Phototherapeutic functionality of biocompatible graphene oxide/dendrimer hybrids

Siriviriyanun, Ampornphan; Imae, Toyoko; Calderó, Gabriela; Solans, Conxita

doi:10.1016/j.colsurfb.2014.06.010

Cited by 24 publications

(12 citation statements)

References 23 publications

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“…The drastic size variation between F-PEG and F-PEG@GO suggests the groups. 26 The appearance of oxygen-containing functional groups confirmed the preparation of GO. Meanwhile, F-PEG@ GO composite had characteristic IR bands of both F-PEG and GO; CH 2 stretching (2880 cm −1 ) and C−F stretching (1110 cm −1 ) from F-PEG and carbonyl CO (1730 cm −1 ) from GO were noticeably observed in the composite, indicating the coexistence of F-PEG and GO in F-PEG@GO.…”

Section: ■ Results and Discussionmentioning

confidence: 78%

Nitric Oxide Gas Delivery by Fluorinated Poly(Ethylene Glycol)@Graphene Oxide Carrier toward Pharmacotherapeutics

Workie

Sabrina

Imae

et al. 2019

ACS Biomater. Sci. Eng.

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In view of preparing effective nitric oxide gas carriers, a fluorinated poly(ethylene glycol) (F-PEG) was non-covalently conjugated with acid-treated graphene oxide (GO) to prepare the composite of F-PEG@GO. When the persistence of NO gas doped on GO and F-PEG@GO was investigated for 3 h, the conserved NO gas decreased from 49.00±7.06 to 2.17±1.36 nmol/mg carrier and from 58.51± 6.02 to 4.58±2.22 nmol/mg carrier, respectively. The adsorption of F-PEG on GO and the doping of NO on GO and F-PEG@GO were declarative by the increase of distance between GO sheets, and the NO-doping was also clarified by infrared absorption and X-ray photoelectron spectroscopies. The anti-bacterial effect was higher for NO-conserved F-PEG@GO than for NO-conserved GO and more effective against Staphylococcus aureus than against Escherichia coli. It is evident that the coating of F-PEG on GO is preferable for advancing the loading efficiency, the stability and the biomedical efficacy of NO gas.

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Section: ■ Results and Discussionmentioning

confidence: 78%

Nitric Oxide Gas Delivery by Fluorinated Poly(Ethylene Glycol)@Graphene Oxide Carrier toward Pharmacotherapeutics

Workie

Sabrina

Imae

et al. 2019

ACS Biomater. Sci. Eng.

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“…Figure 2 a shows the UV–Vis spectra of GO and ChrGO. GO exhibited a sharp absorption peak at 230 nm and a shoulder at 300 nm, which is ascribed to the π – π * transition of aromatic C=C bonds and n – π * transition of C=O bonds, respectively [ 25 , 26 ]. After chitosan was grafted to GO, the peak at 230 nm redshifted to 270 nm for ChrGO, and the shoulder at 300 nm obviously disappeared, which was ascribed to the partial restoration of electronic conjugation among the aromatic carbon atoms [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

Microwave-Assisted Chitosan-Functionalized Graphene Oxide as Controlled Intracellular Drug Delivery Nanosystem for Synergistic Antitumour Activity

et al. 2021

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To achieve better antitumour efficacy, it is urgent to improve anticancer drug delivery efficiency in targeting cancer cells. In this work, chitosan-functionalized graphene oxide (ChrGO) nanosheets were fabricated via microwave-assisted reduction, which were employed to the intracellular delivery nanosystem for anticancer drug agent in breast cancer cells. Drug loading and release research indicated that adriamycin can be efficiently loaded on and released from the ChrGO nanosheets. Less drug release during delivery and better biocompatibility of ChrGO/adriamycin significantly improve its safety and therapeutic efficacy in HER2-overexpressing BT-474 cells. Furthermore, ChrGO/adriamycin in combination with trastuzumab exhibited synergistic antitumour activity in BT-474 cells, which demonstrated superior therapeutic efficacy compared with each drug alone. Cells treated with trastuzumab (5 μg/mL) or equivalent ChrGO/adriamycin (5 μg/mL) each elicited 54.5% and 59.5% cell death, respectively, while the combination treatment with trastuzumab and ChrGO/adriamycin resulted in a dramatic 88.5% cell death. The dual-targeted therapy displayed higher apoptosis, indicating superior therapeutic efficacy due to the presence of different mechanisms of action. The combined treatment of ChrGO/adriamycin and trastuzumab in BT-474 cells induced cell cycle arrest and apoptosis, which ultimately led to the death of augmented cancer cells. This work has provided a facile microwave-assisted fabrication of ChrGO as a controlled and targeted intracellular drug delivery nanosystem, which is expected to be a novel promising therapy for treating HER2-overexpressing breast cancer cells.

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“…Third, the fluorophore was used for the measurement can be caused chemotoxicity. Recently (2014), the photocytotoxicity study revealed that hydroxyl-terminated fourth generation poly(amido amine) dendrimer and folic acid under the two-photon excitation at 780 nm, the hybrids can absorb nearinfrared light and generate reactive oxygen species which can oxidize the HeLa cells and cause their death, suggesting the phototherapeutic behavior [30]. Acridine orange is a cell-permeant nucleic acid binding dye that emits green fluorescence when bound to dsDNA and red fluorescence when bound to ssDNA or RNA.…”

Section: Epifluorescence Studiesmentioning

confidence: 99%

Near infrared (NIR) laser mediated surface activation of graphene oxide nanoflakes for efficient antibacterial, antifungal and wound healing treatment

Khan

Abdelhamid²,

2015

Colloids and Surfaces B: Biointerfaces

180

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Phototherapeutic functionality of biocompatible graphene oxide/dendrimer hybrids

Cited by 24 publications

References 23 publications

Nitric Oxide Gas Delivery by Fluorinated Poly(Ethylene Glycol)@Graphene Oxide Carrier toward Pharmacotherapeutics

Nitric Oxide Gas Delivery by Fluorinated Poly(Ethylene Glycol)@Graphene Oxide Carrier toward Pharmacotherapeutics

Microwave-Assisted Chitosan-Functionalized Graphene Oxide as Controlled Intracellular Drug Delivery Nanosystem for Synergistic Antitumour Activity

Near infrared (NIR) laser mediated surface activation of graphene oxide nanoflakes for efficient antibacterial, antifungal and wound healing treatment

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