PHTF2 regulates lipids metabolism in gastric cancer

Chi, Yuling; Wang, Haiyan; Wang, Fengsong; Ding, Mingcui

doi:10.18632/aging.102995

Cited by 20 publications

(14 citation statements)

References 26 publications

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“…There were several literatures using the same dataset in this study ( Chen et al, 2020 ; Chi et al, 2020 ; Li Z. et al, 2020 ; Tian et al, 2020 ; Wang F. et al, 2020 ; Wu et al, 2020 ). However, most of them selected multiple genes for GC by some routine methods and did not concentrate on one gene/biomarker.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Cyclin-Dependent Kinase 1 as an Independent Prognostic Factor for Gastric Cancer Based on Statistical Methods

Zhang

Zou

et al. 2020

Front. Cell Dev. Biol.

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ObjectiveThe aim of this study was to investigate the expression of cyclin-dependent kinase 1 (CDK1) in gastric cancer (GC), evaluate its relationship with the clinicopathological features and prognosis of GC, and analyze the advantage of CDK1 as a potential independent prognostic factor for GC.MethodsThe Cancer Genome Atlas (TCGA) data and corresponding clinical features of GC were collected. First, the aim gene was selected by combining five topological analysis methods, where the gene expression in paracancerous and GC tissues was analyzed by Limma package and Wilcox test. Second, the correlation between gene expression and clinical features was analyzed by logistic regression. Finally, the survival analysis was carried out by using the Kaplan–Meier. The gene prognostic value was evaluated by univariate and multivariate Cox analyses, and the gene potential biological function was explored by gene set enrichment analysis (GSEA).ResultsCDK1 was selected as one of the most important genes associated with GC. The expression level of CDK1 in GC tissues was significantly higher than that in paracancerous tissues, which was significantly correlated with pathological stage and grade. The survival rate of the CDK1 high expression group was significantly lower than that of the low expression group. CDK1 expression was significantly correlated with overall survival (OS). CDK1 expression was mainly involved in prostate cancer, small cell lung cancer, and GC and was enriched in the WNT signaling pathway and T cell receptor signaling pathway.ConclusionCDK1 may serve as an independent prognostic factor for GC. It is also expected to be a new target for molecular targeted therapy of GC.

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Section: Discussionmentioning

confidence: 99%

Analysis of Cyclin-Dependent Kinase 1 as an Independent Prognostic Factor for Gastric Cancer Based on Statistical Methods

Zhang

Zou

et al. 2020

Front. Cell Dev. Biol.

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“…As a worldwide malignant tumor, GC is reported to have heterogeneous characteristics in the digestive system 39 . Although many novel diagnostic techniques and surgical skills have been developed in recent years, they are not always sufficient.…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis identifies oxidative stress genes associated with progression and prognosis in gastric cancer

Wang

Wen

et al. 2021

Sci Rep

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Oxidative stress (OS) reactions are reported to be associated with oncogenesis and tumor progression. However, little is known about the potential diagnostic value of OS in gastric cancer (GC). This study identified hub OS genes associated with the prognosis and progression of GC and illustrated the underlying mechanisms. The transcriptome data and corresponding GC clinical information were collected from The Cancer Genome Atlas (TCGA) database. Aberrantly expressed OS genes between tumors and adjacent normal tissues were screened, and 11 prognosis-associated genes were identified with a series of bioinformatic analyses and used to construct a prognostic model. These genes were validated in the Gene Expression Omnibus (GEO) database. Furthermore, weighted gene co-expression network analysis (WGCNA) was subsequently conducted to identify the most significant hub genes for the prediction of GC progression. Analysis revealed that a good prognostic model was constructed with a better diagnostic accuracy than other clinicopathological characteristics in both TCGA and GEO cohorts. The model was also significantly associated with the overall survival of patients with GC. Meanwhile, a nomogram based on the risk score was established, which displayed a favorable discriminating ability for GC. In the WGCNA analysis, 13 progression-associated hub OS genes were identified that were also significantly associated with the progression of GC. Furthermore, functional and gene ontology (GO) analyses were performed to reveal potential pathways enriched with these genes. These results provide novel insights into the potential applications of OS-associated genes in patients with GC.

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“…metabolism-related genes are reported to affect the prognosis of gastric cancer 30 . Furthermore, PHTF2 is found to regulates lipids metabolism in gastric cancer 31 . But most of these studies concentrate on protein-coding genes, the metabolism-related non-coding RNA remains largely unexplored.…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncRNA

2021

Sci Rep

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Increasing evidence has demonstrated that lncRNAs are critical regulators in diverse biological processes, but the function of lncRNA in metabolic regulation remains largely unexplored. In this study, we evaluated the association between lncRNA and metabolic pathways and identified metabolism-related lncRNAs. Gastric cancer can be mainly subdivided into 2 clusters based on these metabolism-related lncRNA regulators. Comparative analysis shows that these subtypes are found to be highly consistent with previously identified subtypes based on other omics data. Functional enrichment analysis shows that they are enriched in distinct biological processes. Mutation analysis shows that ABCA13 is a protective factor in subtype C1 but a risk factor in C2. Analysis of chemotherapeutic and immunotherapeutic sensitivity shows that these subtypes tend to display distinct sensitivity to the same chemical drugs. In conclusion, these findings demonstrated the significance of lncRNA in metabolic regulation. These metabolism-related lncRNA regulators can improve our understanding of the underlying mechanism of lncRNAs and advance the research of immunotherapies in the clinical management of gastric cancer.

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PHTF2 regulates lipids metabolism in gastric cancer

Cited by 20 publications

References 26 publications

Analysis of Cyclin-Dependent Kinase 1 as an Independent Prognostic Factor for Gastric Cancer Based on Statistical Methods

Analysis of Cyclin-Dependent Kinase 1 as an Independent Prognostic Factor for Gastric Cancer Based on Statistical Methods

Integrated analysis identifies oxidative stress genes associated with progression and prognosis in gastric cancer

Molecular characterization of metabolic subtypes of gastric cancer based on metabolism-related lncRNA

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