 In one case, papulopustular eruptions such as EGFR-TKI-induced acneiform eruption developed on sun-exposure areas 2 months after the start of administration. 3 In another case, lichenoid eruption developed 100 days after the initiation of therapy.…”

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response, 2 reduced expression of the acetylcholine receptor or acetylcholinesterase in the eccrine glands. [3][4][5] However, the pathological specimens of the anhidrotic area in Case 1 showed infiltration of T cells around the sweat glands, whereas the hypohidrotic area in Case 2 showed no infiltration. This indicates that the etiology of IPSF cannot easily be explained as a T-cell-induced immune response.

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Cutaneous Adverse Drug Reactions: A Two Years Retrospective Study From A Tertiary Care Hospital In Sub Himalayan Region

“…Two immunosuppressed patients presented with photosensitive rash which was secondary to erlotinib, which is an epidermal growth factor inhibitor. Photosensitivity reaction is a rare toxicity in erlotinib treatment, which has been confirmed by a positive photo patch test (13) .Another rare finding in our study was acute generalized exanthematous pustulosis which has been rarely reported secondary to antitubercular therapy (14) . Histopathological examination was done in our case to confirm the diagnosis.…”

Vandetanib induced photoallergic dermatitis: A case report

“…The epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors cause less side effects compared to standard chemotherapeutics [4]. As the EGFRs are intensely expressed in the epidermis, the hair follicles and the sebaceous glands, these inhibitors mostly lead to dermatological side effects in 50%-100% of the cases [5].…”