Photothermal deflectometry enhanced by total internal reflection enables non-invasive glucose monitoring in human epidermis

Pleitez, Miguel A.; Hertzberg, Otto; Bauer, Alexander; Seeger, Markus; Lieblein, Tobias; Lilienfeld-Toal, H. v.; Mäntele, Werner

doi:10.1039/c4an01185f

Cited by 41 publications

(25 citation statements)

References 20 publications

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“…In clinical applications, mid-infrared microspectroscopy has shown potential for fast quantitative cancer diagnosis based on histological samples, without major disturbance to the routine pathology workflow (Baker et al, 2014). Additionally, the sensitivity and specificity of mid-infrared spectroscopy have proven adequate for non-invasive label-free glucose monitoring in human epidermis when combined with excitation by a quantum cascade laser and optoacoustic or photothermal detection (Pleitez et al, 2013(Pleitez et al, , 2015Sim et al, 2018). However, because of the strong absorption of mid-infrared radiation by water, applying mid-infrared microscopy to live-cell or tissue imaging requires confining cells within cuvettes about 10 mm thick in order to reduce the column of water.…”

Section: Optical Microscopymentioning

confidence: 99%

Emerging Technologies to Image Tissue Metabolism

et al. 2019

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Due to the implication of altered metabolism in a large spectrum of tissue function and disease, assessment of metabolic processes becomes essential in managing health. In this regard, imaging can play a critical role in allowing observation of biochemical and physiological processes. Nuclear imaging methods, in particular positron emission tomography, have been widely employed for imaging metabolism but are mainly limited by the use of ionizing radiation and the sensing of only one parameter at each scanning session. Observations in healthy individuals or longitudinal studies of disease could markedly benefit from non-ionizing, multi-parameter imaging methods. We therefore focus this review on progress with the non-ionizing radiation methods of MRI, hyperpolarized magnetic resonance and magnetic resonance spectroscopy, chemical exchange saturation transfer, and emerging optoacoustic (photoacoustic) imaging. We also briefly discuss the role of nuclear and optical imaging methods for research and clinical protocols.

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Section: Optical Microscopymentioning

confidence: 99%

Emerging Technologies to Image Tissue Metabolism

et al. 2019

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“…This method presents some advantages over others due to its capability to measure concentration in situ without interrupting the process as well as the simple post processing work thereafter. As such, the method has been used since in the early 1990s up until recently (Maier et al 1994, Chance et al 1995, Liu et al 1996, Tuchin et al 1997, Wang 2000, Vargas et al 2001, Yao et al 2002, Bashkatov et al 2003, Zhang et al 2013a,b, Trichet et al 2014, Ullah et al 2014, Pleitez et al 2015.…”

Section: Refractive Index Methodsmentioning

confidence: 99%

Glucose diffusion in tissue engineering membranes and scaffolds

Suhaimi

Das

2016

Reviews in Chemical Engineering

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Tissue engineering has evolved into an exciting area of research due to its potential in regenerative medicine. The shortage of organ donors as well as incompatibility between patient and donor pose an alarming concern. This has resulted in an interest in regenerative therapy where the importance of understanding the transport properties of critical nutrients such as glucose in numerous tissue engineering membranes and scaffolds is crucial. This is due to its dependency on successful tissue growth as a measure of potential cure for health issues that cannot be healed using traditional medical treatments. In this regard, the diffusion of glucose in membranes and scaffolds that act as templates to support cell growth must be well grasped. Keeping this in mind, this review paper aims to discuss the glucose diffusivity of these materials. The paper reviews four interconnected issues, namely, (i) the glucose diffusion in tissue engineering materials, (ii) porosity and tortuosity of these materials, (iii) the relationship between microstructure of the material and diffusion, and (iv) estimation of glucose diffusivities in liquids, which determine the effective diffusivities in the porous membranes or scaffolds. It is anticipated that the review paper would help improve the understanding of the transport properties of glucose in membranes and scaffolds used in tissue engineering applications.

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“…Other non-invasive approaches include polarimetry [20] Raman spectroscopy [21], photoacoustics [22], optical coherence tomography [23], and photothermal deflectometer enhanced by total internal reflection [24].…”

Section: Glucose Monitoring Methods: Invasive and Non-invasivementioning

confidence: 99%

Role of Peroxidase in Clinical Assays: A Short Review

Shivakumar¹,

Bg²,

Mr³

2017

J Clin Nutr Diet

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Development of sensitive enzymatic methods for hydrogen peroxide is key for the quantification of several bioconstituents such as glucose, triglycerides, creatinine, and uric acid and so on. Hydrogen peroxide released by the oxidase enzymes are quantified by peroxidase enzyme involving spectrophotometry, fluorimetry, chemiluminisence, potentiometric sensing, amperometric, coulometric and such others. Authors in this line, present a short review on the assay of peroxidase. The entire review is divided into three different sections; first the importance of peroxidase clinically, secondly peroxidase chemistry with hydrogen peroxide and finally its role in the assay of bioconstituents.Keywords: Peroxidase; Clinical importance; Oxidase enzymes; Glucose assay; Nano sensors Role of Peroxidase in ClinicalAssays: A Short Review Peroxidase: A Clinically Important EnzymePeroxidases are widely distributed in nature especially in animal and plant cells. Peroxidases comprise of three major categories; plant peroxidases, animal peroxidases and catalases. These enzymes utilize hydrogen peroxide to catalyze the oxidation of variety of organic and inorganic compounds.

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Photothermal deflectometry enhanced by total internal reflection enables non-invasive glucose monitoring in human epidermis

Cited by 41 publications

References 20 publications

Emerging Technologies to Image Tissue Metabolism

Emerging Technologies to Image Tissue Metabolism

Glucose diffusion in tissue engineering membranes and scaffolds

Role of Peroxidase in Clinical Assays: A Short Review

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