Photothermal-triggered release of alkyl radicals and cascade generation of hydroxyl radicals via a versatile hybrid nanocatalyst for hypoxia-irrelevant synergistic antibiofilm therapy

Li, Huan; Yang, Ke; Hai, Luo; Wang, Zefeng; Luo, Yuze; He, Lidan; Yi, Wenhua; Li, Junqin; Xu, Caiyun; Deng, Le; He, Dinggeng

doi:10.1016/j.cej.2022.140903

Cited by 25 publications

(12 citation statements)

References 48 publications

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“…Since silica-cored Au nanoshells served as the first photothermal nanomaterials for clinical use, more and more inorganic agents with strong absorption in the NIR region, high chemical stability, adjustable water solubility, and minimal cytotoxicity have entered clinical trials. , Clinical trials have also been underway for small organic molecules due to their good biodegradability, good repeatability, and simple preparation. , Nevertheless, the major challenges for the clinical implementation of photothermal nanomaterials are the complex metabolism and excretion behaviors . The representative works on PTT with diverse photothermal nanomaterials in recent years − are summarized in Table .…”

Section: Applicationsmentioning

confidence: 99%

Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

et al. 2023

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All forms of energy follow the law of conservation of energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means of converting light into thermal energy has been of enduring appeal to researchers and the public. With the continuous development of advanced nanotechnologies, a variety of photothermal nanomaterials have been endowed with excellent light harvesting and photothermal conversion capabilities for exploring fascinating and prospective applications. Herein we review the latest progresses on photothermal nanomaterials, with a focus on their underlying mechanisms as powerful light-to-heat converters. We present an extensive catalogue of nanostructured photothermal materials, including metallic/semiconductor structures, carbon materials, organic polymers, and twodimensional materials. The proper material selection and rational structural design for improving the photothermal performance are then discussed. We also provide a representative overview of the latest techniques for probing photothermally generated heat at the nanoscale. We finally review the recent significant developments of photothermal applications and give a brief outlook on the current challenges and future directions of photothermal nanomaterials.

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Section: Applicationsmentioning

confidence: 99%

Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

et al. 2023

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“…Similarly, Li et al loaded Gox and a thermally unstable azo initiator, water-soluble 2,2′-azobis[2-(2-imidazolin-2yl)propane] dihydrochloride (AIBI) onto flower-like MnO 2 to construct a dual radical nanogenerator (MnO 2 /Gox/AIBI) for reducing GSH overexpression at the infection site to enhance the efficacy of CDT. [44] On the one hand, MnO 2 can deplete overexpressed GSH at the infection site; on the other hand, MnO 2 /Gox/AIBI can use glucose to induce a cascade catalytic reaction to generate •OH for bacterial elimination because Gox can catalyse glucose to produce H 2 O 2 and gluconic acid, which exhibits strong application prospects in diabetic wound infection. Another example was presented by Li et al In their work, a multifunctional chemodynamic agent (MoS 2 /CuO 2 ) was constructed by decorating ultrasmall CuO 2 nanodots onto a hydrangea-like MoS 2 nanocarrier using a covalent Cu─S bond.…”

Section:  Inhibition Of Gsh Overexpressionmentioning

confidence: 99%

“…This synergistic effect contributes to the effectiveness of CDT in eradicating bacterial infections. [44,67] Su et al developed a nanobionics catalyst with a bilayer structure, known as MACG, for combating peri-implant biofilm infections (Figure 7B). [77] The preparation involved loading an activatable photothermal agent (ABTS) into the MOF of MIL-100 and anchoring Cu 2+ in the pore channels of MIL-100.…”

Section:  Cdt-immunotherapymentioning

confidence: 99%

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Recent design strategies for boosting chemodynamic therapy of bacterial infections

Zhang,

Guo,

Liu

et al. 2023

Exploration

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The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue to persist. Currently, antibiotic therapy remains the primary approach for tackling bacterial infections. However, the escalating rates of drug resistance coupled with the lag in the development of novel drugs have led to diminishing effectiveness of conventional treatments. Therefore, the development of nonantibiotic‐dependent therapeutic strategies has become imperative to impede the rise of bacterial resistance. The emergence of chemodynamic therapy (CDT) has opened up a new possibility due to the CDT can convert H2O2 into •OH via Fenton/Fenton‐like reaction for drug‐resistant bacterial treatment. However, the efficacy of CDT is limited by a variety of practical factors. To overcome this limitation, the sterilization efficiency of CDT can be enhanced by introducing the therapeutics with inherent antimicrobial capability. In addition, researchers have explored CDT‐based combined therapies to augment its antimicrobial effects and mitigate its potential toxic side effects toward normal tissues. This review examines the research progress of CDT in the antimicrobial field, explores various strategies to enhance CDT efficacy and presents the synergistic effects of CDT in combination with other modalities. And last, the current challenges faced by CDT and the future research directions are discussed.

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“…In addition, • OH, the most destructive ROS, can oxidise and destroy bacterial cells. 24,25 Thus, Fe 3 O 4 NPs can provide not only additional O 2 but also exhibit direct antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

An ultrasound-controllable ROS-responsive nanoplatform for O₂ and NO generation to enhance sonodynamic therapy against multidrug-resistant bacterial infections

Zhang,

Zhang

et al. 2023

Nanoscale

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Photothermal-triggered release of alkyl radicals and cascade generation of hydroxyl radicals via a versatile hybrid nanocatalyst for hypoxia-irrelevant synergistic antibiofilm therapy

Cited by 25 publications

References 48 publications

Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Recent design strategies for boosting chemodynamic therapy of bacterial infections

An ultrasound-controllable ROS-responsive nanoplatform for O₂ and NO generation to enhance sonodynamic therapy against multidrug-resistant bacterial infections

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Photothermal-triggered release of alkyl radicals and cascade generation of hydroxyl radicals via a versatile hybrid nanocatalyst for hypoxia-irrelevant synergistic antibiofilm therapy

Cited by 25 publications

References 48 publications

Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Recent design strategies for boosting chemodynamic therapy of bacterial infections

An ultrasound-controllable ROS-responsive nanoplatform for O2 and NO generation to enhance sonodynamic therapy against multidrug-resistant bacterial infections

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Product

Resources

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An ultrasound-controllable ROS-responsive nanoplatform for O₂ and NO generation to enhance sonodynamic therapy against multidrug-resistant bacterial infections