Photothermal responsive cell-laden PNIPAM self-rolling hydrogel containing dopamine enhanced MWCNTs for peripheral nerve regeneration

Li, Guicai; Zhang, Liling; Han, Qi; Zheng, Tiantian; Wu, Linliang; Guan, Wenchao; Sun, Shaolan; Yang, Yumin

doi:10.1016/j.compositesb.2023.110551

Cited by 14 publications

(3 citation statements)

References 52 publications

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“…Mechanical devices play an important role in both industrial production and people’s daily lives. Among them, mechanical hand claws have significant applications in tasks such as parts assembly and cargo grasping. − Given their structure, the design of micro hand claw robots also requires suitable materials to achieve flexible grasping and releasing within the operating environment. , Hydrogels have been frequently utilized in recent research on flexible microrobotics due to their good biophilicity and capability to operate effectively underwater. − …”

Section: Introductionmentioning

confidence: 99%

A Powerful Dual-Responsive Hand Claw Structured by a Photothermal Double Layer Based on Poly(N-isopropylacrylamide) and Carbon Nanotubes

Liu,

Qiao,

Teng

et al. 2024

ACS Appl. Polym. Mater.

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Drawing upon the strong application potential of mechanical hand claws, we have designed a dual-responsive hand claw structured by a photothermal double layer based on poly(N-isopropylacrylamide) and carbon nanotubes. By harnessing the photothermal conversion effect of carbon nanotubes on the hydrogel surface, the hydrogel reversibly absorbs and drains water, thus realizing the basic function of the hand claw. In addition, the integration of the magnetic material with the flexible robot, with the help of magnetic field actuation, effectively improves the mobility and flexibility of the hand claw and makes up for some of the shortcomings of traditional flexible robots. The enhancement of performance through opticalmagnetic coupling will provide some valuable insights for the research of underwater microrobots.

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Section: Introductionmentioning

confidence: 99%

A Powerful Dual-Responsive Hand Claw Structured by a Photothermal Double Layer Based on Poly(N-isopropylacrylamide) and Carbon Nanotubes

Liu,

Qiao,

Teng

et al. 2024

ACS Appl. Polym. Mater.

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“…Among these, poly(N-isopropylacrylamide)based hydrogels stand out as a class of smart hydrogels with thermo-responsive behavior. 28 Incorporating recognition elements in the hydrogel structure allows for responsive reactions with specific chemical substances. Consequently, these interactions trigger changes in the solubility or charge state of the hydrogel.…”

Section: Introductionmentioning

confidence: 99%

Lysozyme-sensitive plasmonic hydrogel nanocomposite for colorimetric dry-eye inflammation biosensing

Ziai,

Rinoldi,

Petronella

et al. 2024

Nanoscale

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“…Among them, multiwalled carbon nanotubes (MWCNTs) show a strong absorption capacity of near-infrared light. It can kill tumor cells under photothermal treatment without cytotoxicity; thus, MWCNTs are usually used as the photothermal responsive nanomaterials for preparing photothermal sensitive hydrogel . Based on the above-mentioned, combining photothermal responsiveness with injectable drug-loaded hydrogel microspheres will have potential promise for enhancing the repair effect of SCI.…”

Section: Introductionmentioning

confidence: 99%

Injectable Near-Infrared Photothermal Responsive Drug-Loaded Multiwalled Carbon Nanotube Hydrogels for Spinal Cord Injury Repair

Sun,

Liu,

Guan

et al. 2023

ACS Appl. Nano Mater.

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Spinal cord injury (SCI) has a high disability rate and poor treatment efficacy and severely affects the health and daily life of patients. Improving the local microenvironment after SCI is crucial for restoring the normal physiological function of the spinal cord. In this study, the injectable near-infrared (NIR) photothermal responsive drug-loaded multiwalled carbon nanotubes (DMWCNTs) containing hydrogel microspheres were prepared by microfluidic technology for SCI treatment. Specifically, paclitaxel (PTX) and vascular endothelial growth factor (VEGF) were loaded into dopamine-modified DMWCNTs, which were then further compounded into gellan gum (GG) by using microfluidic technology to obtain [PTX/VEGF]@DMWCNTs/GG microspheres. The physicochemical properties of the microspheres were characterized using various methods, including transmission electron microscopy (TEM), energy-dispersive X-ray (EDX) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, optical microscopy, and scanning electron microscopy (SEM). Results showed that microspheres with good injectability and controllable drug release were successfully prepared by using microfluidic technology. The presence of MWCNTs endowed the microspheres with photothermal responsiveness, which led to more drug release under NIR irradiation. The cytotoxicity test results showed that the microspheres had no obvious cytotoxicity and the drug-loaded MWCNTs containing hydrogel microspheres could promote the differentiation of neural stem cells (NSCs). Immunofluorescence results in rats with hemisectioned SCI showed that the microspheres promoted the differentiation of NSCs and the growth of neurons and inhibited the formation of astrocytes and glial scars at the lesion site. In conclusion, the injectable near-infrared photothermal responsive drug-loaded multiwalled carbon nanotube hydrogel microspheres prepared in this study exhibit a promoting effect on SCI repair and provide a strategy for developing transplantation materials for SCI treatment.

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Photothermal responsive cell-laden PNIPAM self-rolling hydrogel containing dopamine enhanced MWCNTs for peripheral nerve regeneration

Cited by 14 publications

References 52 publications

A Powerful Dual-Responsive Hand Claw Structured by a Photothermal Double Layer Based on Poly(N-isopropylacrylamide) and Carbon Nanotubes

A Powerful Dual-Responsive Hand Claw Structured by a Photothermal Double Layer Based on Poly(N-isopropylacrylamide) and Carbon Nanotubes

Lysozyme-sensitive plasmonic hydrogel nanocomposite for colorimetric dry-eye inflammation biosensing

Injectable Near-Infrared Photothermal Responsive Drug-Loaded Multiwalled Carbon Nanotube Hydrogels for Spinal Cord Injury Repair

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