Photosensitizer Nanodot Eliciting Immunogenicity for Photo‐Immunologic Therapy of Postoperative Methicillin‐Resistant Staphylococcus aureus Infection and Secondary Recurrence

Abstract

Figure 10. Schematic image illustrating the promising application of AgB NDs, showing great clinical application prospects for the management of postoperative infection.

Nanosystems for Immune Regulation against Bacterial Infections: A Review

“…Nanosystems are capable of regulating adaptive immunity to fight against bacterial infections. Inspired by the successful application of immunogenic cell death (ICD) in cancer immunotherapy, Tang et al prepared BSA-stabilized Ag 2 S nanodots (AgB NDs) for eliciting immunogenicity (Figure a) . The AgB NDs possessed photothermal and photodynamic effects and were capable of the controlled release of Ag + under NIR irradiation, effectively inhibiting the growth of MRSA.…”

“…(e) Levels of memory B (CD19+/CD38+/CD45+) cells in the blood. Reproduced with permission from ref . Copyright 2022 Wiley-VCH.…”

“…Inspired by the successful application of immunogenic cell death (ICD) in cancer immunotherapy, Tang et al prepared BSA-stabilized Ag 2 S nanodots (AgB NDs) for eliciting immunogenicity (Figure 5a). 58 The AgB NDs possessed photothermal and photodynamic effects and were capable of the controlled release of Ag + under NIR irradiation, effectively inhibiting the growth of MRSA. Moreover, it was found that the ICD of MRSA induced by the combined treatment of AgB NDs and light irradiation could promote the maturation of DCs (Figure 5b,c), regulate the polarization of macrophages, activate T cells (Figure 5d), and induce long-term B-cell-based immunological memory against reinvading MRSA (Figure 5e), possibly attributed to the release of microorganism-associated antigen molecular patterns (MAMPs) and damage-associated molecular patterns (DAMPs) from bacteria and the cells surrounding infected tissue, respectively.…”

Special Issue: Multifunctional Coatings in Orthopedic Implants

“…Enhancing the body's immunity and maintaining an appropriate level of local immune response is a more recommendable way to fight bacteria than through drug molecules, as it creates a long-term, broad-spectrum defense and prevents the development of bacterial resistance [14,15]. Thus, the immunomodulatory function of implant coatings is also an effective strategy against bacteria.…”

Photogenerated Reactive Oxygen Species and Hyperthermia by Cu3SnS4 Nanoflakes for Advanced Photocatalytic and Photothermal Antibacterial Therapy

“…The higher and extended optional absorption of Cu 3 SnS 4 in the visible region (occupies 44% of the solar spectrum) thus makes it a desired photocatalyst for visible (Vis) light activatable antibacterial applications. More importantly, the plasmonic Cu 3 SnS 4 exhibits strong NIR absorption and high quantum e ciency, which could be converted to thermal energy and induce NIR based photothermal sterilization [18][19][20] . Notably, unlike the narrow bandgap metal sul des such as CdS, PbS, ZnInS 4 , AgGaS 2 and ZnCdS, which suffer from drawbacks of elemental toxicity (Cd and Pb) and higher costs (In and Ga).…”