Photothrombosis of Corneal Neovascularization by Intravenous Rose Bengal and Argon Laser Irradiation

Reactivity towards singlet oxygen of propofol inside liposomes and neuronal cells

“…At the concentration used to produce 1 O 2 , no toxic effect was observed (data not shown). We chose the irradiation of Rose Bengal (RB) as a mean of generating 1 O 2 in cells since this reaction system is easily controlled, ensuring a constant production of 1 O 2 , and because the irradiation of RB is known to induce a cytotoxic effect due to 1 O 2 production [36,37].…”

Photodynamic Effect of a New Photosensitizer ATX-S10 on Corneal Neovascularization

“…In the field of ophthalmology as well, the occlusive effect of PDT on ocular vessels has been obtained through thrombus formation (Royster et al, 1988 ;Kliman et al, 1994b ;Schmidt-Erfurth et al, 1994 ;Peyman et al, 1997). This finding led to the attempt to apply PDT to the treatment of ocular diseases associated with neovascularization in the cornea (Huang et al, 1989 ;Corrent et al, 1989 ;Pallikaris et al, 1993 ;Tsilimbaris et al, 1994 ;Schmidt-Erfurth et al, 1995 ;Obana et al, 1996 ;Soliman et al, 1997), iris (Packer et al, 1984 ;Miller et al, 1991), subretina (Thomas and Langhofer, * Correspondence and requests for reprints should be addressed to: Yuko Gohto, Department of Ophthalmology, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.…”

“…Several first-generation photosensitizers including rose bengal (Royster et al, 1988 ;Huang et al, 1989 ;Corrent et al, 1989) and dihematoporphyrin ether\ ester (Packer et al, 1984, Obana et al, 1996 were developed, but proved to be inappropriate for the clinical use because of either prolonged cutaneous photosensitivity resulting from slow-rate excretion or low photodynamic activity. Recently, Sakata et al synthesized a water-soluble photosensitizer ATX-S10 with a longer absorption wavelength, greater absorption efficiency, lower skin photosensitivity, stronger photooxygenation activities and a higher value of LD &!…”

Treatment Parameters for Selective Occlusion of Experimental Corneal Neovascularization by Photodynamic Therapy using a Water Soluble Photosensitizer, ATX-S10(Na)

“…Such lengthy hospitalization is undesirable. Rose bengal also has been used with PDT to occlude CoNV (Huang et al, 1988), but it is not approved for human treatment.…”