Photothermal ablation therapy for cancer based on metal nanostructures

Rozanova, Nadejda; Zhang, J. Z.

doi:10.1007/s11426-009-0247-0

Cited by 41 publications

(30 citation statements)

References 65 publications

(139 reference statements)

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“…Two main aspects were considered, ie, the instrument and the cell line. The instrument was similar to others currently being used, 18,25 but with the possibility of using different excitation methods by changing the light exposure pattern from continuous wave light to pulsed light. This system was developed to evaluate the effectiveness of gold nanorods designed to work in the optimal tissue window for light absorbance (808 nm).…”

Section: Discussionmentioning

confidence: 99%

Induction of cell death in a glioblastoma line by hyperthermic therapy based on gold nanorods

Fernández‐Cabada¹,

Pablo²,

Serrano³

et al. 2012

IJN

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Background: Metallic nanorods are promising agents for a wide range of biomedical applications. In this study, we developed an optical hyperthermia method capable of inducing in vitro death of glioblastoma cells. Methods: The procedure used was based on irradiation of gold nanorods with a continuous wave laser. This kind of nanoparticle converts absorbed light into localized heat within a short period of time due to the surface plasmon resonance effect. The effectiveness of the method was determined by measuring changes in cell viability after laser irradiation of glioblastoma cells in the presence of gold nanorods. Results: Laser irradiation in the presence of gold nanorods induced a significant decrease in cell viability, while no decrease in cell viability was observed with laser irradiation or incubation with gold nanorods alone. The mechanism of cell death mediated by gold nanorods during photothermal ablation was analyzed, indicating that treatment compromised the integrity of the cell membrane instead of initiating the process of programmed cell death. Conclusion:The use of gold nanorods in hyperthermal therapies is very effective in eliminating glioblastoma cells, and therefore represents an important area of research for therapeutic development.

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Section: Discussionmentioning

confidence: 99%

Induction of cell death in a glioblastoma line by hyperthermic therapy based on gold nanorods

Fernández‐Cabada¹,

Pablo²,

Serrano³

et al. 2012

IJN

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“…This has several important applications, not least, in the field of medicine wherein there is significant ongoing research on the use of nanoparticles for hyperthermia-based destruction of tumor cells. [3][4][5][6] Thermal therapeutics offers several benefits over conventional approaches for cancer treatment: they are non-invasive, relatively simple to perform, and have the potential of treating embedded tumors in regions where surgery is difficult.…”

Section: Introductionmentioning

confidence: 99%

Curvature induced phase stability of an intensely heated liquid

Sasikumar

Liang

Cahill

et al. 2014

The Journal of Chemical Physics

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We use non-equilibrium molecular dynamics simulations to study the heat transfer around intensely heated solid nanoparticles immersed in a model Lennard-Jones fluid. We focus our studies on the role of the nanoparticle curvature on the liquid phase stability under steady-state heating. For small nanoparticles we observe a stable liquid phase near the nanoparticle surface, which can be at a temperature well above the boiling point. Furthermore, for particles with radius smaller than a critical radius of 2 nm we do not observe formation of vapor even above the critical temperature. Instead, we report the existence of a stable fluid region with a density much larger than that of the vapor phase. We explain the stability in terms of the Laplace pressure associated with the formation of a vapor nanocavity and the associated effect on the Gibbs free energy.

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“…Gold nanoparticles have been a common choice for contrast and therapeutic agents based on their superior optical properties,11–21 biocompatibility, and ease of bioconjugation with biomarkers to create nano-sized contrast agents with molecular specificity 11–14, 19, 22–24. The conventional strategy of designing plasmonic photoacoustic contrast agents is usually to maximize the optical absorption cross-section of nanoparticles by manipulating their size and shape, and to choose the peak position and the relative amplitude of the absorption and scattering cross-sections 25–27.…”

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confidence: 99%

Silica-Coated Gold Nanorods as Photoacoustic Signal Nanoamplifiers

et al. 2011

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Photoacoustic signal generation by metal nanoparticles relies on the efficient conversion of light to heat, its transfer to the environment and the production of pressure transients. In this study we demonstrate that a dielectric shell has a strong influence on the amplitude of the generated photoacoustic signal, and that silica coated gold nanorods of the same optical density are capable of producing about 3-fold higher photoacoustic signals than nanorods without silica coating. Spectrophotometry measurements and finite difference time domain (FDTD) analysis of gold nanorods before and after silica coating showed only an insignificant change of the extinction and absorption cross-sections, hence indicating that the enhancement is not attributable to changes in absorption cross-section resulting from the silica coating. Several factors including the silica thickness, the gold/silica interface, and the surrounding solvent were varied to investigate their effect on the photoacoustic signal produced from silica-coated gold nanorods. The results suggest that the enhancement is caused by the reduction of the gold interfacial thermal resistance with the solvent due to the silica coating. The strong contrast enhancement in photoacoustic imaging, demonstrated using phantoms with silica-coated nanorods, shows that these hybrid particles acting as "photoacoustic nano-amplifiers" are high efficiency contrast agents for photoacoustic imaging or photoacoustic image-guided therapy. KeywordsPhotoacoustic imaging; silica coated-gold nanorods; photoacoustic nano-amplifiers; medical and biological imaging; contrast agents Photoacoustic imaging is a non-ionizing and noninvasive imaging modality that combines the advantages of both optical and acoustic imaging. [1][2][3][4] In photoacoustic imaging, the intensity modulated electromagnetic radiation, e.g. a beam of pulsed laser light, is directed at the imaging target. The light is absorbed and converted to an outgoing thermoacoustic wave that can be detected by an ultrasound transducer and used to reconstruct images.5 -8 Since light is only used for heating and not for imaging, and acoustic waves are less scattered in optically turbid materials such as tissue, photoacoustic imaging can reach far deeper into turbid materials than purely optical imaging techniques.8 -9 The contrast in photoacoustic * To whom correspondence should be addressed. Telephone: (512) 471-1733. Fax: (512) imaging depends on the optical-to-acoustic conversion (optoacoustic) efficiency, i.e., how many incident photons can be absorbed and converted to heat, and how fast the generated heat can diffuse out from the target during thermoelastic expansion and wave generation. When a uniformly absorbing target is irradiated by pulsed light, the amplitude of the generated photoacoustic signal is proportional to the optical absorption and the thermalacoustic properties of the absorbing medium. In contrast, in a heterogeneous medium such as a weakly absorbing solvent containing plasmonic nanoparticles, the amp...

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Photothermal ablation therapy for cancer based on metal nanostructures

Cited by 41 publications

References 65 publications

Induction of cell death in a glioblastoma line by hyperthermic therapy based on gold nanorods

Induction of cell death in a glioblastoma line by hyperthermic therapy based on gold nanorods

Curvature induced phase stability of an intensely heated liquid

Silica-Coated Gold Nanorods as Photoacoustic Signal Nanoamplifiers

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