Photosensitized reactive chlorine species-mediated therapeutic destruction of drug-resistant bacteria using plasmonic core–shell Ag@AgCl nanocubes as an external nanomedicine

Thangudu, Suresh; Kulkarni, Sagar Sunil; Vankayala, Raviraj; Chiang, Chi‐Shiun; Hwang, Kuo Chu

doi:10.1039/d0nr01300e

Cited by 39 publications

(22 citation statements)

References 52 publications

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“…Infectious diseases caused by pathogenic bacterial infections have become a major healthcare problems in human health and causing nearly one third of deaths globally [ 89 , 90 ]. The most common treatment for bacterial infections is usage of antibiotics.…”

Section: Pani-based Biomaterials For Eradication Of Bacterial Infementioning

confidence: 99%

Recent Advances of Polyaniline-Based Biomaterials for Phototherapeutic Treatments of Tumors and Bacterial Infections

et al. 2020

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Conventional treatments fail to completely eradicate tumor or bacterial infections due to their inherent shortcomings. In recent years, photothermal therapy (PTT) has emerged as an attractive treatment modality that relies on the absorption of photothermal agents (PTAs) at a specific wavelength, thereby transforming the excitation light energy into heat. The advantages of PTT are its high efficacy, specificity, and minimal damage to normal tissues. To this end, various inorganic nanomaterials such as gold nanostructures, carbon nanostructures, and transition metal dichalcogenides have been extensively explored for PTT applications. Subsequently, the focus has shifted to the development of polymeric PTAs, owing to their unique properties such as biodegradability, biocompatibility, non-immunogenicity, and low toxicity when compared to inorganic PTAs. Among various organic PTAs, polyaniline (PANI) is one of the best-known and earliest-reported organic PTAs. Hence, in this review, we cover the recent advances and progress of PANI-based biomaterials for PTT application in tumors and bacterial infections. The future prospects in this exciting area are also addressed.

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Section: Pani-based Biomaterials For Eradication Of Bacterial Infementioning

confidence: 99%

Recent Advances of Polyaniline-Based Biomaterials for Phototherapeutic Treatments of Tumors and Bacterial Infections

et al. 2020

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“…Recently, significant attention has been focused on nanomaterial-mediated phototherapies such as photothermal therapy (NmPTT) and photodynamic therapy (NmPDT) for the treatment of many diseases including cancers, bacterial infections, etc. [7][8][9][10][11][12]. NmPTT relies on photothermal heat and NmPDT mainly relies on reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives

Thangudu

2021

Biomolecules

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Nanomaterial-mediated cancer therapeutics is a fast developing field and has been utilized in potential clinical applications. However, most effective therapies, such as photodynamic therapy (PDT) and radio therapy (RT), are strongly oxygen-dependent, which hinders their practical applications. Later on, several strategies were developed to overcome tumor hypoxia, such as oxygen carrier nanomaterials and oxygen generated nanomaterials. Among these, oxygen species generation on nanozymes, especially catalase (CAT) mimetic nanozymes, convert endogenous hydrogen peroxide (H2O2) to oxygen (O2) and peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach. The present review provides a detailed examination of past, present and future perspectives of POD mimetic nanozymes for effective oxygen-dependent cancer phototherapeutics.

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“…In addition, bacterial infection and oxidative stress during the wound recovery process could delay wound recovery and seriously affect the quality of life of patients 3 . Although Ag NPs have been were clinically approved antimicrobial agents, some issues related to synthesis methods, potential risks to health and the environmental safety 4–7 . Therefore, it is essential to fabricate a functional wound dressing with antibacterial, anti‐inflammatory or antioxidant properties 8 …”

Section: Introductionmentioning

confidence: 99%

“…3 Although Ag NPs have been were clinically approved antimicrobial agents, some issues related to synthesis methods, potential risks to health and the environmental safety. [4][5][6][7] Therefore, it is essential to fabricate a functional wound dressing with antibacterial, anti-inflammatory or antioxidant properties. 8 Since ancient times, herbs have been used to improve the wound recovery process.…”

Section: Introductionmentioning

confidence: 99%

Electrospun polylactic acid nanofiber membranes containing Capparis spinosa L. extracts for potential wound dressing applications

Zhu

Zhang

Wang

et al. 2021

J of Applied Polymer Sci

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Capparis spinosa L. (CSL) is a medicinal plant with high antibacterial activity against a variety of pathogens and antioxidation properties. In this paper, for the first time, nanofiber membranes of polylactic acid (PLA) containing 0, 4, 7,and 10 wt% CSL ethyl acetate extract were fabricated by electrospinning. Scanning electron microscopy showed that the fiber diameter decreased after adding CSL to the PLA nanofibers. Fourier transform infrared spectroscopy confirmed that CSL was successfully incorporated in the matrix. The water contact angle test proved that the addition of CSL improved the hydrophilic properties of the material. Moreover, the addition of CSL improved the oxidation resistance of the composite fiber membrane. A burst drug release from the composite nanofibers occurred within the first 12 hr, followed by slow release over a prolonged period of time. As the concentration of CSL increased, the inhibition ability of nanofibers against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) gradually increased. In summary, due to their good mechanical, antioxidant, and antibacterial properties, CSL/PLA nanofiber membranes may possess potential applications as wound dressing materials.

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Photosensitized reactive chlorine species-mediated therapeutic destruction of drug-resistant bacteria using plasmonic core–shell Ag@AgCl nanocubes as an external nanomedicine

Abstract: Due to the rapid growth of drug-resistant bacterial infections, there is an urgent need to develop innovative antimicrobial strategies to conquer the bacterial antibiotic resistance problems.

Cited by 39 publications

References 52 publications

Recent Advances of Polyaniline-Based Biomaterials for Phototherapeutic Treatments of Tumors and Bacterial Infections

Recent Advances of Polyaniline-Based Biomaterials for Phototherapeutic Treatments of Tumors and Bacterial Infections

Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives

Electrospun polylactic acid nanofiber membranes containing Capparis spinosa L. extracts for potential wound dressing applications

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